Covid-19 – Disease Caused By Sars-Cov-2 Infection – Vaccine And New Therapies Research Development

Nowakowska, Elżbieta; Michalak, Sylwia Sulimiera

doi:10.21307/PM-2020.59.3.16

Abstract

Severe acute respiratory syndrome coronavirus is a new infectious disease caused by a novel coronavirus (SARS-CoV-2). In February 2020 WHO renamed the disease to coronavirus disease 2019 (COVID-19). Coronaviruses belong to the family of Coronaviridae, order Nidovirales. Scientists have visualized the appearance of the SARS-CoV-2 using microscopic techniques, which has a crown-like shape and contains four structural proteins – S, E, M and N. ACE2 (angiotensin converting enzyme 2) is a receptor to which SARS-CoV-2 virus particles bind. The primary test to diagnose infection is the RT-PCR (Real time RT-PCR). Research is underway to identify vaccine against SARS-CoV-2 and therapeutic treatments for COVID-19.

1. Introduction. 2. Epidemiology and pathogenesis of the disease. 3. Molecular structure, division and origin of coronaviruses. 4. Coronavirus binding receptors. 5. Ways of transferring infection. 6. Symptoms and course of infection. 7. Preventive recommendations. 8. Characteristics of tests used to diagnose infections caused by SARS-CoV-2 coronavirus. 9. Studies on a vaccine against SARS-CoV-2 virus. 10. COVID-19 – treatment guidelines – seeking new therapies. 11. Summary

References

Abramczuk E., Pancer K., Gut W., Litwińska B.: Niepandemiczne koronawirusy człowieka – charakterystyka i diagnostyka. Post. Mikrob. 56, 205–213 (2017)
Search in Google Scholar Back to article
Ahmed S.F., Quadeer A.A., McKay M.R.: Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies. Viruses, 12, 254 (2020)
Search in Google Scholar Back to article
Amanat F., Moran T. i wsp.: A serological assay to detect SARS-CoV-2 seroconversion in humans. medRxiv, DOI: 10.1101/2020.03.17.20037717 (2020)
Open DOI Search in Google Scholar Back to article
AOTiM: Zalecenia w COVID-19, 25.04.2020, http://www.aotm.gov.pl/www/wp-content/uploads/covid_19/2020.04.25_zalecenia%20covid19_v1.1.pdf (7.06.2020)
Search in Google Scholar Back to article
Bavishi C., Maddox T.M., Messerli F.H.: Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers. JAMA Cardiol. DOI: 10.1001/jamacardio.2020.1282 (2020)
Open DOI Search in Google Scholar Back to article
Belouzard S., Millet J.K., Licitra B.N., Whittaker G.R.: Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses, 4, 1011–1033 (2012)
Search in Google Scholar Back to article
Chen L., Xiong J., Bao L., Shi Y.: Convalescent plasma as a potential therapy for COVID-19. Lancet Infect. Dis. 20, 398–400 (2020)
Search in Google Scholar Back to article
Chen N., Zhang L. i wsp.: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 395, 507–513 (2020)
Search in Google Scholar Back to article
Chen Y., Peng H., Wang L., Zhao Y., Zeng L., Gao H., Liu Y.: Infants Born to Mothers With a New Coronavirus (COVID-19). Front. Pediatr. DOI: 10.3389/fped.2020.00104 (2020)
Open DOI Search in Google Scholar Back to article
ClinicalTrials.gov: Phase I Clinical Trial of a COVID-19 Vaccine in 18–60 Healthy Adults (CTCOVID-19), 19.05.2020, https://clinicaltrials.gov/ct2/show/NCT04313127 (07.06.2020)
Search in Google Scholar Back to article
Clinical Trials.gov: Use of Ascorbic Acid in Patients With COVID-19, 26.03.2020, https://clinicaltrials.gov/ct2/show/NCT04323514 (08.06.2020)
Search in Google Scholar Back to article
Danielsson N., Catchpole M.: Novel coronavirus associated with severe respiratory disease: Case definition and public health measure. Euro Surveill. DOI: 10.2807/ese.17.39.20282-en (2012)
