Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: a case study and review

Grigoriadis, G.; Condon, J.; Green, K.; Anderson, M.A.; Borosak, M.; Wood, E.

doi:10.21307/immunohematology-2019-179

Abstract

AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWj– phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear. Immunohematology 2011;27:83–88.

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Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: a case study and review

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