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A prototype of a flexible grid electrode to treat widespread superficial tumors by means of Electrochemotherapy

Radiology and Oncology
Volume 50 (2016): Issue 1 (March 2016)
By:
Open Access
|Feb 2016

Figures & Tables

Figure 1.

Chest wall recurrence from breast cancer and development of the grid electrode. (A) An example of a breast cancer patients who underwent repetitive ECT cycles to treat cutaneous metastases. The extension of electrode-induced skin marks highlights the extension of the treatment field and the need for more effective pulse delivery. (B) Sketch of the device, (C) resulting electric field lines of a grid electrode and (D) electric field color map.
Chest wall recurrence from breast cancer and development of the grid electrode. (A) An example of a breast cancer patients who underwent repetitive ECT cycles to treat cutaneous metastases. The extension of electrode-induced skin marks highlights the extension of the treatment field and the need for more effective pulse delivery. (B) Sketch of the device, (C) resulting electric field lines of a grid electrode and (D) electric field color map.

Figure 2.

Prototypes of the flexible electrode: (A) device with diameter 8 cm with hexagonal electrode disposition, (B) removable needles inserted in electrical connection and (C) square device 15 × 15 cm with hexagonal arrangement of conductive guides highlighted.
Prototypes of the flexible electrode: (A) device with diameter 8 cm with hexagonal electrode disposition, (B) removable needles inserted in electrical connection and (C) square device 15 × 15 cm with hexagonal arrangement of conductive guides highlighted.

Figure 3.

(A) Connection box to interface the flexible electrode to the voltage pulse generator. (B) Schema of the arrangement of clamps and (C) examples of connections.
(A) Connection box to interface the flexible electrode to the voltage pulse generator. (B) Schema of the arrangement of clamps and (C) examples of connections.

Figure 4.

Potato tuber after 24 h preserved at room temperature: (A) no voltage pulses (control) and (B) treated with voltage pulses.
Potato tuber after 24 h preserved at room temperature: (A) no voltage pulses (control) and (B) treated with voltage pulses.

Figure 5.

(A) Phantom used to test the square flexible electrode with side 15 cm. (B) Manual insertion of needles, (C) device ready for pulse application and (D) connection of the electrode with the connection box.
(A) Phantom used to test the square flexible electrode with side 15 cm. (B) Manual insertion of needles, (C) device ready for pulse application and (D) connection of the electrode with the connection box.

Figure 6.

(A) Potato tuber surface appears dark after 24 h from voltage pulse application and (B) effect of voltage pulses inside the potato.
(A) Potato tuber surface appears dark after 24 h from voltage pulse application and (B) effect of voltage pulses inside the potato.

Figure 7.

(A) Potato phantom surface appears dark after 24 h from voltage pulse application and (B) effect of voltage pulses inside the potato.
(A) Potato phantom surface appears dark after 24 h from voltage pulse application and (B) effect of voltage pulses inside the potato.

Example of supply needle pair sequence

#STEPNeedle pair#STEPNeedle pair
#11–2#14A–3
#21–3#15A–4
#31–4#16A–5
DOI: https://doi.org/10.1515/raon-2016-0013 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
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Language: English
Page range: 49 - 57
Submitted on: Nov 3, 2015
Accepted on: Jan 20, 2016
Published on: Feb 16, 2016
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
electrochemotherapy,
electrode,
flexible support,
breast cancer recurrence
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology,
Radiology

© 2016 Luca G. Campana, Fabrizio Dughiero, Michele Forzan, Carlo R. Rossi, Elisabetta Sieni, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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