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Mixture and Non-Mixture Cure Fraction Models Based on Generalized Gompertz Distribution under Bayesian Approach Cover

Mixture and Non-Mixture Cure Fraction Models Based on Generalized Gompertz Distribution under Bayesian Approach

Open Access
|Jan 2017

Abstract

The cure fraction models are generally used to model lifetime data with long term survivors. In a cohort of cancer patients, it has been observed that due to the development of new drugs some patients are cured permanently, and some are not cured. The patients who are cured permanently are called cured or long term survivors while patients who experience the recurrence of the disease are termed as susceptibles or uncured. Thus, the population is divided into two groups: a group of cured individuals and a group of susceptible individuals. The proportion of cured individuals after the treatment is typically known as the cure fraction. In this paper, we have introduced a three parameter Gompertz (viz. scale, shape and acceleration) or generalized Gompertz distribution in the presence of cure fraction, censored data and covariates for estimating the proportion of cure fraction through Bayesian Approach. Inferences are obtained using the standard Markov Chain Monte Carlo technique in openBUGS software.

DOI: https://doi.org/10.1515/tmmp-2016-0025 | Journal eISSN: 1338-9750 | Journal ISSN: 12103195
Language: English
Page range: 121 - 135
Submitted on: Aug 23, 2016
Published on: Jan 20, 2017
Published by: Slovak Academy of Sciences, Mathematical Institute
In partnership with: Paradigm Publishing Services
Publication frequency: 3 issues per year

© 2017 Prafulla Kumar Swain, Gurprit Grover, Komal Goel, published by Slovak Academy of Sciences, Mathematical Institute
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.