Figure 1.
Figure 2.
Results from the Multivariate Regression Analysis
| Variable | Regression coefficient (B) | se | p | 95% CI |
| Tumour grade | 0.807 | 0.236 | 0.001 | 0.338-1.276 |
| HR status | 0.086 | 0.249 | 0.729 | −0.408-0.581 |
| BTS (MRI) | 0.610 | 0.277 | 0.030 | 0.060-1.161 |
Clinical and tumour characteristics
| CONTINUOUS VARIABLES | Mean | SD | Median | Range |
|---|---|---|---|---|
| AGE (years) | 47.22 | 10.10 | 42.0 | 31.0–75.0 |
| BASAL TUMOR SIZE (cm) | 3.99 | 1.97 | 3.40 | 1.60–13.0 |
MRI diagnostic performance in predicting pathologic response
| Pathology | Total | |||
|---|---|---|---|---|
| No pCR | pCR | |||
| MRI | No iCR | TP = 48 | FP = 6 | 54 (58.70%) |
| iCR | FN = 16 | TN = 22 | 38 (41.30%) | |
| Total | 64 (69.60%) | 28 (30.40%) | 92 (100%) | |
Factors affecting the MRI diagnostic accuracy based on the discrepancy between MRI and pathologic residual tumour size
| Variable | No. | Discrepancy (mean ± SD) | p-value |
|---|---|---|---|
| Age (years) | |||
| ≤45 | 43 | 1.09±1.14 | 0.281 |
| > 45 | 46 | 0.84 ±1.01 | |
| Baseline tumour size (cm) | |||
| ≤5 | 74 | 0.85 ±0.99 | 0.050 |
| >5 | 15 | 1.53 ±1.33 | |
| Histological type | 0.818 | ||
| ductal | 83 | 0.97 ±1.09 | |
| lobular | 6 | 0.87 ±0.82 | |
| Histological grade | <0.001 | ||
| 1 or 2 | 40 | 1.44 ±1.24 | |
| 3 | 47 | 0.56 ±0.71 | |
| Hormonal receptor status | 0.033 | ||
| positive | 59 | 1.14 ±1.13 | |
| negative | 30 | 0.63 ±0.87 | |
| HER2 status | 0.906 | ||
| positive | 24 | 0.99 ±1.12 | |
| negative | 65 | 0.96 ±1.07 | |
| Molecular subtype | 0.055 | ||
| Luminal A | 10 | 1.59 ±1.34 | |
| Luminal B-HER2− | 34 | 1.05 ±1.06 | |
| Luminal B-HER2+ | 15 | 1.02 ±1.14 | |
| HER2+ | 9 | 0.92 ±1.14 | |
| Triple negative | 21 | 0.50 ±0.70 | |