References
- Abbott T.R., Qi L.S. et al.: Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza. Cell, 181, 865–876.e12 (2020)
- Abudayyeh O.O., Zhang F. et al.: RNA targeting with CRISPR-Cas13. Nature, 550, 280–284 (2017)
- Ahmed A., Wilcox R.A. et al.: Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trial. Lancet Haematol, 6, e630–e637 (2019)
- Albeituni S., Verbist K.C., Tedrick P.E., Tillman H., Picarsic J., Bassett R., Nichols K.E.: Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis. Blood, 134, 147–159 (2019)
- Andreani J., Raoult D. et al.: In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect. Microb. Pathog. 145, 104228 (2020)
- Antinori S., Galli M. et al.: Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post_treatment hospitalisation status. Pharmacol. Res, 158, 104899–104899 (2020)
- Antwi-Amoabeng D., Kanji Z., Ford B., Beutler B.D., Riddle M.S., Siddiqui F.: Clinical Outcomes in COVID-19 Patients Treated with Tocilizumab: An Individual Patient Data Systematic Review. J. Med. Virol. (2020)
- Atal S., Fatima Z.: IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? Pharmaceut. Med. 1–9 (2020)
- Báez-Santos Y.M., St John S.E., Mesecar A.D.: The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Res. 115, 21–38 (2015)
- Barnard D.L., Sidwell R.W. et al.: Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res. 71, 53–63 (2006)
- Batlle D., Wysocki J., Satchell K.: Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy? Clini. Sci. 134, 543–545 (2020)
- Becares M., Pascual-Iglesias A., Nogales A., Sola I., Enjuanes L., Zuñiga S.: Mutagenesis of coronavirus nsp14 reveals its potential role in modulation of the innate immune response. J. Virol, 90, 5399–5414 (2016)
- Bechman K., Subesinghe S., Norton S., Atzeni F., Galli M., Cope A.P., Winthrop K.L., Galloway J.B.: A systematic review and meta-analysis of infection risk with small molecule JAK inhibitors in rheumatoid arthritis. Rheumatology, 58, 1755–1766 (2019)
- Beck B.R., Shin B., Choi Y., Park S., Kang K.: Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model. Comput. Struct. Biotechnol. J. 18, 784–790 (2020)
- Beigel J.H., Tomashek K.M., Dodd L.E.: Remdesivir for the Treatment of Covid-19 – Preliminary Report. N. Engl. J. Med. (2020)
- Binois Y., Hachad H., Salem J.-E., Charpentier J., Lebrun-Vignes B., Pène F., Cariou A., Chiche J.-D., Mira J.-P., Nguyen L.S.: Acute kidney injury associated with lopinavir/ritonavir combined therapy in patients with Covid-19. Kidney Int. Rep. (2020)
- Blaising J., Lévy P.L., Polyak S.J., Stanifer M., Boulant S., Pécheur E.-I.: Arbidol inhibits viral entry by interfering with| clathrin-dependent trafficking. Antiviral Res. 100, 215–219 (2013)
- Blaising J., Polyak S.J., Pécheur E.-I.: Arbidol as a broad-spectrum antiviral: An update. Antiviral Res. 107, 84–94 (2014)
- Boriskin Y.S., Leneva I.A., Pécheur E.I., Polyak S.: Arbidol: A Broad-Spectrum Antiviral Compound that Blocks Viral Fusion. Curr. Med. Chem, 15, 997–1005 (2008)
- Bouvet M., Debarnot C., Imbert I., Selisko B., Snijder E.J., Canard B., Decroly E.: In vitro reconstitution of SARS-coronavirus mRNA cap methylation. PLoS Path, 6, e1000863-e1000863 (2010)
- Broglie L., Pommert L., Rao S., Thakar M., Phelan R., Margolis D., Talano J.: Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis. Blood advances, 1, 1533–1536 (2017)
- Bryan M.C., Rajapaksa N.S.: Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances. J. Med. Chem. 61, 9030–9058 (2018)
- Cai Q., Liu L. et al.: Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study. Engineering, (2020)
- Caly L., Druce J.D., Catton M.G., Jans D.A., Wagstaff K.M.: The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 178, 104787 (2020)
- Cantini F., Niccoli L., Matarrese D., Nicastri E., Stobbione P., Goletti D.: Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact. J. Infec. 81, 318–356 (2020)
- Cao B., Wang C. et al.: A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N. Engl. J. Med. 382, 1787–179 (2020)
- Cao Y., Zhou J. et al.: Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial. J. Allergy Clin. Immunol. 146, 137–146.e133 (2020)