Open DOI Search in Google Scholar Back to article
Day M.: COVID-19: ibuprofen should not be used for managing symptoms, say doctors and scientists. BMJ, DOI: 10.1136/bmj.m1086 (2020)
Open DOI Search in Google Scholar Back to article
Du L., He Y., Zhou Y., Liu S., Zheng B. J., Jiang S.: The spike protein of SARS-CoV-a target for vaccine and therapeutic development. Nat. Rev. Microbiol. 7, 226–236 (2009)
Search in Google Scholar Back to article
Du L., Li F. i wsp.: Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines. Nat. Commun. 7, 13473 (2016)
Search in Google Scholar Back to article
Eichler H.G., Cavaleri M., Enzmann H., Scotti F., Sepodes B., Sweeney F., Vamvakas S., Rasi G.: Clinical Trials for Covid-19: Can We Better Use the Short Window of Opportunity? Clin. Pharmacol. Ther. DOI: 10.1002/cpt.1891 (2020)
Open DOI Search in Google Scholar Back to article
Etemad B., Whitcomb D.C.: Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology, 120, 682–707 (2001)
Search in Google Scholar Back to article
European Respiratory Society: ACE2 receptor blocers: a novel therapeutic approach for COVID-19, 14.04.2020, https://www.ersnet.org/covid-19-blog/ace2-receptor-blockers-a-novel-the-rapeutic-approach-for-covid-19 (17.05.2020)
Search in Google Scholar Back to article
Fang L., Karakiulakis G., Roth M.: Are Patients With Hypertension and Diabetes Mellitus at Increased Risk for COVID-19 Infection? Lancet Respir. Med. DOI: 10.1016/S2213-2600(20)30116-8 (2020)
Open DOI Search in Google Scholar Back to article
Forbes: What Do Testicles Have To Do With COVID-19 Coronavirus?, 30.04.2020, https://www.forbes.com/sites/brucelee/2020/04/30/what-do-testicles-have-to-do-with-covid-19-coronavirus/#3c4037691690 (17.05.2020)
Search in Google Scholar Back to article
Gautret P., Raoult D. i wsp.: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int. J. Antimicrob. Agents. DOI: 10.1016/j.ijantimicag.2020.105949 (2020)
Open DOI Search in Google Scholar Back to article
GenBank: Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome, 18.03.2020, https://www.ncbi.nlm.nih.gov/nuccore/MN908947.3 (17.05.2020)
Search in Google Scholar Back to article
Gliński Z., Ciołek J.: Nietoperze rezerwuarami i wektorami wirusów chorobotwórczych dla człowieka i zwierząt. Życie Weterynaryjne, 95, 11–16 (2020)
Search in Google Scholar Back to article
Grain J., Flanigan T. i wsp.: Compassionate Use of Remdesivir for Patients with Severe Covid-19. N. Engl. J. Med. 382, 2327–2336 (2020)
Search in Google Scholar Back to article
Guan Y., Poon L.L. i wsp.: Isolation and character ization of viruses related to the SARS coronavirus from animals in southern China. Science, 302, 276–278 (2003)
Search in Google Scholar Back to article
Guan W.J., Zhong N. i wsp.: Clinical Characteristics of Coronavirus Disease 2019 in China. N. Engl. J. Med. 382, 1708–1720 (2020)
Search in Google Scholar Back to article
Guangdi L., De Clercq E.: Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat. Rev. Drug Discovery. 19, 149–150 (2020)
Search in Google Scholar Back to article
Guo Y.R., Cao Q.D., Hong Z.S., Tan Y.Y., Chen S.D., Jin H.J., Tan K.S., Wang D.Y., Yan Y.: The Origin, Transmission and Clinical Therapies on Coronavirus Disease 2019 (COVID-19) Outbreak – An Update on the Status. Mil. Med. Res. DOI: 10.1186/s40779-020-00240-0 (2020)
Open DOI Search in Google Scholar Back to article
Han H.J., Wen H.L., Zhou C.M., Chen F.F., Luo L.M., Liu J.W., Yu X.J.: Bats as reservoirs of severe emerging infectious diseases. Virus Res. 205, 1–6 (2015)
Search in Google Scholar Back to article
