Summary of histopathological and ultrasound features of different intrinsic subtypes of breast cancer
| Intrinsic subtype | Main histopathological features(9) | Main ultrasound features(4) |
|---|---|---|
| Luminal A | MA: poorly demarcated tumor of soft texture, 25% multifocal (ILC) MI: diffuse-infiltrative growth without focal findings | Hyperechogenic halo, spiculae |
| Luminal B (incl. “HER-2 enriched”) | MA: knotty, of firm consistency and has radial spurs MI: polygonal, cohesive tumor cells, infiltrating-destructive growth | Increased vascularity, lack of halo |
| HER-2 positive* | MA: locally restricted, multifocal MI: presence of DCIS | Calcifications, multifocality |
| TNBC | MA: Well-defined tumor with soft texture, focal necrosis, or hemorrhage within the tumor MI: syncytial architecture | Lobular margins, acoustic enhancements |