Figure 1
MR images showing interobserver variability between an unexperienced RO and the reference contour in IGABT of 4 cervix cancer patients (from a workshop for RO residents at the Institute of Oncology Ljubljana).
Figure 2
Interobserver variability in delineation of the prostate. MR and CT images in different planes of the same patient are shown. Ability to discriminate prostate apex, base and lateral borders is superior on MRI.
cor = coronal; sag = sagittal; tra = transverse40
Table 1
Interobserver variation for various tumour sites
| Tumoursite | Target volume | No of pts | No of obs | Imaging modality | Results | Author (publication date) |
|---|---|---|---|---|---|---|
| Rectum | GTV, CTV | 2 | 10 | CT, PETCT | CI(GTV) = 0.26-0.33 CI(CTV) = 0.29-0.35 | Krengli et al 2010 |
| GTV | 52 | 5 | CT, PETCT, MRI | CI = 0.79-0.93 | Bujisen et al 2012 | |
| CTV | 8 | 10 | CT | CI = 0.63-0.66 | Nijkamp et al 2012 | |
| GTV | 6 | 4 | CT, PETCT | SI(GTV-P) = 0.77-0.81 SI(GTV-N) = 0.22-0.70 | Patel et al 2007 | |
| Stomach | CTV, PTV | 1 | 10 | CT | Vmax/Vmin(CTV) = 3.4 Vmax/Vmin(PTV) = 2.6 | Jansen et al 2010 |
| Oesophagus | GTV | 1 | 50 | CT | JCI = 0.69 | Gwynne et al 2012 |
| GTV, CTV, PTV | 1 | 48 | CT | Vmax/Vmin(PTV) = 5.25-6.03 | Tai et al 1998 | |
| Cervix EBRT | CTV | 3 | 7 | CT | CI = 0.11-0.57 Vmax/Vmin = 3.6-4.9 | Weiss et al 2003 |
| IGABT | GTV, HRCTV, IRCTV | 6 | 10 | MRI | CI(GTV) = 0.6-0.8 CI(HR&IRCTV) = 0.6-0.7 | Petrič et al 2012, 2013 |
| Head and neck | GTV, CTV, PTV | 1 | 20 | CT | Vmax/Vmin(CTV) = 18.3 | Hong et al 2012 |
| GTV | 41 | 3 | CT, PETCT, MRI | CI(GTV-P) = 0.54-0.62 CI(GTV-N)>0.75 | Thiagajaran et al 2012 | |
| CTV, CTVE | 10 | 10 | CT, MRI | localSD(CTV) = 3.3-4.4mm localSD(CTVe) = 4.9-5.9mm | Rasch et al 2012 | |
| Lung | GTV | 12 | 8 | CT, CBCT | CI = 0.27-0.39 CIgen = 0.58-0.70 | Altorjai et al 2012 |
| GTV | 8 | 5 | CT | Vmax/Vmin>7 | Van De Steene et al 2002 | |
| GTV | 10 | 17 | CT | Vmax/Vmin = 5.2 CI = 0.04-0.48 | Giraud et al 2002 | |
| GTV | 22 | 11 | CT, PETCT | meanCI = 0.17(CT),0.29(PETCT) localSD = 1cm(CT),0.4cm(PETCT) | Steenbakers et al 2006 | |
| GTV | 19 | 2 | CT, PETCT | medianCI(CT) = 0.61, medianCI(PETCT) = 0.70 | Fox et al 2005 | |
| Brain | CTV | 7 | 5 | CT + MRI | CI = 0.14-0.47 | Cattaneo et al 2005 |
| GTV | 5 | 9 | CT, MRI | Vmax/Vmin(CT) = 1.7-2.8 Vmax/Vmin(MR) = 1.5-2.7 | Weltens et al 2001 | |
| Prostate | Prostate, seminal vesicles (SV) | 10 | 7 | CT | Vmax/Vmin(P) = 1.18-1.63 Vmax/Vmin(SV) = 2.02-6.43 | Valicenti et al 1999 |
| Prostate | 3 | 2 | CT | Vmax/Vmin = 1.39-1.65 | Seddon et al 2000 | |
| Prostate | 5 | 5 | CT, MRI | MeanCI(MR)CI = 0.83 MeanCI(CT) = 0.69 | Segedin et al 2011 | |
| Breast | Lumpectomy cavity (LC), CTV | 15 | 3 | CT, MRI | CI(LC) = 0.32(MR),0.52(CT) CI(CTV) = 0.77(CT),0.79(MR) | Giezen et al 2011,2012 |
| Lumpectomy cavitiy | 30 | 5 | CT | MeanCI = 0.36 | Boersma et al 2012 | |
| Lumpectomy cavity, CTV, PTV | 8 | 13 | CT | CI(LC) = 0.19-0.77 CI(CTV) = 0.38-0.80 CI(PTV) = 0.45-0.81 | VanMourik et al 2010 | |
| Lumpectomy cavity, PTV | 9 5 | 5 4 | CT | CI(LC) = 0.48-0.52 CI(PTV) = 0.55-0.59 Vmax/Vmin = 2.2-2.8 | Major et al 2015 | |
| Lumpectomy cavity, CTV | 18 | 5 | CT | MeanCI(LC) = 0.56 MeanCI(CTV) = 0.87 | Struikmans et al 2005 |