Is 3 Weeks of Exercise Enough to Change Blood Pressure and Cardiac Redox State in Hypertensive Rats? Cover

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Is 3 Weeks of Exercise Enough to Change Blood Pressure and Cardiac Redox State in Hypertensive Rats?

EABR. Experimental and Applied Biomedical Research

Volume 20 (2019): Issue 4 (December 2019)

By: Biljana Jakovljevic, Sasa Plecevic, Anica Petkovic, Tamara Nikolic Turnic, Isidora Milosavljevic, Kristina Radoman and Ivan Srejovic

Open Access

|Dec 2019

Figures & Tables

Mean body weight of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. * statistical significance between S-HTA-3 vs S-NTA-3; # statistical significance between HTA-3 vs NTA-3.

Effects of 3 weeks of swimming on TBARS levels of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. *statistical significance at the level of p < 0.05 is shown in Table 2.

Effects of 3 weeks of swimming on NO2− levels of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. *statistical significance at the level of p < 0.05 is shown in Table 2.

Effects of 3 weeks of swimming on O2− levels of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. *statistical significance at the level of p < 0.05 is shown in Table 2.

Effects of 3 week of swimming on H2O2 levels of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. *statistical significance at the level of p < 0.05 is shown in Table 2.

The average values of hemodynamic parameters of hypertensive and normotensive rats that swam for three weeks and their controls in last week

Groups	Hemodynamic parameters
Groups	SBP (mmHg)	DBP (mmHg)	MAP (mmHg)	HR (bpm)
S-HTA-3	196,37 ± 6,87 ^a,b	104,31 ± 7,12 ^a,b	137,68 ± 6,64 ^a,b	330,19 ± 19,27
HTA-3	205,69 ± 7,19	115,81 ± 8,73	142,23 ± 7,12	325,17 ± 14,37
S-NTA-3	120,01 ± 4,27	80,18 ± 6,45	92,03 ± 6,75	339,28 ± 17,21
NTA-3	123,98 ± 6,15	83,23 ± 7,65	96,13 ± 4,27	327,48 ± 16,57

Significance in level of oxidative stress parameters between hypertensive and normotensive rats who swam for three weeks at different values of coronary perfusion pressures

CPP (cmH₂O)	O₂⁻ (nmol/min/g wt)				NO (nmol/min/g wt)
	S-HTA-3 vs. HTA-3	S-NTA-3 vs. NTA-3	S-HTA-3 vs. S-NTA-3	HTA-3 vs. NTA-3	S-HTA-3 vs. HTA-3	S-NTA-3 vs. NTA-3	S-HTA-3 vs. S-NTA-3	HTA-3 vs. NTA-3
40	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
60	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
80	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
100	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
120	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
	H₂O₂ (nmol/min/g wt)				TBARS (μmol/min/g wt)
	S-HTA-3 vs. HTA-3	S-NTA-3 vs. NTA-3	S-HTA-3 vs. S-NTA-3	HTA-3 vs. NTA-3	S-HTA-3 vs. HTA-3	S-NTA-3 vs. NTA-3	S-HTA-3 vs. S-NTA-3	HTA-3 vs. NTA-3
40	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
60	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
80	p>0,050	p>0,050	p=0,049	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
100	p>0,050	p>0,050	p=0,037	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050
120	p>0,050	p>0,050	p=0,029	p>0,050	p>0,050	p>0,050	p>0,050	p>0,050

DOI: https://doi.org/10.1515/sjecr-2017-0049 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454

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Language: English

Page range: 319 - 326

Submitted on: Sep 20, 2017

Accepted on: Sep 26, 2017

Published on: Dec 31, 2019

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

oxidative stress,

Related subjects:

Clinical medicine,

Clinical medicine, other

© 2019 Biljana Jakovljevic, Sasa Plecevic, Anica Petkovic, Tamara Nikolic Turnic, Isidora Milosavljevic, Kristina Radoman, Ivan Srejovic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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