- Capochiani E., Bocchia M. et al.: Ruxolitinib Rapidly Reduces Acute Respiratory Distress Syndrome in COVID-19 Disease. Analysis of Data Collection From RESPIRE Protocol. Front. Med, 7, 466 (2020)
- Casadevall A., Pirofski L.-A.: The convalescent sera option for containing COVID-19. J. Clin. Invest. 130, 1545–1548 (2020)
- Chaccour C., Hammann F., Ramón-García S., Rabinovich N.R.: Ivermectin and COVID-19: Keeping Rigor in Times of Urgency. Am. J. Trop. Med. Hyg. 102, 1156–1157 (2020)
- Chaccour C., Hammann F., Ramón-García S., Rabinovich N.R.: Ivermectin and Novel Coronavirus Disease (COVID-19): Keeping Rigor in Times of Urgency. Am. J. Trop. Med. Hyg.(2020)
- Chan J.F.-W., Yuen K.-Y. et al.: Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset. J. Inf. Dis. 212, 1904–1913 (2015)
- Chandwani A., Shuter J.: Lopinavir/ritonavir in the treatment of HIV-1 infection: a review. Ther. Clin. Risk Manag. 4, 1023–1033 (2008)
- Chao J.Y., Derespina K.R., Herold B.C., Goldman D.L., Aldrich M., Weingarten J., Ushay H.M., Cabana M.D., Medar S.S.: Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 (COVID-19) at a Tertiary Care Medical Center in New York City. J. Ped. 223, 14–19.e2 (2020)
- Chen C., Wang X. et al.: Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial. medRxiv, 2020.2003. 2017.20037432 (2020)
- Chen J., Lu H. et al.: A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19). J. Zhejiang University (Med. Sci.), 49 (2020)
- Chen L., Xiong J., Bao L., Shi Y.: Convalescent plasma as a potential therapy for COVID-19. Lancet Infect. Dis. 20, 398–400 (2020)
- Chen Y., Guo D.: Molecular mechanisms of coronavirus RNA capping and methylation. Virologica Sinica, 31, 3–11 (2016)
- Chen Y., Guo D. et al.: Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2′-O-methylation by nsp16/nsp10 protein complex. PLoS Path. 7, e1002294–e1002294 (2011)
- Chowdhury M.D.S., Rathod J., Gernsheimer J.: A Rapid Systematic Review of Clinical Trials Utilizing Chloroquine and Hydroxychloroquine as a Treatment for COVID-19. Acad. Emerg. Med. 27, 493–504 (2020)
- Choy K.-T., Yen H.-L. et al.: Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 178, 104786 (2020)
- Colaneri M., Bogliolo L., Valsecchi P., Sacchi P., Zuccaro V., Brandolino F., Montecucco C., Mojoli F., Giusti E.M., Bruno R.: Tocilizumab for treatment of severe COVID-19 patients: preliminary results from SMAtteo COvid19 REgistry (SMACORE). Microorganisms, 8, (2020)
- Cyranoski D.: China is promoting coronavirus treatments based on unproven traditional medicines. Nature, (2020).
- Dastan F., Tabarsi P. et al.: Promising Effects of Tocilizumab in COVID-19: A Non-Controlled, Prospective Clinical Trial. Int. Immunopharmacol. 88, 106869 (2020)
- Deng L., Li C., Zeng Q., Liu X., Li X., Zhang H., Hong Z., Xia J.: Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study. J. Infect. 81, e1–e5 (2020)
- Duan K., Yang X. et al.: Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc. Nat. Acad. Sci. USA, 117, 9490–9496 (2020)
- Durante-Mangoni E., Andini R., Bertolino L., Mele F., Florio L.L., Murino P., Corcione A., Zampino R.: Early experience with remdesivir in SARS-CoV-2 pneumonia. Infection, 1–4 (2020)
- Elfiky A.A.: Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, )and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci. 253, 117592–117592 (2020)
- Falzarano D., de Wit E., Martellaro C., Callison J., Munster V.J., Feldmann H.: Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin. Sci. Rep. 3, 1686–1686 (2013)
- Falzarano D., Feldmann H. et al.: Treatment with interferon-alpha 2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques. Nat. Med. 10, 1313–7 (2013)
- Fantini J., Di Scala C., Chahinian H., Yahi N.: Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection. Int. J. Antimicrob. Agents, 55, 105960 (2020)
- Favalli E.G., Biggioggero M., Maioli G., Caporali R.: Baricitinib for COVID-19: a suitable treatment? Lancet Infect. Dis. 9, 1012–1013 (2020)
