A prototype of a flexible grid electrode to treat widespread superficial tumors by means of Electrochemotherapy
References
- Mir LM, Orlowski S. Mechanisms of electrochemotherapy. Adv Drug Deliv Rev 1999; 35: 107–18.
- Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek J, Mir LM. Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer 1993; 72: 3694–700
- Mali B, Jarm T, Snoj M, Sersa G, Miklavcic D. Antitumor effectiveness of electrochemotherapy: A systematic review and meta-analysis. Eur J Surg Oncol 2013; 39: 4–16
- Mir LM, Glass LF, Sersa G, Teissié J, Domenge C, Miklavcic D, et al. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer 1998; 77: 2336–42
- Mir LM. Therapeutic perspectives of in vivo cell electropermeabilization. Bioelectrochemistry 2001; 53: 1–10
- Gothelf A, Mir LM, Gehl J. Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treat Rev. 2003; 29: 371–87
- Chen C, Smye SW, Robinson MP, Evans JA. Membrane electroporation theories: a review. Med Biol Eng Comput 2006; 44: 5–14
- Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M, et al. Electrochemotherapy–An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl 2006; 4: 3–13
- Campana L, Mocellin S, Basso M, Puccetti O, De Salvo G, Chiarion-Sileni V, et al. Bleomycin-based electrochemotherapy: clinical outcome from a single institution’s experience with 52 patients. Ann Surg Oncol 2009; 16: 191–9
- Campana L, Valpione S, Falci C, Mocellin S, Basso M, Corti L, et al. The activity and safety of electrochemotherapy in persistent chest wall recurrence from breast cancer after mastectomy: a phase-II study. Breast Cancer Res Treat 2012; 134:1169-78.
- Campana L, Bianchi G, Mocellin S, Valpione S, Campanacci L, Brunello A, et al. Electrochemotherapy treatment of locally advanced and metastatic soft tissue sarcomas: results of a non-comparative phase II study. World J Surg 2014: 38: 813–22
- Valpione S, Campana LG, Pigozzo J, Chiarion-Sileni V. Consolidation electrochemotherapy with bleomycin in metastatic melanoma during treatment with dabrafenib. Radiol Oncol 2015; 49: 71–4.
- Campana LG, Scarpa M, Sommariva A, Bonandini E, Valpione S, Sartore L, Rossi CR. Minimally invasive treatment of peristomal metastases from gastric cancer at an ileostomy site by electrochemotherapy. Radiol Oncol 2013; 47: 370–5
- Buchanan CL, Dorn PL, Fey J, Giron G, Naik A, Mendez J, et al. Locoregional recurrence after mastectomy: incidence and outcomes. J Am Coll Surg. 2006; 203: 469–74
- Schmoor C, Sauerbrei W, Bastert G, Schumacher M. Role of isolated locoregional recurrence of breast cancer: results of four prospective studies. J Clin Oncol 2000; 18: 1696–708
- Andry G, Suciu S, Vico P, Faverly D, Andry-t’Hooft M, et al. Locoregional recurrences after 649 modified radical mastectomies: incidence and significance. Eur J Surg Oncol 1989; 15: 476–85
- Cheng SH, Horng CF, Clarke JL, Tsou MH, Tsai SY, Chen CM, et al. Prognostic index score and clinical prediction model of local regional recurrence after mastectomy in breast cancer patients. Int J Radiat Oncol Biol Phys 2006; 64: 1401–9
- Nielsen HM, Overgaard M, Grau C, Jensen AR, Overgaard J. Loco-regional recurrence after mastectomy in high-risk breast cancer--risk and prognosis. An analysis of patients from the DBCG 82 b&c randomization trials. Radiother Oncol 2006; 79: 147–55
- Sersa G, Cufer T, Paulin SM, Cemazar M, Snoj M. Electrochemotherapy of chest wall breast cancer recurrence. Cancer Treat Rev 2012; 38: 379–86
- Campana LG, Falci C, Basso M, Sieni E, Dughiero F. Clinical electrochemotherapy for chest wall recurrence from breast cancer. In: Sundarajan R, editor. Electroporation-based therapies for cancer. Elsevier; 2014. p. 3–33
- Mir LM, Gehl J, Sersa G, Collins CG, Garbay J-R, Billard V, et al. Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. EJC Suppl 2006; 4: 14–25
- Heller R, Jaroszeski MJ, Gilbert R. Electromanipulation device and method. 2010. USA Patent 7,769,440
- Ferraro B, Heller LC, Cruz YL, Guo S, Donate A, Heller R. Evaluation of delivery conditions for cutaneous plasmid electrotransfer using a multielectrode array. Gene Therapy 2011; 18: 496–500
- Heller R, Cruz Y, Heller LC, Gilbert RA, Jaroszeski MJ. Electrically mediated delivery of plasmid DNA to the skin, using a multielectrode array. Hum Gene Ther 2010; 21: 357–62
- Bommakanti S, Agoramurthy P, Campana L, Sundararajan R. A simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissues. In: Electrical Insulation and Dielectric Phenomena (CEIDP), 2011 Annual report conference on electrical insulation and dielectric phenomena. Cancun, Mexico 2011: 187–90 doi:10.1109/CEIDP.2011.6232628.
