PROCEEDINGS FROM THE INTERNATIONAL SOCIETY OF BLOOD TRANSFUSION WORKING PARTY ON IMMUNOHAEMATOLOGY, WORKSHOP ON THE CLINICAL SIGNIFICANCE OF RED BLOOD CELL ALLOANTIBODIES, SEPTEMBER 9, 2016, DUBAI: Clinical significance of antibodies to antigens in the ABO, MNS, P1PK, Rh, Lutheran, Kell, Lewis, Duffy, Kidd, Diego, Yt, and Xg blood group systems

Thornton, N.M.; Grimsley, S.P.

doi:10.21307/immunohematology-2020-021

Abstract

This report is part of a series reporting the proceedings from the International Society of Blood Transfusion (ISBT) Working Party on Immunohaematology Workshop on the Clinical Significance of Red Blood Cell Alloantibodies. The aim of the workshop was to review information regarding the clinical significance of alloantibodies to red blood cell antigens recognized by the ISBT. The first 12 systems will be covered in this report. It is understandable that many of the most clinically important antibodies are directed toward antigens found in the blood group systems discovered earlier in history. The ABO system was the first to be discovered and remains the most clinically important regarding transfusion.

References

International Society of Blood Transfusion. Working Party for Red Cell Immunogenetics and Blood Group Terminology. Available from http://www.isbtweb.org/fileadmin/user_upload/Red_Cell_Terminology_and_Immunogenetics/Table_of_blood_group_antigens_within_systems_v8_180620.pdf. Accessed 23 June 2019.
Search in Google Scholar Back to article
Daniels G. Human blood groups. 3rd ed. Chichester, UK: Blackwell Science, 2013.
Search in Google Scholar Back to article
Reid ME, Lomas-Francis C, Olsson ML. The blood group antigen factsbook. 3rd ed. Waltham, MA: Academic Press, 2012.
Search in Google Scholar Back to article
Milkins C, Berryman J, Cantwell C, et al. Guidelines for pretransfusion compatibility procedures in blood transfusion laboratories: BCSH guidelines. Transfus Med 2013;23:3–35.
Search in Google Scholar Back to article
Poole J, Daniels G. Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 2007;21:58–71.
Search in Google Scholar Back to article
Storry JR, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology 2009;25:48–59.
Search in Google Scholar Back to article
Hellberg Å, Westman JS, Thuresson B, Olsson ML. P1PK: the blood group system that changed its name and expanded. Immunohematology 2013;29:23–33.
Search in Google Scholar Back to article
Duk M, Westerlind U, Norberg T, Pazynina G, Bovin N, Lisowskal E. Specificity of human anti-NOR antibodies, a distinct species of “natural” anti-a-galactosyl antibodies. Glycobiology 2003;13:279–84.
Search in Google Scholar Back to article
Kollamparambil TG, Jani BR, Aldouri M, Soe A, Ducker DA. Anti-CW alloimmunization presenting as hydrops fetalis. Acta Paediatr 2005;94:499–507.
Search in Google Scholar Back to article
Hustinx H, Lejon-Crottet S, Henny C, et al. LUIT: a novel high incidence antigen in the Lutheran blood group system (abstract). Vox Sang 2014;107:172.
Search in Google Scholar Back to article
Scharberg EA, Wieckhusen C, Luz B, et al. Fatal hemolytic disease of the newborn caused by an antibody to KEAL, a new low-prevalence Kell blood group antigen. Transfusion 2017;57:217–8.
Search in Google Scholar Back to article
Hoglund P, Rosengren-Lindquist R, Wikman AT. A severe haemolytic transfusion reaction caused by anti-Lea active at 37°C. Blood Transfus 2013;11:456–9.
Search in Google Scholar Back to article
Irani MS, Figuerona D, Savage G. Acute hemolytic transfusion reaction due to anti-Leb. Transfusion 2015;55:2486–8.
Search in Google Scholar Back to article
Duncan V, Pham HP, Williams LA III. A possible case of haemolytic transfusion reaction caused by anti-Lea antibody. Blood Transfus 2015;13:535–6.
Search in Google Scholar Back to article
PHB Bolton-Maggs (Ed), D Poles et al. on behalf of the Serious Hazards of Transfusion (SHOT) Steering Group. The 2017 Annual SHOT Report (2018). Available from https://www.shotuk.org/wp-content/uploads/myimages/SHOT-Report-2017-WEB-Final-v4-25-9-18.pdf.
Search in Google Scholar Back to article
Poole J, Thornton NM, Tilley L. Novel high incidence antigen in the Diego blood group system (DISK) and clinical significance of anti-DISK (abstract). Vox Sang 2010;99(Suppl 1):30.
Search in Google Scholar Back to article
Laundy R, Karamatic Crew V, Davies H, et al. A novel high incidence antigen in the Yt blood group system (abstract). Transfus Med 2017;27(Suppl 2):42–3.
Search in Google Scholar Back to article
Karamatic Crew V, Laundy R, McNeill A, et al. Serological and molecular characterisation of two novel high frequency antigens in the Yt blood group system (abstract). Vox Sang 2018;113(Suppl 1):63.
Search in Google Scholar Back to article
Baglow L, Laundy R, Karamatic Crew V, et al. Three new unrelated examples of the rare YTEG–phenotype and anti-YTEG (abstract). Transfus Med 2018;28(Suppl 1):40.
Search in Google Scholar Back to article
Thornton N, Karamatic Crew V, Muniz E, et al. Four examples of anti-CD99 and discovery of the molecular bases of the rare CD99–phenotype (abstract). Vox Sang 2015;109(Suppl 1):50.
Search in Google Scholar Back to article

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