Two (Sulfone-Amidosulphonyl)-Amides Derived from N-(P-Amidobenzoyl)-L-Glutamine; Optimized Synthesis and Toxicity Study

Corina Cheptea; Andreea Celia Benchea; Marius Gaina; Dana Ortansa Dorohoi; Valeriu Sunel

doi:10.1515/kbo-2016-0105

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Two (Sulfone-Amidosulphonyl)-Amides Derived from N-(P-Amidobenzoyl)-L-Glutamine; Optimized Synthesis and Toxicity Study

International conference KNOWLEDGE-BASED ORGANIZATION

Volume 22 (2016): Issue 3 (June 2016)

By: Corina Cheptea, Andreea Celia Benchea, Marius Gaina, Dana Ortansa Dorohoi and Valeriu Sunel

Open Access

|Jul 2016

Abstract

Two derivatives of glutamine were synthesized and the most convenient physical conditions for obtaining reactions were established in factorial experiments with temperature and time of reactions considered as relevant variables. A quantum-mechanical characterization for the new compounds was performed by using HyperChem 8.0.6 Programs and their physical and chemical properties were theoretically estimated. The toxicity of two new compounds was experimentally determined.

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Articles in this issue

DOI: https://doi.org/10.1515/kbo-2016-0105 | Journal eISSN: 2451-3113

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Language: English

Page range: 609 - 615

Published on: Jul 27, 2016

Published by: Nicolae Balcescu Land Forces Academy

In partnership with: Paradigm Publishing Services

Publication frequency: 3 issues per year

Keywords:

N-[p-(R)-Benzoyl]-L-Glutamine derivatives,

factorial experiment for optimization,

QSAR parameters,

toxicity test

Related subjects:

Business and economics,

Business management,

Management, organization, corporate governance,

Engineering,

Introductions and overviews,

Law,

© 2016 Corina Cheptea, Andreea Celia Benchea, Marius Gaina, Dana Ortansa Dorohoi, Valeriu Sunel, published by Nicolae Balcescu Land Forces Academy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 22 (2016): Issue 3 (June 2016)