- Franzetti M., Piconi S. et al.: Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report. Int. J. Infect.Dis. 97, 215–218 (2020)
- Freije C.A., Sabeti P.C. et al.: Programmable Inhibition and Detection of RNA Viruses Using Cas13. Mol. Cell, 76, 826–837.e811 (2019)
- Furuta Y., Komeno T., Nakamura T.: Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase. Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 93, 449–463 (2017)
- Gao J., Tian Z., Yang X.: Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. BioSci. Trends, 14, 72–73 (2020)
- Gaspari V., Zengarini C., Greco S., Vangeli V., Mastroianni A.: Side effects of ruxolitinib in patients with SARS-CoV-2 infection: Two case reports. Int. J. Antimicrob. Agents, 56, 106023–106023 (2020)
- Gautret P., Raoult D. et al.: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int. J. Antimicrob. Agents, 56, 105949 (2020)
- George J., Mattapallil J.J.: Interferon-α Subtypes As an Adjunct Therapeutic Approach for Human Immunodeficiency Virus Functional Cure. Front. Immun. 9, 299–299 (2018)
- Gharbharan A., Rijnders B. et al.: Convalescent Plasma for COVID-19. A randomized clinical trial. medRxiv, 2020.2007. 2001.20139857 (2020)
- Goldman J.D., Subramanian A. et al.: Remdesivir for 5 or 10 Days in Patients with Severe Covid-19. N. Engl. J. Med. (2020)
- Gordon C.J., Tchesnokov E.P., Woolner E., Perry J.K., Feng J.Y., Porter D.P., Gotte M.: Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. J. Biol. Chem. 295, 6785–6797. (2020)
- Gorial F.I., Mashhadani S., Sayaly H.M., Dakhil B.D., AlMashhadani M.M., Aljabory A.M., Abbas H.M., Ghanim M., Rasheed J.I.: Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial). medRxiv, 2020.2007.2007.20145979 (2020)
- Grein J., Flanigan T. et al.: Compassionate Use of Remdesivir for Patients with Severe Covid-19. N. Engl. J. Med. 382, 2327–2336 (2020)
- Gu H., Yang P. et al.: Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci. Rep. 6, 19840 (2016)
- Haagmans B.L., Osterhaus A.D.M.E. et al.: Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques. Nat. Med. 10, 290–293 (2004)
- Habib A.M.G., Ali M.A.E., Zouaoui B.R., Taha M.A.H., Mohammed B.S., Saquib N.: Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. BMC Infect. Dis. 19, 870–870 (2019)
- Harigai M., Genovese M.C. et al.: FRI0077 Hepatitis b virus reactivation in patients with rheumatoid arthritis treated with baricitinib: post-hoc analysis from clinical trials. Ann. Rheumatic Dis. 77 (2018)
- Hartwell D., Jones J., Baxter L., Shepherd J.: Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment, re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation. Health Technol. Assess. 17, i-xii, 1–210 (2011)
- Haschke M., Schuster M., Poglitsch M., Loibner H., Salzberg M., Bruggisser M., Penninger J., Krähenbühl S.: Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clin. Pharmacokinet. 52, 783–792 (2013)
- He R., Adonov A., Traykova-Adonova M., Cao J., Cutts T., Grudesky E., Deschambaul Y., Berry J., Drebot M., Li X.: Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid. Biochem. Biophys. Res. Commun. 320, 1199–1203 (2004)
- Hemnes A.R., West J. et al.: A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. Europ. Respir. J. 51, 1702638 (2018)
- Hensley L.E., Fritz L.E., Jahrling P.B., Karp C.L., Huggins J.W., Geisbert T.W.: Interferon-beta 1a and SARS coronavirus replication. Emerg. Infect. Dis. 10, 317–319 (2004)
- Hoffmann M., Pöhlmann S. et al.: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181, 271–280.e278 (2020)
- Hoffmann M., Schroeder S., Kleine-Weber H., Müller M.A., Drosten C., Pöhlmann S.: Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19. Antimicrob. Agents Chemother. 64, e00754–00720 (2020)
- Horby P., Landry M. et al.: Effect of hydroxychloroquine in hospitalized patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial. medRxiv, 2020.2007.2015.20151852 (2020)
- Huang F., Luo L. et al.: A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19). Pharmacol. Res. 104929 (2020)