Harmer D., Gilbert M., Bormarn R., Clark K.L.: Quantitative mRNA Expression Profiling of ACE 2, a Novel Homologue of Angiotensin Converting Enzyme. FEBS Lett. 532, 107–110 (2002)
Search in Google Scholar Back to article
Harrison C.: Coronavirus puts drug repurposing on the fast track. Nat. Biotechnol. 38, 379–381 (2020)
Search in Google Scholar Back to article
Harvard Health Publishing: Treatments for COVID-19, 24.04. 2020, https://www.health.harvard.edu/diseases-and-conditions/treatments-for-covid-19 (19.05.2020)
Search in Google Scholar Back to article
Hoffmann M., Pöhlmann S. i wsp.: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181, 271–280 (2020)
Search in Google Scholar Back to article
Holshue M.L., Pillai S.K. i wsp.: First Case of 2019 Novel Coronavirus in the United States. N. Engl. J. Med. 382, 929–936 (2020)
Search in Google Scholar Back to article
Horby P.: New data on clinical features, incubation period, and case fatality rate of SARS in Hong Kong and Canada. Euro Surveill. 7, DOI: 10.2807/esw.07.19.02223-en (2003)
Open DOI Search in Google Scholar Back to article
Huang C., Cao B. i wsp.: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395, 497–506 (2020)
Search in Google Scholar Back to article
Imai Y., Penninger J.M. i wsp.: Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature, 436, 112–116 (2005)
Search in Google Scholar Back to article
Kampf G., Todt D., Pfaender S., Steinmann E.: Persistence of coronavirus on inanimate surfaces and their inactivation with biocidal agents, J. Hosp. Infect. 3, 246–251 (2020)
Search in Google Scholar Back to article
Kosobudzki M., Bortkiewicz A.: Genetyczne uwarunkowania chorób układu krążenia. Forum Medycyny Rodzinnej, 6, 1–13 (2012)
Search in Google Scholar Back to article
Kuba K., Penninger J.M. i wsp.: A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nature Medicine, 11, 875–879 (2005)
Search in Google Scholar Back to article
Lai M.M.C., Holmes K.V.: Coronaviridae and their replication (w) In Fields Virology, red. D.M. Knipe, P.M. Howley, Lippincott Williams & Wilkins, Philadelphia, 2001, s. 1163–1185
Search in Google Scholar Back to article
Leung J.M., Yang C.X., Tam A., Shaipanich T., Hackett T.L., Singhera G.K., Dorscheid D.R., Sin D.D.: ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19. Eur. Respir. J. DOI: 10.1183/13993003.00688-2020 (2020)
Open DOI Search in Google Scholar Back to article
Li F.: Structure, Function, and Evolution of Coronavirus Spike Proteins. Annu. Rev. Virol. 3, 237–261 (2016)
Search in Google Scholar Back to article
Liu S., Chan T.C., Chu Y.T., Wu J.T.S., Geng X., Zhao N., Cheng W., Chen E., King C.C.: Comparative epidemiology of human infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among healthcare personnel. PLoS One, DOI: 10.1371/journal.pone.0149988 (2016)
Open DOI Search in Google Scholar Back to article
Liu S., Jiang S. i wsp.: Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. Lancet, 363, 938–947 (2004)
Search in Google Scholar Back to article
Lokugamage K.G., Narayanan K., Nakagawa K., Terasaki K., Ramirez S.I., Tseng C.K., Makino S.: Middle East Respiratory Syndrome Coronavirus nsp1 inhibits host gene expression by selectively targeting mRNAs transcribed in the nucleus while sparing mRNAs of cytoplasmic origin. J. Virol. 89, 10970–10981 (2015)
Search in Google Scholar Back to article
Lu L., Jiang S. i wsp.: Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat. Commun. 5, 3067 (2014)
Search in Google Scholar Back to article
Lui P.Y., Wong L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y., Jin D.Y.: Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3. Emerging Microbes Infect. 5, 1–9 (2016)
