The Indian blood group system

Xu, Q.

doi:10.21307/immunohematology-2019-180

Abstract

The Indian blood group system (ISBT: IN/023) consists of two antithetical antigens: In^a(IN1), which is present in approximately 10 percent of some Arab populations and in 3 percent of Bombay Indians, and its allelic antigen In^b(IN2), an antigen of high incidence in all populations. In 2007, two new high-incidence antigens were identified as belonging to the IN blood group system, namely IN3 (INFI) and IN4 (INJA). The antigens in this system are located on CD44, a single-pass membrane glycoprotein that is encoded by the CD44gene on chromosome 11 at position p13. The biologic function of CD44 is as a leukocyte homing receptor and cellular adhesion molecule. The In^aand In^bpolymorphism represents a 252G>C substitution of CD44,encoding R46P, and lack of IN3 and IN4 results from homozygosity for mutations encoding H85Q and T163R in the CD44gene. The high-frequency antigen AnWj (901009) has not been assigned to the Indian system, but either is located on an isoform of CD44 or is closely associated with it. Immunohematology2011;27:89–93.

References

Badakere SS, Joshi SR, Bhatia HM, Desai PK, Giles CM, Goldsmith KL. Evidence for a new blood group antigen in the Indian population (a preliminary report). Indian J Med Res 1973;61:563.
Search in Google Scholar Back to article
Badakere SS, Parab BB, Bhatia HM. Further observations on the In^a(Indian) antigen in Indian populations. Vox Sang 1974;26:400–3.10.1111/j.1423-0410.1974.tb02713.x4842708
Search in Google Scholar Back to article
Giles CM. Antithetical relationship of anti-In^awith the Salis antibody. Vox Sang 1975;29:73–6.10.1111/j.1423-0410.1975.tb00480.x1146277
Search in Google Scholar Back to article
Daniels GL, Anstee DJ, Cartron JP, et al. Blood group terminology 1995. ISBT Working Party on Terminology for Red Cell Surface Antigens. Vox Sang 1995;69:265–79.
Search in Google Scholar Back to article
Poole J, Tilley L, Warke N, et al. Two missense mutations in the CD44gene encode two new antigens of the Indian blood group system [published correction appears in Transfusion 2007;47:1741]. Transfusion 2007;47:1306–11.10.1111/j.1537-2995.2007.01275.x17581168
Search in Google Scholar Back to article
Spring FA, Dalchau R, Daniels GL, et al. The In^aand In^bblood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu)gene. Immunology 1988;64:37–43.
Search in Google Scholar Back to article
Telen MJ, Udani M, Washington MK, Levesque MC, Lloyd E, Rao N. A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. J Biol Chem 1996; 271:7147–53.10.1074/jbc.271.12.71478636151
Search in Google Scholar Back to article
Race RR, Sanger R. Blood groups in man. 6th ed. Oxford: Blackwell Scientific Publications, 1975.
Search in Google Scholar Back to article
Daniels GL. Blood group antigens of high frequency: a serological and genetical study. PhD thesis, University of London, 1980.
Search in Google Scholar Back to article
Poole J, Giles CM. Observations on the Anton antigen and antibody. Vox Sang 1982;43:220–2.10.1111/j.1423-0410.1982.tb00015.x6182694
Search in Google Scholar Back to article
Marsh WL, Brown PJ, Dinapoli J, et al. Anti-Wj: an autoantibody that defines a high-incidence antigen modified by the In(Lu)gene. Transfusion 1983;23:128–30.10.1046/j.1537-2995.1983.23283172849.x6188251
Search in Google Scholar Back to article
Poole J, Giles C. Anton and Wj, are they related (letter)? Transfusion 1985;25:443.10.1111/j.1537-2995.1985.tb01390.x
Search in Google Scholar Back to article
Parsons SF, Jones J, Anstee DJ, et al. A novel form of congenital dyserythropoietic anemia associated with deficiency of erythroid CD44 and a unique blood group phenotype [In(a–b–), Co(a–b–)]. Blood 1994;83:860–8.10.1182/blood.V83.3.860.860
Search in Google Scholar Back to article
Rao N, Udani M, Telen MJ. Demonstration by monoclonal antibody immobilization of erythrocyte antigens and dot blot that both the In and AnWj blood group antigens reside on CD44 [abstract]. Transfusion 1994;34:255.
Search in Google Scholar Back to article
Telen MJ, Rao N, Udani M, Liao H-X, Haynes BF. Relationship of the Wj blood group antigen to expression of CD44 (abstract). Transfusion 1993;33:48S.
Search in Google Scholar Back to article
Badakere SS, Vasantha K, Bhatia HM, et al. High frequency of In^aantigen among Iranians and Arabs. Hum Hered 1980;30:262–3.10.1159/0001531407390518