- Huang Y.-Q., Chen Y.-K. et al.: No Statistically Apparent Difference in Antiviral Effectiveness Observed Among Ribavirin Plus Interferon-Alpha, Lopinavir/Ritonavir Plus Interferon-Alpha, and Ribavirin Plus Lopinavir/Ritonavir Plus Interferon-Alpha in Patients With Mild to Moderate Coronavirus Disease 2019: Results of a Randomized, Open-Labeled Prospective Study. Front. Pharmacol. 11, 1071–1071 (2020)
- Hung I.F.-N., Yuen K.-Y. et al.: Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet, 395, 1695–1704 (2020)
- Iwata-Yoshikawa N., Okamura T., Shimizu Y., Hasegawa H., Takeda M., Nagata N.: TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection. J. Vir. 93, e01815–01818 (2019)
- Jacobs M., Thomson E.C. et al: Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet, 388, 498–503 (2016)
- Jin X., Guo D. et al.: Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP. Virus Res. 176, 45–52 (2013)
- Jin Y.-H., Wang X.-H. et al.: A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil. Med. Res. 7, 4 (2020)
- Jomah S., Asdaq S.M.B., Al-Yamani M.J.: Clinical efficacy of antivirals against novel coronavirus (COVID-19): A review. J. Infect. Public Health, 9, 1187–1195 (2020)
- Joumaa H., Regard L., Carlier N., Chassagnon G., Alabadan E., Canouï E., L’Honneur A., Rozenberg F., Burgel P.R., Roche N.: A severe COVID-19 despite ongoing treatment with Lopinavir-Ritonavir. Respi. Med. Res. 78, 100780 (2020)
- Karres I., Kremer J.P., Dietl I., Steckholzer U., Jochum M., Ertel W.: Chloroquine inhibits proinflammatory cytokine release into human whole blood. Am. J. Physiol. 274, R1058–1064 (1998)
- Kawase M., Shirato K., van der Hoek L., Taguchi F., Matsuyama S.: Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry. J. Vir. 86, 6537–6545 (2012)
- Khalili J., Zhu H., Mak A., Yan Y., Zhu Y.: Novel coronavirus treatment with ribavirin: Groundwork for evaluation concerning COVID-19. J. Med. Vir. (2020)
- Khambholja K., Asudani D.: Potential repurposing of Favipiravir in COVID-19 outbreak based on current evidence. Travel Med. Infecti. Dis. 35, 101710 (2020)
- Khamitov R.A., Loginova S., Shchukina V.N., Borisevich S.V., Maksimov V.A., Shuster A.M.: Antiviral activity of arbidol and its derivatives against the pathogen of severe acute respiratory syndrome in the cell cultures. Vopr. Virusol. 53, 9–13 (2008)
- Khan R.J., Jha R.K., Amera G.M., Jain M., Singh E., Pathak A., Singh R.P., Muthukumaran J., Singh A.K.: Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase. J. Biomol. Struct. Dyn. 0, 1–14 (2020)
- Ko G.M., Reddy A.S., Kumar S., Bailey B.A., Garg R.: Computational analysis of HIV-1 protease protein binding pockets. J. Chem. Inform. Model. 50, 1759–1771 (2010)
- Kobayashi T., Nakatsuka K., Shimizu M., Tamura H., Shinya E., Atsukawa M., Harimoto H., Takahashi H., Sakamoto C.: Ribavirin modulates the conversion of human CD4(+) CD25(–) T cell to CD4(+) CD25(+) FOXP3(+) T cell via suppressing interleukin-10-producing regulatory T cell. Immunol. 137, 259–270 (2012)
- Kong Y., Cai C., Ling L., Zeng L., Wu M., Wu Y., Zhang W., Liu Z.: Successful treatment of a centenarian with coronavirus disease 2019 (COVID-19) using convalescent plasma. Transf. Apheres. Sci. 102820 (2020)
- Koren G., King S., Knowles S., Phillips E.: Ribavirin in the treatment of SARS: A new trick for an old drug? CMAJ, 168, 1289–1292 (2003)
- Krilov L.: Safety issues related to the administration of ribavirin. Pediatr. Infec. Dis. J. 21, 479–481 (2002)
- Kuznik A., Bencina M., Svajger U., Jeras M., Rozman B., Jerala R.: Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J. Immunol. 186, 4794–4804 (2011)
- La Rosée F., La Rosée P. et al.: The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation. Leukemia, 34, 1805–1815 (2020)
- Laing R., Gillan V., Devaney E.: Ivermectin – Old Drug, New Tricks? Trends Parasitol. 33, 463–472 (2017)
- Lecronier M., Dres M. et al.: Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis. Crit. Care, 24, 418–418 (2020)
- Lee C.: CRISPR/Cas9-Based Antiviral Strategy: Current Status and the Potential Challenge. Molecules, 24, 1349 (2019)
- Lee J.Y., Kim Y.-J., Chung E.H., Kim D.-W., Jeong I., Kim Y., Yun M.-R., Kim S.S., Kim G., Joh J.-S.: The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea, 2015. BMC Infect. Dis. 17, 498–498 (2017)
