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Ultrasound imaging in floppy eyelid syndrome: anatomical and clinical considerations Cover

Ultrasound imaging in floppy eyelid syndrome: anatomical and clinical considerations

Open Access
|Jun 2025

References

  1. Culbertson WW, Ostler HB: The floppy eyelid syndrome. Am J Ophthalmol 1981; 92: 568–575. doi: 10.1016/0002-9394(81)90652-8.
  2. Salinas R, Puig M, Fry CL, Johnson DA, Kheirkhah A: Floppy eyelid syndrome: A comprehensive review. Ocul Surf 2020; 18: 31–39. doi: 10.1016/j.jtos.2019.10.002.
  3. Goldberg R, Seiff S, McFarland J, Simons K, Shorr N: Floppy eyelid syndrome and blepharochalasis. Am J Ophthalmol 1986; 102: 376–381. doi: 10.1016/0002-9394(86)90014-0.
  4. Netland PA, Sugrue SP, Albert DM, Shore JW.: Histopathologic features of the floppy eyelid syndrome. Involvement of tarsal elastin. Ophthalmology 1994; 101: 174–181. doi: 10.1016/s0161-6420(94)31368-6.
  5. Huon LK, Liu SY, Camacho M, Guilleminault C: The association between ophthalmologic diseases and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Breath 2016; 20: 1145–1154. doi: 10.1007/s11325-016-1358-4.
  6. De Gregorio A, Cerini A, Scala A, Lambiase A, Pedrotti E, Morselli S: Floppy eyelid, an under-diagnosed syndrome: a review of demographics, pathogenesis, and treatment. Ther Adv Ophthalmol 2021; 13: 25158414211059247. doi: 10.1177/25158414211059247.
  7. Levy J, Barrett DL, Harris N, Jeong JJ, Yang X, Chen SC: High-frequency ultrasound in clinical dermatology: a review. Ultrasound J 2021; 13: 24. doi: 10.1186/s13089-021-00222-w.
  8. Detorakis ET, Drakonaki EE, Tsilimbaris MK, Pallikaris IG, Giarmenitis S: Real-time ultrasound elastographic imaging of ocular and periocular tissues: a feasibility study. Ophthalmic Surg Lasers Imaging 2010; 41: 135–141. doi: 10.3928/15428877-20091230-24.
  9. Bontzos G, Douglas VP, Douglas KAA, Kapsala Z, Drakonaki EE, Detorakis ET: Ultrasound elastography in ocular and periocular tissues: a review. Curr Med Imaging 2021; 17: 1041–1053. doi: 10.2174/1573405616666201214123117.
  10. Douglas KA, Drakonaki EE, Douglas VP, Detorakis ET: Shear-wave elastographic imaging in choroidal melanomas: clinical and hemodynamic correlations. Jpn J Ophthalmol 2024; 68: 523–530. doi: 10.1007/s10384-024-01086-y.
  11. Sigrist RMS, Liau J, Kaffas AE, Chammas MC, Willmann JK: Ultrasound elastography: review of techniques and clinical applications. Theranostics 2017; 7: 1303–1329. doi: 10.7150/thno.18650.
  12. Meng Y, Feng L, Shan J, Yuan Z, Jin L: Application of high-frequency ultrasound to assess facial skin thickness in association with gender, age, and BMI in healthy adults. BMC Med Imaging 2022; 22: 113. doi: 10.1186/s12880-022-00839-w.
  13. Shu CC, Lee P, Lin JW, Huang CT, Chang YC, Yu CJ, Wang HC: The use of sub-mental ultrasonography for identifying patients with severe obstructive sleep apnea. PLoS One 2013; 8: e62848. doi: 10.1371/journal.pone.0062848.
  14. Coquia SF, Hamper UM, Holman ME, DeJong MR, Subramaniam RM, Aygun N, Fakhry C: Visualization of the oropharynx with transcervical ultrasound. AJR Am J Roentgenol 2015; 205: 1288–1294. doi: 10.2214/AJR.15.14299.
  15. Beis PG, Brozou CG, Gourgoulianis KI, Pastaka C, Chatzoulis DZ, Tsironi EE: The floppy eyelid syndrome: evaluating lid laxity and its correlation to sleep apnea syndrome and body mass index. ISRN Ophthalmol 2012; 2012: 650892. doi: 10.5402/2012/650892.