Search in Google Scholar Back to article
Lundin A., Trybala E. i wsp.: Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the Middle East respiratory syndrome virus. PLoS Pathog. DOI: 10.1371/journal.ppat.1004166 (2014)
Open DOI Search in Google Scholar Back to article
Ma L., Xie W., Li D., Shi L., Mao Y., Xiong Y., Zhang Y., Zhang M.: Effect of SARS-CoV-2 infection upon male gonadal function: A single center-based study. medRxiv, DOI: 10.1101/2020.03.21.20037267 (2020)
Open DOI Search in Google Scholar Back to article
Mahase E.: Covid-19: what do we know so far about a vaccine? BMJ, DOI: 10.1136/bmj.m1679 (2020)
Open DOI Search in Google Scholar Back to article
Marczyńska M.: Zalecenia terapeutyczne dla dzieci zakażonych HIV. HIV & AIDS Review, 12, 116–118 (2013)
Search in Google Scholar Back to article
Medicover: Sposoby walki z COVID-19 – leki, osocze rekonwalescencyjne, a może szczepionka?, 19.05.2020, https://www.medicover.pl/o-zdrowiu/sposoby-walki-z-covid-19-lekiosocze-rekonwalescencyjne-a-moze-szczepionka,6916,n,192 (21.05.2020)
Search in Google Scholar Back to article
Międzynarodowa Federacja Farmaceutyczna: COVID-19: Informacje kliniczne i wytyczne dotyczące leczenia, 26.03.2020, https://www.nia.org.pl/wp-content/uploads/2020/04/FIP-Przewodnik-COVID-19-PL-002.pdf (18.05.2020)
Search in Google Scholar Back to article
Mousavizadeh L., Ghasemi S.: Genotype and phenotype of COVID-19: Their roles in pathogenesis. Journal of Microbiology, Immunology and Infection, DOI: 10.1016/j.jmii.2020.03.022 (2020)
Open DOI Search in Google Scholar Back to article
Mrukowicz J., Ściubisz M.: Wyścig po szczepionkę przeciwko SARS-CoV-2. Wielkie nadzieje i wielkie znaki zapytania. Med. Prakt. 5, 36–48 (2020)
Search in Google Scholar Back to article
Nejm Journal Watch: Lack of Efficacy of Hydroxychloroquine or Azithromycin on COVID-19 Clinical Course, https://www.jwatch.org/na51549/2020/05/13/lack-efficacy-hydroxychloroquine-or-azithromycin-covid-19 (07.06.2020)
Search in Google Scholar Back to article
Nextstrain: Phylogeny of SARS-like betacoronaviruses including novel coronavirus from Wuhan using data generated by the Shanghai Public Health Clinical Center & School of Public Health, the National Institute for Viral Disease Control and Prevention, the Institute of Pathogen Biology, and the Wuhan Institute of Virology shared via GISAID, 26.02.2020, https://nextstrain.org/groups/blab/sars-like-cov (17.05.2020)
Search in Google Scholar Back to article
Puls Medycyny: Leki na koronawirusa SZAR-CoV-2: skuteczne mogą być już znane substancje, 23.03.2020, https://pulsmedycyny.pl/leki-na-koronawirusa-sars-cov-2-skuteczne-moga-bycjuz-znane-substancje-984865 (09.06.2020)
Search in Google Scholar Back to article
Pyrć K.: Ludzkie koronawirusy. Post. Nauk Med. 28, 48–54 (2015)
Search in Google Scholar Back to article
Qin N., Kaijin X. i wsp.: Retrospective study of low-to-moderate dose glucocorticoids on viral clearance in patients with novel coronavirus pneumonia. Chinese Journal of Clinical Infectious Diseases, DOI: 10.3760/cma.j.cn115673-20200225-00072 (2020)
Open DOI Search in Google Scholar Back to article
Rastawicki W., Rokosz-Chudziak N.: Charakterystyka oraz ocena przydatności serologicznych testów w diagnostyce zakażeń wywołanych przez koronawirus SARS-CoV-2 na podstawie dostępnych danych producentów i przeglądu piśmiennictwa. Przegl. Epidemiol. 74, 113–132 (2020)
Search in Google Scholar Back to article