- Lei C., Fu W., Qian K., Li T., Zhang S., Fu W., Ding M., Hu S.: Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig. Nat. Commun. 11, 2070 (2020)
- Li W., Moore M.J., Vasilieva N., Sui J., Wong S.K., Berne M.A., Somasundaran M., Sullivan J.L., Luzuriaga K., Greenough T.C. et al: Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 426, 450–454 (2003)
- Li Y., Li L. et al.: An exploratory randomized controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI). medRxiv, 2020.2003.2019.20038984 (2020)
- Lian N., Xie H., Lin S., Huang J., Zhao J., Lin Q.: Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective study. Clin. Microbiol. Infect. 26, 917–921 (2020)
- Lin S., Shen R., He J., Li X., Guo X.: Molecular modeling evaluation of the binding effect of ritonavir, lopinavir and darunavir to severe acute respiratory syndrome Coronavirus 2 proteases. bioRxiv, 2020.2001.2031.929695 (2020)
- Liu Q., Peng P. et al.: The effect of Arbidol Hydrochloride on reducing mortality of Covid-19 patients: a retrospective study of real world date from three hospitals in Wuhan. medRxiv, 2020.2004.2011.20056523 (2020)
- Liu S., Lien C.Z., Selvaraj P., Wang T.T.: Evaluation of 19 antiviral drugs against SARS-CoV-2 Infection. bioRxiv, 2020.2004. 2029.067983 (2020)
- Lou Y., Liu L., Qiu Y.: Clinical outcomes and plasma concentrations of baloxavir marboxil and favipiravir in COVID-19 patients: an exploratory randomized, controlled trial. medRxiv, 2020.2004.2029.20085761 (2020)
- Loutfy M.R., Fish E. N. et al.: Interferon Alfacon-1 Plus Corticosteroids in Severe Acute Respiratory Syndrome A Preliminary Study. JAMA, 290, 3222–3228 (2003)
- Lu H., Stratton C.W., Tang Y.-W.: Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J. Med. Vir. 92, 401–402 (2020)
- Lucas J.M., Nelson P.S. et al.: The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 4, 1310–1325 (2014)
- Luo P., Liu Y., Qiu L., Liu X., Liu D., Li J.: Tocilizumab treatment in COVID-19: A single center experience. J. Med. Virol. 92, 814–818 (2020)
- Kowalik M.M., Trzonkowski P., Łasińska-Kowara M., Mital A., Smiatacz T., Jaguszewski M.: COVID-19 – Toward a comprehensive understanding of the disease. Cardiol. J. 27, 99–114 (2020)
- Madrid P.B., Tanga J. et al.: Evaluation of Ebola Virus Inhibitors for Drug Repurposing. ACS Infect. Dis. 1, 317–326 (2015)
- Maggio R., Corsini G.U.: Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection. Pharmacolog. Res. 104837 (2020)
- Mahévas M., Costedoat-Chalumeau N. et al: Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data. BMJ, 369, m1844 (2020)
- Mair-Jenkins J., Beck C.R. et al.: The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis. J. Infect. Dis. 211, 80–90 (2015)
- Matsuyama S., Takeda M. et al.: Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells. Proc. Nat. Acad. Sci. USA, 117, 7001 (2020)
- McAuliffe J., Subbarao K. et al.: Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys. Virology, 330, 8–15 (2004)
- Mehra M.R., Desai S.S., Ruschitzka F., Patel A.N.: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. Lancet, RETRACTED (2020)
- Mehta P., McAuley D.F., Brown M., Sanchez E., Tattersall R.S., Manson J.J.: COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet, 395, 1033–1034 (2020)
- Minato T., Kuba K. et al.: B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nat. Commun. 11, 1058–1058 (2020)
- Miyamoto Y., Yamada K., Yoneda Y.: Importin α: a key molecule in nuclear transport and non-transport functions. J. Biochem. 160, 69–75 (2016)
- Mo Y., Fisher D.: A review of treatment modalities for Middle East Respiratory Syndrome. J. Antimicrob. Chemother. 71, 3340–3350 (2016)
- Molina J.M., Delaugerre C., Le Goff J., Mela-Lima B., Ponscarme D., Goldwirt L., de Castro N.: No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection. Méd. Mal. Infect. 50, 384 (2020)
- Monteil V., Penninger J.M. et al.: Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell, 181, 905–913.e7 (2020)