  16. Chen G, Leng X, Liu W, Meng J, Liao X: High-frequency ultrasound findings of sebaceous carcinoma in the eyelid. Skin Res Technol 2024; 30: e13555. doi: 10.1111/srt.13555.
  17. Santos R, Valamatos MJ, Mil-Homens P, Armada-da-Silva PAS: Effect of Knee Angle, Contractile Activity, and Intensity of Force Production on Vastus Lateralis Stiffness: A Supersonic Shear Wave Elastography Pilot Study. Sports (Basel) 2024; 12: 211. doi: 10.3390/sports12080211.
  18. Xu R, Ren L, Zhang X, Qian Z, Wu J, Liu J, Li Y, Ren L: Non-invasive in vivo study of morphology and mechanical properties of the median nerve. Front Bioeng Biotechnol 2024; 12: 1329960. doi: 10.3389/fbioe.2024.1329960.
  19. McCormack B, Hampton HL, Speich JE, Radley SC, Burkett LS, Klausner AP: Ultrasound urodynamics: a review of ultrasound imaging techniques for enhanced bladder functional diagnostics. Curr Bladder Dysfunct Rep 2024; 19: 263–271. doi: 10.1007/s11884-024-00758-2.
  20. Skrip LM, Moosburner S, Tang P, Guo J, Görner S, Tzschätzsch H, et al.: Viscoelastic properties of colorectal liver metastases reflect tumour cell viability. J Transl Med 2024; 22: 774. doi: 10.1186/s12967-024-05559-z.
  21. Ma S, Zhang Z, Li GY, Cao Y: Guided wave elastography of human skins with a layered model incorporating the effect of muscle state. J Biomech 2024; 174: 112279. doi: 10.1016/j.jbiomech.2024.112279.
  22. Netland PA, Sugrue SP, Albert DM, Shore JW: Histopathologic features of the floppy eyelid syndrome. Involvement of tarsal elastin. Ophthalmology 1994; 101: 174–181. doi: 10.1016/s0161-6420(94)31368-6.
  23. Klapper SR, Jordan DR. Floppy eyelid syndrome. Ophthalmology 1998; 105: 1582. doi: 10.1016/S0161-6420(98)99017-0
  24. Naya Y, Takanari H: Elastin is responsible for the rigidity of the ligament under shear and rotational stress: a mathematical simulation study. J Orthop Surg Res 2023; 18: 310. doi: 10.1186/s13018-023-03794-6.
  25. Beis PG, Brozou CG, Gourgoulianis KI, Pastaka C, Chatzoulis DZ, Tsironi EE: The floppy eyelid syndrome: evaluating lid laxity and its correlation to sleep apnea syndrome and body mass index. ISRN Ophthalmol 2012; 2012:650892. doi: 10.5402/2012/650892.
  26. Paciuc M, Mier ME: A woman with the floppy eyelid syndrome. Am J Ophthalmol 1982; 93: 255–256. doi: 10.1016/0002-9394(82)90429-9.
  27. Gross RH, Mannis MJ: Floppy eyelid syndrome in a child with chronic unilateral conjunctivitis. Am J Ophthalmol 1997; 124: 109–110. doi: 10.1016/s0002-9394(14)71654-x.
  28. Ezra DG, Beaconsfield M, Sira M, Bunce C, Wormald R, Collin R: The associations of floppy eyelid syndrome: a case control study. Ophthalmology 2010; 117: 831–838. doi: 10.1016/j.ophtha.2009.09.029.
  29. Kloosterboer A, Negron CY, Stokkermans TJ: Floppy eyelid syndrome. (Updated 2023 Apr 19). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–.
  30. Cahali MB, Soares CF, Dantas DA, Formigoni GG: Tonsil volume, tonsil grade and obstructive sleep apnea: is there any meaningful correlation? Clinics (Sao Paulo). 2011; 66: 1347–1352. doi: 10.1590/s1807-59322011000800007.
DOI: https://doi.org/10.15557/jou.2025.0019 | Journal eISSN: 2451-070X | Journal ISSN: 2084-8404
Language: English
Submitted on: Mar 16, 2025
Accepted on: Jun 10, 2025
Published on: Jun 30, 2025
Published by: MEDICAL COMMUNICATIONS Sp. z o.o.
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Vasilios Batis, Efstathios Detorakis, Sophia Schiza, Emmanuel Prokopakis, Konstantinos Krasagakis, Elena Drakonaki, published by MEDICAL COMMUNICATIONS Sp. z o.o.
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.