Reuters: Poland reports first coronavirus case – health minister, 4.03.2020, https://www.reuters.com/article/us-health-coronavirus-poland/poland-reports-first-coronavirus-case-health-minister-idUSKBN20R0U7 (05.06.2020)
Search in Google Scholar Back to article
Rut W., Groborz K., Zhang L., Sun X., Zmudzinski M., Hilgenfeld R., Drag M.: Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design. bioRxiv, DOI: 10.1101/2020.03.07.981928 (2020)
Open DOI Search in Google Scholar Back to article
Sama I.E., Voors A.A. i wsp.: Circulating Plasma Concentrations of Angiotensin-Converting Enzyme 2 in Men and Women With Heart Failure and Effects of Renin-Angiotensin-Aldosterone Inhibitors. Eur. Heart J. 41, 1810–1817 (2020)
Search in Google Scholar Back to article
Sanders J.M., Monogue M.L., Jodlowski T.Z., Cutrell J.B.: Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19). A Review. JAMA, 323, 1824–1836 (2020)
Search in Google Scholar Back to article
Sheahan T.P., Baric R.S. i wsp.: Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci. Transl. Med. DOI: 10.1126/scitranslmed.aal3653 (2017)
Open DOI Search in Google Scholar Back to article
Sheahan T.P., Baric R.S. i wsp.: Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat. Commun. DOI: 10.1038/s41467-019-13940-6
Open DOI Search in Google Scholar Back to article
Soro-Paavonen A., Gordin D., Forsblom C., Rosengard-Barlund M., Waden J., Thorn L., Sandholm N., Thomas M.C., Groop P.H., FinnDiane Study Group.: Circulating ACE2 Activity Is Increased in Patients With Type 1 Diabetes and Vascular Complications. J. Hypertens. 30, 375–383 (2012)
Search in Google Scholar Back to article
Stilhano R.S., Costa A.J., Nishino M.A., Shams S., Bartolomeo C.S., Breithaupt-Faloppa A.C., Silva E.A., Ramirez A.L., Prado C.M., Ureshino R.P.: SARS-CoV-2 and the Possible Connection to ERs, ACE2 and RAGE: Focus on Susceptibility Factors. Preprints, DOI: 10.20944/preprints202005.0178.v1 (2020)
Open DOI Search in Google Scholar Back to article
Tang X., Lu J. i wsp.: On the orgin and continuing evolution of SARS-CoV-2. Natl. Sci. Rev. 7, 1012–1023 (2020)
Search in Google Scholar Back to article
Tu C., Wang L.F. i wsp.: Antibodies to SARS coro navirus in civets. Emerging Infect. Dis. 10, 2244–2248 (2004)
Search in Google Scholar Back to article
Vabret A., Dina J., Brison E., Brouard J., Freymuth F.: Human coronaviruses. Pathol. Biol. (Paris) 57, 149–160 (2009)
Search in Google Scholar Back to article
van der Hoek L., Pyrć K., Berkhout B.: Human coronavirus NL63, a new respiratory virus. FEMS Microbiol. Rev. 30, 760–773 (2006)
Search in Google Scholar Back to article
van Doremalen N., Munster V.J. i wsp.: Aerosol and Surface Stability of SARS-CoV-2 as Compared With SARS-Cov-1. N. Engl. J. Med. 382, 1564–1567 (2020)
Search in Google Scholar Back to article
Vashist S.K.: In Vitro Diagnostic Assays for COVID-19: Recent Advances and Emerging Trends. Diagnostics, DOI: 10.3390/disgnostics10040202 (2020)
Open DOI Search in Google Scholar Back to article
Vijaykrishna D., Smith G.J.D., Zhang J.X., Peiris J.S.M., Chen H., Guan Y.: Evolutionary insights into the ecology of coronaviruses. J. Virol. 81, 4012–4020 (2007)
Search in Google Scholar Back to article
Villar J., Gonzales-Martin J.M. i wsp.: Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Lancet Respir. Med. 8, 267–276 (2020)
Search in Google Scholar Back to article
Waliszewski K., Słomski R., Jura J., Oszkinis G., Gabriel M., Strauss E., Pawlak A.: Zmiany częstości alleli i rozkładu genotypów genu ACE w populacji chorych na tętniaka aorty brzusznej. J. Med. Sci. 12, 169–175 (2003)
Search in Google Scholar Back to article