- Navarro G., Taroumian S., Barroso N., Duan L., Furst D.: Tocilizumab in rheumatoid arthritis: a meta-analysis of efficacy and selected clinical conundrums. Semin. Arthritis Rheum. 43, 458–469 (2014)
- Nutho B., Mahalapbutr P., Hengphasatporn K., Pattaranggoon N.C., Simanon N., Shigeta Y., Hannongbua S., Rungrotmongkol T.: Why are lopinavir and ritonavir effective against the newly emerged coronavirus 2019? atomistic insights into the inhibitory mechanisms. Biochemistry, (2020)
- Nyström K., Waldenström J., Tang K.-W., Lagging M.: Ribavirin: pharmacology, multiple modes of action and possible future perspectives. Fut. Virol. 14, 153–160 (2019)
- Omrani A.S., Saad M.M., Baig K., Bahloul A., Abdul-Matin M., Alaidaroos A.Y., Almakhlafi G.A., Albarrak M.M., Memish Z.A., Albarrak A.M.: Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study. Lancet Infect. Dis. 14, 1090–1095 (2014)
- Ou X., Qian Z. et al.: Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat. Commun. 11, 1620 (2020)
- Padhi A., Seal A., Tripathi T.: How does Arbidol Inhibit the Novel Coronavirus SARS-CoV-2? Atomistic Insights from Molecular Dynamics Simulations; ChemRxiv, PREPRINT (2020)
- Patrizia A., Pierluigi B., Vincenzo d.A., Giustina D.S., Luca M., Angelo O.: Position paper on the preparation of immune plasma to be used in the treatment of patients with COVID-19. Transfus. Apher. Sci. 59, 102817 (2020)
- Peng F., Tu L., Yang Y., Hu P., Wang R., Hu Q., Cao F., Jiang T., Sun J., Xu G. et al: Management and Treatment of COVID-19: The Chinese Experience. Can. J. Cardiol. 36, 915–930 (2020)
- Pilkington V., Pepperrell T., Hill A.: A review of the safety of favipiravir – a potential treatment in the COVID-19 pandemic? J. Virus Erad. 6, 45–51 (2020)
- Praveen D., Puvvada R.C., M V.A.: Janus kinase inhibitor baricitinib is not an ideal option for management of COVID-19. Int. J. Antimicrob. Agents, 55, 105967–105967 (2020)
- Qaseem A., Yost J., Etxeandia-Ikobaltzeta I., Miller M.C., Abraham G.M., Obley A.J., Forciea M.A., Jokela J.A., Humphrey L.L.: Should clinicians use chloroquine or hydroxychloroquine alone or in combination with azithromycin for the prophylaxis or treatment of COVID-19? Living practice points from the american college of physicians (Version 1). Ann. Intern. Medi. 173, 137–142 (2020)
- Radbel J., Narayanan N., Bhatt P.J.: Use of Tocilizumab for COVID-19-Induced Cytokine Release Syndrome: A Cautionary Case Report. Chest, 158, e15–e19 (2020)
- Raimondo M.G., Biggioggero M., Crotti C., Becciolini A., Favalli E.G.: Profile of sarilumab and its potential in the treatment of rheumatoid arthritis. Drug Des. Devel. Ther. 11, 1593–1603 (2017)
- Ramanathan A., Robb G.B., Chan S.-H.: mRNA capping: biological functions and applications. Nucleic Acids Res. 44, 7511–7526 (2016)
- Randall R., Goodbourn S.: Interferons and viruses: An interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol. 89, 1–47 (2008)
- Rattanaumpawan P., Jirajariyavej S., Lerdlamyong K., Palavutitotai N., Saiyarin J.: Real-world experience with favipiravir for treatment of COVID-19 in Thailand: Results from a multi-center observational study. medRxiv, 2020.2006.2024.20133249 (2020)
- Retallack H., DeRisi J.L. et al.: Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc. Nat. Acad. Sci. USA, 113, 14408 (2016)
- Richardson P., Griffin I., Tucker C., Smith D., Oechsle O., Phelan A., Stebbing J.: Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. Lancet, 395, e30–e31 (2020)
- Rijckborst V., Janssen H.L.A.: The Role of Interferon in Hepatitis B Therapy. Curr. Hepat. Rep. 9, 231–238 (2010)
- Rolain J.-M., Colson P., Raoult D.: Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century. Int. J. Antimicrob. Agents, 30, 297–308 (2007)
- Sallard E., Lescure F.-X., Yazdanpanah Y., Mentre F., Peiffer-Smadja N.: Type 1 interferons as a potential treatment against COVID-19. Antiviral Res. 178, 104791–104791 (2020)
- Savarino A., Boelaert J.R., Cassone A., Majori G., Cauda R.: Effects of chloroquine on viral infections: an old drug against today’s diseases? Lancet Infect. Dis. 3, 722–727 (2003)
