Expression Of The Bcl2 Gene In Chronic Lymphocytic Leukaemia Patients

Ksenija Vucicevic; Vladimir Jakovljevic; Jasmina Sretenovic; Natasa Tosic; Tatjana Kostic; Irena Glumac; Milica Colovic; Natasa Colovic; Sonja Pavlovic; Teodora Karan-Djurasevic

doi:10.1515/sjecr-2015-0024

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Expression Of The Bcl2 Gene In Chronic Lymphocytic Leukaemia Patients

EABR. Experimental and Applied Biomedical Research

Volume 16 (2015): Issue 3 (September 2015)

By: Ksenija Vucicevic, Vladimir Jakovljevic, Jasmina Sretenovic, Natasa Tosic, Tatjana Kostic, Irena Glumac, Milica Colovic, Natasa Colovic, Sonja Pavlovic and Teodora Karan-Djurasevic

Open Access

|Oct 2015

Abstract

Chronic lymphocytic leukaemia (CLL) manifests as clonal expansion of mature B lymphocytes, whose accumulation is primarily attributed to the dysregulation of apoptosis. Aberrant expression, as well as genetic alterations within various Bcl2 family members and central regulators of the intrinsic, mitochondria-mediated apoptotic pathway all hasve been observed in CLL. Here, we report the expression analysis of the anti-apoptotic Bcl2 gene in a cohort of 58 CLL patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) analysis revealed a significant overexpression of Bcl2 mRNA in CLL samples compared to control samples (p=<0.001). Receiver operating characteristic (ROC) analysis showed that the level of Bcl2 expression exerts a high discriminatory power between patients and healthy subjects (A=0.98, 95% CI=0.95-1.009, p<0.0001).

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Articles in this issue

DOI: https://doi.org/10.1515/sjecr-2015-0024 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454

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Language: English

Page range: 187 - 191

Submitted on: Dec 25, 2014

Accepted on: Feb 20, 2015

Published on: Oct 14, 2015

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

Chronic lymphocytic leukaemia,

Bcl2,

Related subjects:

Clinical medicine, other

© 2015 Ksenija Vucicevic, Vladimir Jakovljevic, Jasmina Sretenovic, Natasa Tosic, Tatjana Kostic, Irena Glumac, Milica Colovic, Natasa Colovic, Sonja Pavlovic, Teodora Karan-Djurasevic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 16 (2015): Issue 3 (September 2015)