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Is 3 Weeks of Exercise Enough to Change Blood Pressure and Cardiac Redox State in Hypertensive Rats? Cover

Is 3 Weeks of Exercise Enough to Change Blood Pressure and Cardiac Redox State in Hypertensive Rats?

EABR. Experimental and Applied Biomedical Research
Volume 20 (2019): Issue 4 (December 2019)
By: ,  ,  ,  ,  ,   and    
Open Access
|Dec 2019
Figures & tables

Figures & Tables

Fig. 1

Mean body weight of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. * statistical significance between S-HTA-3 vs S-NTA-3; # statistical significance between HTA-3 vs NTA-3.

Table 1

The average values of hemodynamic parameters of hypertensive and normotensive rats that swam for three weeks and their controls in last week

GroupsHemodynamic parameters
SBP (mmHg)DBP (mmHg)MAP (mmHg)HR (bpm)
S-HTA-3196,37 ± 6,87 a,b104,31 ± 7,12 a,b137,68 ± 6,64 a,b330,19 ± 19,27
HTA-3205,69 ± 7,19115,81 ± 8,73142,23 ± 7,12325,17 ± 14,37
S-NTA-3120,01 ± 4,2780,18 ± 6,4592,03 ± 6,75339,28 ± 17,21
NTA-3123,98 ± 6,1583,23 ± 7,6596,13 ± 4,27327,48 ± 16,57

Data are means ± SD. SBP, systolic pressure; DBP, diastolic pressure; MAP, mean arterial pressure; HR, heart rate. Statistical significance was considered for a p value less than 0.05 (*p<0.05);

a p < 0.05- S-HTA-3 vs. HTA-3;

b p < 0.05- S-HTA-3 vs. S-NTA-3; S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats.

Fig. 2

Effects of 3 weeks of swimming on TBARS levels of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. *statistical significance at the level of p < 0.05 is shown in Table 2.

Fig. 3

Effects of 3 weeks of swimming on NO2− levels of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. *statistical significance at the level of p < 0.05 is shown in Table 2.

Fig. 4

Effects of 3 weeks of swimming on O2− levels of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. *statistical significance at the level of p < 0.05 is shown in Table 2.

Fig. 5

Effects of 3 week of swimming on H2O2 levels of hypertensive and normotensive rats. The values are represented as mean ± SD. S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats. *statistical significance at the level of p < 0.05 is shown in Table 2.

Table 2

Significance in level of oxidative stress parameters between hypertensive and normotensive rats who swam for three weeks at different values of coronary perfusion pressures

CPP (cmH2O)O2− (nmol/min/g wt)NO (nmol/min/g wt)
S-HTA-3 vs. HTA-3S-NTA-3 vs. NTA-3S-HTA-3 vs. S-NTA-3HTA-3 vs. NTA-3S-HTA-3 vs. HTA-3S-NTA-3 vs. NTA-3S-HTA-3 vs. S-NTA-3HTA-3 vs. NTA-3
40p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050
60p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050
80p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050
100p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050
120p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050
H2O2 (nmol/min/g wt)TBARS (μmol/min/g wt)
S-HTA-3 vs. HTA-3S-NTA-3 vs. NTA-3S-HTA-3 vs. S-NTA-3HTA-3 vs. NTA-3S-HTA-3 vs. HTA-3S-NTA-3 vs. NTA-3S-HTA-3 vs. S-NTA-3HTA-3 vs. NTA-3
40p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050
60p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050p>0,050
80p>0,050p>0,050p=0,049p>0,050p>0,050p>0,050p>0,050p>0,050
100p>0,050p>0,050p=0,037p>0,050p>0,050p>0,050p>0,050p>0,050
120p>0,050p>0,050p=0,029p>0,050p>0,050p>0,050p>0,050p>0,050

[i] S-HTA-3-hypertensive rats that swam for 3 weeks; HTA-3-sedentery hypertensive control rats; S-NTA-3-normotensive rats that swam for 3 weeks; NTA-3-sedentery normotensive control rats.

DOI: https://doi.org/10.1515/sjecr-2017-0049 | Journal eISSN: 2956-2090 (formerly 2335-075X, 2956-0454) | Journal ISSN: 2956-0454 (formerly 1820-8665)
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Language: English
Page range: 319 - 326
Submitted on: Sep 20, 2017
Accepted on: Sep 26, 2017
Published on: Dec 31, 2019
Published by: University of Kragujevac, Faculty of Medical Sciences
In partnership with: Paradigm Publishing Services
Keywords:
hypertension,
oxidative stress,
swimming,
rat heart
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other

© 2019 Biljana Jakovljevic, Sasa Plecevic, Anica Petkovic, Tamara Nikolic Turnic, Isidora Milosavljevic, Kristina Radoman, Ivan Srejovic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 20 (2019): Issue 4 (December 2019)
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