- Shalhoub S., Farahat F., Al-Jiffri A., Simhairi R., Shamma O., Siddiqi N., Mushtaq A.: IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study. J. Antimicrob. Chemother. 70, 2129–2132 (2015)
- Sharma A.: Chloroquine Paradox May Cause More Damage Than Help Fight COVID-19. Microbes Infect. 22, 154–156 (2020)
- Sheahan T.P., Baric R.S. et al.: Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat. Commun. 11, 222–222 (2020)
- Shen C., Liu L. et al.: Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA, 323, 1582–1589 (2020)
- Shen L.W., Mao H.J., Wu Y.L., Tanaka Y., Zhang W.: TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections. Biochimie, 142, 1–10 (2017)
- Shi L., Xiong H., He J., Deng H., Li Q., Zhong Q., Hou W., Cheng L., Xiao H., Yang Z.: Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo. Arch. Virol. 152, 1447–1455 (2007)
- Shirato K., Kawase M., Matsuyama S.: Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry. Virology, 517, 9–15 (2018)
- Sin J.H., Zangardi M.L.: Ruxolitinib for secondary hemophagocytic lymphohistiocytosis: First case report. Hematol. Oncol. Stem Cell Ther. 12, 166–170 (2019)
- Stebbing J., Corebellino M. et al.: Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients. EMBO Mol. Med. 12, e12697 (2020)
- Stebbing J., Phelan A., Griffin I., Tucker C., Oechsle O., Smith D., Richardson P.: COVID-19: combining antiviral and anti-inflammatory treatments. Lancet Infect. Dis. 20, 400–402 (2020)
- Ströher U., DiCaro A., Li Y., Strong J.E., Aoki F., Plummer F., Jones S.M., Feldmann H.: Severe Acute Respiratory Syndrome-Related Coronavirus Is Inhibited by Interferon-α. J. Infect. Dis. 189, 1164–1167 (2004)
- Talukdar R., Tandon R.K.: Pancreatic stellate cells: New target in the treatment of chronic pancreatitis. J. Gastroenterol. Hepatol. 23, 34–41 (2008)
- Tam R.C., Pai B., Bard J., Lim C., Averett D.R., Phan U.T., Milovanovic T.: Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile. J. Hepatol. 30, 376–382 (1999)
- Tang W., Xie Q. et al.: Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. BMJ, 369, m1849 (2020)
- Timani K.A., Zhu Y. et al.: Nuclear/nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus. Virus Res. 114, 23–34 (2005)
- Tipnis S., Hooper N., Hyde R., Karran E.H., Christie G., Turner A.J.: A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J. Biol. Chem. 275, 33238–33243 (2000)
- Tong S., Su Y., Yu Y., Wu C., Chen J., Wang S., Jiang J.: Ribavirin therapy for severe COVID-19: a retrospective cohort study. Int. J. Antimicrob. Agents, 56, 106114–106114 (2020)
- Treml B., Loeckinger A. et al.: Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. Crit. Care Med. 38, 596–601 (2010)
- Tu Y.-F., Chien C.-S., Yarmishyn A., Lin Y.-Y., Luo Y.-H., Lin Y.-T., Lai W.-Y., Yang D.-M., Chou S.-J., Yang Y.-P. et al.: A Review of SARS-CoV-2 and the ongoing clinical trials. Int. J. Mol. Sci. 21, 2657 (2020)
- Ujike M., Nishikawa H., Otaka A., Yamamoto N., Yamamoto N., Matsuoka M., Kodama E., Fujii N., Taguchi F.: Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway. J. Virol. 82, 588 (2008)
- Uno Y.: Camostat mesilate therapy for COVID-19. Intern. Emerg. Med. 1–2 (2020)
- van Kraaij T.D.A., Mostard R.L., Ramiro S., Magro Checa C., van Dongen C.M., van Haren E.H., Buijs J., Landewé R.B.: Tocilizumab in Severe COVID-19 Pneumonia and Concomitant Cytokine Release Syndrome. Eur. J. Case Rep. Int. Med. 7, 001675–001675 (2020)
- van Rhee F., Kurzrock R. et al.: Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman’s disease. J. Clin. Oncol. 28, 3701–3708 (2010)
- Vincent M.J., Bergeron E., Benjannet S., Erickson B.R., Rollin P.E., Ksiazek T.G., Seidah N.G., Nichol S.T.: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol. J. 2, 69–69 (2005)
- Wagstaff K.M., Sivakumaran H., Heaton S.M., Harrich D., Jans D.A.: Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. Biochem. J. 443, 851–856 (2012)
- Wan S., Chen Y. et al.: Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP). medRxiv, 2020.2002.2010.20021832 (2020)
