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The impact of anaemia on treatment outcome in patients with squamous cell carcinoma of anal canal and anal margin

Radiology and Oncology
Volume 50 (2016): Issue 1 (March 2016)
By:
Open Access
|Feb 2016

Figures & Tables

Haemoglobin (Hb) values in subgroups of patients

Hb (g/L)No. of patientsMedian Hb (g/L)Hb range (g/L)
Pre-treatment Hb12886–169
  > 120 g/L69136122–169
  ≤ 120 g/L3110786–120
Mean on-treatment Hb12796–157
  >120 g/L67134121–157
  ≤ 120 g/L3311396–119
End-of-treatment Hb12177–159
  > 120 g/L46134121–159
  ≤ 120 g/L5411477–120

Acute treatment toxicities

ToxicityGrade
01234Total
Stomatitis68121091100
Nausea, vomiting799930100
Diarrhoea571712131100
Hand-foot syndrome

Only in patients treated with capecitabine

22012025
Radiodermatitis101213641100
Infection51142393100
Leucocyte count373120102100
Haemoglobin level43441120100
Platelet count5836330100

Univariate analysis of survival of patients at 5 years by Hb level, tumour-, patients-, and treatment characteristics

CharacteristicsnLRCDFSDSSOS
Pre-treatment Hb
79%77%85%73%
 > 120 g/L69
57%57%56%39%
 ≤ 120 g/L31
P = 0.011P = 0.017P = 0.003P = 0.000
Mean on-treatment Hb
78%76%82%68%
 > 120 g/L67
60%60%67%50%
 ≤ 120 g/L33
P = 0.037P = 0.054P = 0.081P = 0.007
End-of-treatment Hb
82%80%89%75%
 > 120 g/L46
63%63%65%49%
 ≤ 120 g/L54
P = 0.022P = 0.037P = 0.011P = 0.003
Performance status
73%73%80%72%
  PS 076
69%64%66%34%
  PS 1–324
P = 0.480P = 0.283P = 0.231P = 0.000
Tumour stage
75%75%84%68%
T1–386
50%44%38%25%
T414
P = 0.054P = 0.015P = 0.000P = 0.001
Lymph node involvement
no6579%79%87%70%
yes3559%56%60%48%
P = 0.032P = 0.017P = 0.000P = 0.000
Overall disease stage
79%79%87%70%
I / II
64
IIIA / IIIB59%57%61%49%
36
P = 0.044P = 0.025P = 0.000P = 0.000
Histologic tumour type
basaloid12100%100%100%100%
squamous8868%67%74%57%
P = 0.030P = 0.026P = 0.051P = 0.016
Tumour site
69%68%78%62%
anal canal72
81%81%73%61%
anal margin28
P = 0.250P = 0.212P = 0.994P = 0.738
Blood transfusion
no72%71%78%64%
91
yes0%0%0%0%
9
P = 0.993P = 0.950P = 0.333P = 0.044
Overall radiation time
89%89%93%83%
≤ 1,08 months29
64%63%69%51%
> 1,08 months71
P = 0.015P = 0.011P = 0.012P = 0.012
Operation
no7389%88%88%69%
yes2729%29%52%45%
P = 0.000P < 0.000P = 0.001P = 0.018

Patients’ and tumours’ characteristics

CharacteristicsNo. of patients
Gender
 female60
 male40
Mean age (range)63 (34–87)
Performance status (WHO)
 076
 120
 23
 31
Tumour type
 Carcinoma of the anal canal72
 Carcinoma of the anal margin28
Tumour histology
Basaloid12
Squamous88
TNMN0N1N2N3
 T19010
 T236610
 T3191031
 T41175
Tumour stage
 I9
 II55
 IIIA17
 IIIB19
DOI: https://doi.org/10.1515/raon-2015-0015 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
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Language: English
Page range: 113 - 120
Submitted on: Nov 26, 2014
Accepted on: Dec 22, 2014
Published on: Feb 16, 2016
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
anaemia,
anal canal squamous cell carcinoma,
radiochemotherapy
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology,
Radiology

© 2016 Irena Oblak, Monika Cesnjevar, Mitja Anzic, Jasna But Hadzic, Ajra Secerov Ermenc, Franc Anderluh, Vaneja Velenik, Ana Jeromen, Peter Korosec, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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