- Agoramurthy P, Campana L, Sundararajan R. Finite element modeling and analysis of human breast tissue for electrochemotherapy. In: IEEE; 2011: 191–4 doi:10.1109/CEIDP.2011.6232629.
- Gilbert RA, Jaroszeski MJ, Heller R. Novel electrode designs for electrochemotherapy. Biochim Biophys Acta 1997; 1334: 9–14
- Castiello M, Dughiero F, Scandola F, Sieni E, Campana LG, Rossi CR, et al. A new grid electrode for electrochemotherapy treatment of large skin tumors. Dielectrics and Electrical Insulation, IEEE Transactions on Electrical Insulation and Dielectric Phenomena. 2014; 21(3): 1424–32 doi:10.1109/TDEI.2014.6832291.
- Nenzi P, Denzi A, Kholostov K, Crescenzi R, Apollonio F, Liberti M, et al. Smart flexible planar electrodes for electrochemotherapy and biosensing. Electronic Components and Technology Conference (ECTC), 2013 IEEE 63rd. May 2013: 486–93 doi:10.1109/ECTC.2013.6575616.
- Ongaro A, Campana LG, De Mattei M, Dughiero F, Forzan MM, Pellati A, et al. Evaluation of the electroporation efficiency of a grid electrode for electrochemotherapy: from numerical model to in vitro tests. Technol Cancer Res Treatm. In press. doi: 10.1177/1533034615582350
- Ongaro A, Campana LG, De Mattei M, Dughiero F, Forzan M, Pellati A, et al. Effect of electrode distance in electrochemotherapy: from numerical model to in vitro tests. In: Jarm T, Kramar P, eds. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies. Vol 53. IFMBE Proceedings. Singapore: Springer; 2016. p. 167–70 Available at: http://dx.doi.org/10.1007/978-981-287-817-5_37.
- IGEA. [Cited 15 Apr 2014]. Available at: http://www.igeamedical.com/.
- Bertacchini C, Margotti PM, Bergamini E, Lodi A, Ronchetti M, Cadossi R. Design of an irreversible electroporation system for clinical use. Technol Cancer Res Treat 2007; 6: 313–20
- Hjouj M, Rubinsky B. Magnetic resonance imaging characteristics of non-thermal irreversible electroporation in vegetable tissue. J Membrane Biol 2010; 236: 137–46
- Ivorra A, Mir LM, Rubinsky B. Electric field redistribution due to conductivity changes during tissue electroporation: Experiments with a Simple Vegetal Model. In: Dössel O, Schlegel W, editors. World Congress on Medical Physics and Biomedical Engineering, September 7–12, 2009, Munich, Germany. Vol 25/13. IFMBE Proceedings. Berlin Heidelberg: Springer; 2010. p. 59–62 Available at http://dx.doi.org/10.1007/978-3-642-03895-2_18.
- Corovic S, Lackovic I, Sustaric P, Sustar T, Rodic T, Miklavcic D. Modeling of electric field distribution in tissues during electroporation. Biomed Eng Online 2013; 12: 16.
- Miklavcic D, Snoj M, Zupanic A, Kos B, Cemazar M, Kropivnik M, et al. Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy. Biomed Eng Online 2010; 9: 10.
- Pavselj N, Miklavcic D. Numerical models of skin electropermeabilization taking into account conductivity changes and the presence of local transport regions. Plasma Science, IEEE Transactions on 2008; 36: 1650–8
- Corovic S, Zupanic A, Miklavcic D. Numerical modeling and optimization of electric field distribution in subcutaneous tumor treated with electrochemotherapy using needle electrodes. Plasma Science, IEEE Transactions on 2008; 36: 1665–72
- Suárez C, Soba A, Maglietti F, Olaiz N, Marshall G. The role of additional pulses in electropermeabilization protocols. PLoS ONE 2014; 9: e113413.
- Castellví Q, Banús J, Ivorra A. 3D Assessment of Irreversible Electroporation Treatments in Vegetal Models. In: Jarm T, Kramar P, eds. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies. Vol 53. Singapore: Springer; 2016. p. 294–7
- Ivorra A, Villemejane J, Mir LM. Electrical modeling of the influence of medium conductivity on electroporation. Phys Chem Chem Phys 2010; 12: 1055–64
- Whelan MC, Larkin JO, Collins CG, Cashman J, Breathnach O, Soden DM, et al. Effective treatment of an extensive recurrent breast cancer which was refractory to multimodal therapy by multiple applications of electrochemotherapy. Eur J Cancer Suppl 2006; 4: 32–4
- F. Dughiero, E. Sieni, C. R. Rossi, L. G. Campana, Patent No. VR2013A00184 “APPLICATORE PER ELETTROPORAZIONE”, 01/08/2013.
Language: English
Page range: 49 - 57
Submitted on: Nov 3, 2015
Accepted on: Jan 20, 2016
Published on: Feb 16, 2016
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Related subjects:
© 2016 Luca G. Campana, Fabrizio Dughiero, Michele Forzan, Carlo R. Rossi, Elisabetta Sieni, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.