Wang M., Cao R., Zhang L., Yang X., Liu J., Xu M., Shi Z., Hu Z., Zhong W., Xiao G.: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30, 269–271 (2020)
Search in Google Scholar Back to article
Wang N., Shang J., Jiang S., Du L.: Subunit Vaccines Against Emering Pathogenic Human Coronaviruses. Front. Mikrobiol. DOI: 10.3389/fmicb.2020.00298 (2020)
Open DOI Search in Google Scholar Back to article
Wang Q., Wong G., Lu G., Yan J., Gao G.F.L.: MERS-CoV spike protein: targets for vaccines and therapeutics. Antiviral Res. 133, 165–177 (2016)
Search in Google Scholar Back to article
World Health Organization: Coronavirus diseae (COVID-19) Pandemic, https://www.who.int/emergencies/diseases/novel-coronavirus-2019 (16.05.2020)
Search in Google Scholar Back to article
World Health Organization: Director-General’s opening remarks at the media briefing on COVID-19, 11.03.2020, https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19--11-march-2020 (16.05.2020)
Search in Google Scholar Back to article
World Health Organization: Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases, 2.03.2020, https://apps.who.int/iris/bitstream/handle/10665/331329/WHO-COVID-19-laboratory-2020.4-eng.pdf?sequence=1&i-sAllowed=y, (17.05.2020)
Search in Google Scholar Back to article
World Health Organization: Middle East respiratory syndrome coronavirus (MERS-CoV). Summary of current situation, literature update and risk assessment. 07.07.2015, http://apps.who.int/iris/bitstream/10665/179184/2/WHO_MERS_RA_15.1_eng.pdf (16.05.2020)
Search in Google Scholar Back to article
World Health Organization: Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003, 31.12.2003, https://www.who.int/csr/sars/country/table2004_04_21/en// (16.05.2020)
Search in Google Scholar Back to article
Worldometer: COVID-19 Coronavirus pandemic, 19.05.2020, https://www.worldometers.info/coronavirus (20.05.2020)
Search in Google Scholar Back to article
Wu D., Yang X.O.: TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib. J. Microbiol. Immunol. Infect. 53, 368–370 (2020)
Search in Google Scholar Back to article
Wysocki J., Gonzales-Pacheco F.R., Battle D.: Angiotensin-converting enzyme 2: Possible role in hypertension and kidney disease. Current Hypertension Reports, 10, 70–77 (2008)
Search in Google Scholar Back to article
Xiao F., Hiremath S., Knoll G., Zimpelmann J., Srivaratharajah K., Jadhav D., Fergusson D., Kennedy C.R., Burns K.D.: Increased urinary angiotensin-converting enzyme 2 in renal transplant patients with diabetes. PLoS One, DOI: 10.1371/journal.pone.0037649 (2012)
Open DOI Search in Google Scholar Back to article
Xiao F., Tang M., Zheng X., Liu Y., Li X., Shan H.: Evidence for gastrointensinal infection of SARS-CoV-2. Gastroenterology, 158, 1831–1833 (2020)
Search in Google Scholar Back to article
Xinhuanet: New-type coronavirus causes pneumonia in Wuhan: expert, 09.01.2020, http://www.xinhuanet.com/english/2020-01/09/c_138690570.htm (16.05.2020)
Search in Google Scholar Back to article
Zhang H., Li H.B., Lyu J.R., Lei X.M., Li W., Wu G., Lyu J., Dai Z.M.: Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. Int. J. Infect. Dis. 96, 19–24 (2020)
Search in Google Scholar Back to article
Zhou P., Shi Z.L. i wsp.: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579, 270–273 (2020)
Search in Google Scholar Back to article
Zhu N., Tan W. i wsp.: A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727–733 (2020)
Search in Google Scholar Back to article

Covid-19 – Disease Caused By Sars-Cov-2 Infection – Vaccine And New Therapies Research Development

Abstract

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