Dilution is not the solution: acute hemolytic transfusion reaction after ABO-incompatible pooled platelet transfusion

J. Guarente; M. Harach; J. Gould; J.K. Karp; A.R. Peedin

doi:10.21307/immunohematology-2020-020

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Dilution is not the solution: acute hemolytic transfusion reaction after ABO-incompatible pooled platelet transfusion

Immunohematology

Volume 35 (2019): Issue 3 (September 2019)

By: J. Guarente, M. Harach, J. Gould, J.K. Karp and A.R. Peedin

Paid access

|Feb 2020

Abstract

The short shelf life of platelets makes providing ABO-compatible platelets a challenge, and many institutions issue ABO-incompatible platelets when compatible units are not available. It is presumed that ABO antibodies that exist in donor plasma are diluted when platelets from multiple donors are combined to make a pooled product for transfusion. We present a case of a hemolytic transfusion reaction in a 73-year-old man with myelodysplastic syndrome who received an ABO-incompatible pooled platelet unit. This case report demonstrates that the dilution theory is not always true for pooled platelet units, and any patient receiving ABO-incompatible platelet transfusions must be closely monitored for potential hemolytic transfusion reactions.

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Articles in this issue

DOI: https://doi.org/10.21307/immunohematology-2020-020 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X

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Language: English

Page range: 91 - 94

Published on: Feb 16, 2020

Published by: American National Red Cross

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

platelet transfusion,

acute hemolytic transfusion reaction,

Related subjects:

© 2020 J. Guarente, M. Harach, J. Gould, J.K. Karp, A.R. Peedin, published by American National Red Cross
This work is licensed under the Creative Commons License.

Volume 35 (2019): Issue 3 (September 2019)