Search in Google Scholar Back to article
Longster GH, North DI, Robinson EA. Four further examples of anti-In^bdetected during pregnancy. Clin Lab Haematol 1981;3:351–6.
Search in Google Scholar Back to article
Issitt PD, Anstee DJ. Applied blood group serology. 4th ed. Durham, NC: Montgomery Scientific Publications, 1998.
Search in Google Scholar Back to article
Reid ME, Lomas-Francis C. The blood group antigen factsbook. 2nd ed. San Diego, CA: Academic Press, 2003.10.1016/B978-012586585-2/50007-X
Search in Google Scholar Back to article
Ferguson DJ, Gaal HD. Some observations on the In^bantigen and evidence that anti-In^bcauses accelerated destruction of radiolabeled red cells. Transfusion 1988;28:479–82.10.1046/j.1537-2995.1988.28588337342.x
Search in Google Scholar Back to article
Poole J, Levene C, Bennett M, Sela R, van Alphen L, Spruell PJ. A family showing inheritance of the Anton blood group antigen AnWj and independence of AnWj from Lutheran. Transfus Med 1991;1:245–51.10.1111/j.1365-3148.1991.tb00040.x
Search in Google Scholar Back to article
Lukasavage T. Donor screening with anti-AnWj (letter). Immunohematology 1993;9:112.
Search in Google Scholar Back to article
Goodfellow PN, Banting G, Wiles MV, et al. The gene, MIC4, which controls expression of the antigen defined by monoclonal antibody F10.44.2, is on human chromosome 11. Eur J Immunol 1982;12:659–63.10.1002/eji.1830120807
Search in Google Scholar Back to article
Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci U S A 1992;89:12160–4.10.1073/pnas.89.24.12160
Search in Google Scholar Back to article
Tölg C, Hofmann M, Herrlich P, Ponta H. Splicing choice from ten variant exons establishes CD44 variability. Nucleic Acids Res 1993;21:1225–9.10.1093/nar/21.5.1225
Search in Google Scholar Back to article
Goldstein LA, Zhou DF, Picker LJ, et al. A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell 1989;56:1063–72.10.1016/0092-8674(89)90639-9
Search in Google Scholar Back to article
Daniels G. Human blood groups. 2nd ed. Oxford: Blackwell Science, 2002.10.1002/9780470987018
Search in Google Scholar Back to article
Dalchau R, Kirkley J, Fabre JW. Monoclonal antibody to a human brain-granulocyte-T lymphocyte antigen probably homologous to the W 3/13 antigen of the rat. Eur J Immunol 1980;10:745–9.10.1002/eji.18301010046968681
Search in Google Scholar Back to article
Bhatia HM, Badakere SS, Mokashi SA, Parab BB. Studies on the blood group antigen In^a. Immunol Commun 1980;9: 203–15.10.3109/088201380090659946772546
Search in Google Scholar Back to article
Joshi SR, Gupta D, Choudhury RK, Choudhury N. Transfusion-induced anti-In^afollowing a single-unit transfusion. Transfusion 1993;33:444.10.1046/j.1537-2995.1993.33593255610.x8488553
Search in Google Scholar Back to article
Joshi SR. Immediate haemolytic transfusion reaction due to anti-In^b. Vox Sang 1992;63:232–3.10.1111/j.1423-0410.1992.tb05107.x1448968
Search in Google Scholar Back to article
Sosler SD, Saporito C, Perkins JT, Unger PJ, Orlina AR. The clinical and serologic behavior of another example of anti-In^b (letter). Transfusion 1989;29:465.10.1046/j.1537-2995.1989.29589284154.x2734828
Search in Google Scholar Back to article
Garner SF, Devenish A. Do monocyte ADCC assays accurately predict the severity of hemolytic disease of the newborn caused by antibodies to high-frequency antigens? Immunohematology 1996;12:20–6.10.21307/immunohematology-2019-741
Search in Google Scholar Back to article
Magrin G, Harrison C. One hour 51Cr survival in a patient with anti-Wj (abstract). Proceedings of the 20th Congress of the International Society of Blood Transfusion (London, 1988). 1988:228.
Search in Google Scholar Back to article
de Man AMJ, van Dijk BA, Daniels GL. An example of anti-AnWj causing haemolytic transfusion reaction (letter). Vox Sang 1992;63:238.10.1159/000462272
Search in Google Scholar Back to article
Fitzsimmons J, Caggiano V. Autoantibody to a high frequency Lutheran antigen associated with immune hemolytic anemia and a hemolytic transfusion episode (abstract). Transfusion 1981;21:612.
Search in Google Scholar Back to article
Whitsett CF, Hare VW, Oxendine SM, Pierce JA. Autologous and allogeneic red cell survival studies in the presence of autoanti-AnWj. Transfusion 1993;33:845–7.10.1046/j.1537-2995.1993.331094054624.x8236428
Search in Google Scholar Back to article

The Indian blood group system

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