- Wang J., Wang Y., Wu L., Wang X., Jin Z., Gao Z., Wang Z.: Ruxolitinib for refractory/relapsed hemophagocytic lymphohistiocytosis. Haematologica, 105, e210–e212 (2019)
- Wang M., Cao R., Zhang L., Yang X., Liu J., Xu M., Shi Z., Hu Z., Zhong W., Xiao G.: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30, 269–271 (2020)
- Wang X., Cao R., Zhang H., Liu J., Xu M., Hu H., Li Y., Zhao L., Li W., Sun X. et al: The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 6, 28 (2020)
- Wang X., Xu W., Hu G., Xia S., Sun Z., Liu Z., Xie Y., Zhang R., Jiang S., Lu L.: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion. Cell. Mol. Immunol. RETRACTED (2020)
- Wang Y., He Z. et al.: Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret). Biomed. Pharmacother. 91, 393–401 (2017)
- Wang Y., Guo D. et al.: Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. J. Virol. 89, 8416–8427 (2015)
- Wang Y., Wang C. et al.: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet, 395, 1569–1578 (2020)
- Wang Y., Wang C. et al.: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet, 395, 1569–1578 (2020)
- Wang Z., Chen X., Lu Y., Chen F., Zhang W.: Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. BioScience Trends, 14, 64–68 (2020)
- Williamson B.N., de Wit E. et al.: Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2. bioRxiv, 2020.2004.2015.043166 (2020)
- Wrapp D., Wang N., Corbett K.S., Goldsmith J.A., Hsieh C.-L., Abiona O., Graham B.S., McLellan J.S.: Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation. bioRxiv, 2020.2002.2011.944462 (2020)
- Wujtewicz M., Dylczyk-Sommer A., Aszkiełowicz A., Zdanowski S., Piwowarczyk S., Owczuk R.: COVID-19 – what should anaethesiologists and intensivists know about it? Anaesthesiol. Intensive Ther. 52, 34–41 (2020)
- Xia S., Lu L. et al.: Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 30, 343–355 (2020)
- Xia S., Lu L. et al.: A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci. Adv. 5, eaav4580 (2019)
- Xu J., Zhao S., Teng T., Abdalla A.E., Zhu W., Xie L., Wang Y., Guo X.: Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses, 12, 244 (2020)
- Xu P., Huang J., Fan Z., Huang W., Qi M., Lin X., Song W., Yi L.: Arbidol/IFN-α2b therapy for patients with corona virus disease 2019: a retrospective multicenter cohort study. Microbes Infect. 22, 200–205 (2020)
- Xu X., Wei H. et al.: Effective treatment of severe COVID-19 patients with tocilizumab. Proc. Nat Acad. Sci. USA, 117, 10970 (2020)
- Yamamoto M., Matsuyama S., Li X., Takeda M., Kawaguchi Y., Inoue J.-I., Matsuda Z.: Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay. Antimicrob. Agents Chemother. 60, 6532–6539 (2016)
- Yang Y., Ye F., Zhu N., Wang W., Deng Y., Zhao Z., Tan W.: Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets. Sci. Rep. 5, 17554 (2015)
- Yao X., Liu D. et al.: In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin. Infect. Dis. ciaa237 (2020)
- Yin W., Xu H.E. et al.: Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 1499–1504 (2020)
- Yokota S., Miyamae T., Imagawa T., Iwata N., Katakura S., Mori M., Woo P., Nishimoto N., Yoshizaki K., Kishimoto T.: Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 52, 818–825 (2005)
- Zhang C., Wu Z., Li J.-W., Zhao H., Wang G.-Q.: The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality. Int. J. Antimicrob. Agents, 55, 105954–105954 (2020)
- Zhang P., Wang F. et al.: The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: a case report. BMC Infect. Dis. 20, 317–317 (2020)
- Zhou P., Yang X.-L., Wang X.-G., Hu B., Zhang L., Zhang W., Si H.-R., Zhu Y., Li B., Huang C.-L. et al.: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579, 270–273 (2020)
- Zhou Y., Simmons G. et al.: Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 116, 76–84 (2015)
- Zhu Z., Lu Z., Xu T., Chen C., Yang G., Zha T., Lu J., Xue Y.: Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19. J. Infect. 81, e21–e23 (2020)
- Zinter M.S., Hermiston M.L.: Calming the storm in HLH. Blood, 134, 103–104 (2019)
- Zou Z., Jiang C. et al.: Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat. Commun. 5, 3594–3594 (2014)