ANTIMICROBIAL ACTIVITY OF LIPOPEPTIDES

Czechowicz, Paulina; Nowicka, Joanna

doi:10.21307/PM-2018.57.3.213

Abstract

The constantly growing number of multidrug-resistant bacterial strains prompts the search for alternative treatments. Synthetic peptides based on natural antimicrobial peptides, also known as antimicrobial lipopeptides, can become a promising group of “drugs” to fight multi-resistant bacteria. The present paper discusses the origins of synthetic lipopeptides, their classification and antimicrobial properties.

1. Introduction. 2. Antimicrobial peptides. 3. Classification of antimicrobial peptides. 4. Lipopeptide antibiotics. 5. Synthetic lipopeptides. 5.1. Ultrashort lipopeptides. 5.2. Peptidomimetics. 5.3. Multivalent lipopeptides. 5.4. Hydrocarbon-stapled lipopeptides. 5.5. Antimicrobial lipopeptides in laboratory researches. 6. Summary

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ANTIMICROBIAL ACTIVITY OF LIPOPEPTIDES

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