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Rituximab in the treatment of Pembrolizumab induced Myasthenia Gravis Cover

Rituximab in the treatment of Pembrolizumab induced Myasthenia Gravis

Open Access
|Jul 2022

Abstract

Pembrolizumab is a monoclonal antibody programmed cell death 1 inhibitor that is an established treatment for melanoma and various lung cancers. Whilst an effective treatment option, it is known to have multiple immune related adverse events associated with its use, including neurological complications such as myasthenia gravis. Previous case reports on the treatment of Pembrolizumab induced myasthenia gravis have detailed the difficulty in managing the condition. There is increasing evidence that Rituximab, a monoclonal antibody directed at CD20 antigen B cells may be an effective treatment option for this condition. This case report outlines the successful treatment of a patient with Pembrolizumab induced myasthenia gravis who was managed with Rituximab.

DOI: https://doi.org/10.21307/ajon-2022-002 | Journal eISSN: 2208-6781 | Journal ISSN: 1032-335X
Language: English
Page range: 5 - 11
Published on: Jul 11, 2022
Published by: Australasian Neuroscience Nurses Association
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2022 Jessica C. O’Keeffe, Nadia Deborah Friedman, Sujith Ayyappan, published by Australasian Neuroscience Nurses Association
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.