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Chemical profile of Senna italica and Senna velutina seed and their pharmacological properties Cover

Chemical profile of Senna italica and Senna velutina seed and their pharmacological properties

Open Access
|Jun 2025

References

  1. Zhang Y, Wang P, Jia Z, Zheng Z, Wang J, Liang H. Global burden and risk factors of male cancers from 1990 to 2021, with forecasts to 2040. Sci Rep. 2025;15:5123.
  2. Almohammadi NH. Liver cancer in Saudi Arabia: A registry-based nationwide descriptive epidemiological and survival analysis. Cancer Epidemiol. 2025;94:102731.
  3. Arzanova E, Mayrovitz HN. The epidemiology of breast cancer. Exon Publ. 2022;1–19.
  4. Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5:e47.
  5. Paz JEW, Contreras CR, Munguía AR, Aguilar CN, Inungaray MLC. Phenolic content and antibacterial activity of extracts of Hamelia patens obtained by different extraction methods. Braz J Microbiol. 2018;49:656–61.
  6. Bourais I, Elmarrkechy S, Taha D, Mourabit Y, Bouyahya A, El Yadini M, et al. A review on medicinal uses, nutritional value, and antimicrobial, antioxidant, anti-inflammatory, antidiabetic, and anticancer potential related to bioactive compounds of J. regia. Food Rev Int. 2022;39:1–51.
  7. Hashem S, Ali TA, Akhtar S, Nisar S, Sageena G, Ali S, et al. Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents. Biomed Pharmacother. 2022;150:113054.
  8. Bhilkar P, Bodhne A, Yerpude S, Madankar R, Somkuwar S, Chaudhary A, et al. Phyto-derived metal nanoparticles: prominent tool for biomedical applications. OpenNano. 2023;14:100192.
  9. Gahtori R, Tripathi AH, Kumari A, Negi N, Paliwal A, Tripathi P, et al. Anticancer plant-derivatives: Deciphering their oncopreventive and therapeutic potential in molecular terms. Future J Pharm Sci. 2023;9:14.
  10. Goel H, Kumar R, Tanwar P, Upadhyay TK, Khan F, Pandey P, et al. Unraveling the therapeutic potential of natural products in the prevention and treatment of leukemia. Biomed Pharmacother. 2023;160:114351.
  11. Nirmala NS, Krishnan NB, Vivekanandan V, Thirugnanasambantham K. Anti-inflammatory potential of lead compounds and their derivatives from medicinal plants. Bioprospecting of tropical medicinal plants. Heidelberg, Germany: Springer; 2023. p. 1199–232.
  12. Adedokun KA, Imodoye SO, Bello IO, Lanihun A-A. Therapeutic potentials of medicinal plants and significance of computational tools in anti-cancer drug discovery. Phytochemistry, computational tools and databases in drug discovery. Amsterdam, Netherlands: Elsevier; 2023. p. 393–455.
  13. Oladeji OS, Adelowo FE, Oluyori AP. The genus Senna (Fabaceae): A review on its traditional uses, botany, phytochemistry, pharmacology and toxicology. South Afr J Botany. 2021;138:1–32.
  14. Alshehri MM, Quispe C, Herrera-Bravo J, Sharifi-Rad J, Tutuncu S, Aydar EF, et al. A review of recent studies on the antioxidant and anti‐infectious properties of senna plants. Oxid Med Cell Longev. 2022;2022:6025900.
  15. Marazzi B, Endress PK. Patterns and development of floral asymmetry in Senna (Leguminosae, Cassiinae). Am J Botany. 2008;95:22–40.
  16. Towanou R, Konmy B, Yovo M, Dansou CC, Dougnon V, Loko FS, et al. Phytochemical screening, antioxidant activity, and acute toxicity evaluation of Senna italica extract used in traditional medicine. J Toxicol. 2023;2023:6405415.
  17. Ikram A, Khalid W, Saeed F, Arshad MS, Afzaal M, Arshad MU. Senna: As immunity boosting herb against COVID-19 and several other diseases. J Herb Med. 2023;37:100626.
  18. Sitarek P, Sikora J, Dudzic M, Boczkowski D, Osicka W, Ghorbanpour M, et al. Plant secondary metabolites of the genus senna. biological properties in the context of medical research. Plant specialized metabolites: Phytochemistry, ecology and biotechnology. Heidelberg, Germany: Springer; 2023. p. 1–29.
  19. Manosroi A, Akazawa H, Kitdamrongtham W, Akihisa T, Manosroi W, Manosroi J. Potent antiproliferative effect on liver cancer of medicinal plants selected from the Thai/Lanna medicinal plant recipe database “MANOSROI III”. J Evidence-Based Complementary Altern Med. 2015;2015:397181.
  20. Onyegeme-Okerenta B, Spriggs K, Bradshaw T. Ethyl acetate extract of Senna alata (L) Roxb increases cytotoxicity in the human breast, prostate and colorectal cancer cells. J Cancer Treat Res. 2018;6:44–53.
  21. Castro DTH, Leite DF, da Silva Baldivia D, Dos Santos HF, Balogun SO, da Silva DB, et al. Structural characterization and anticancer activity of a new anthraquinone from Senna velutina (Fabaceae). Pharmaceuticals. 2023;16:951.
  22. Alharbi NS, Khaled JM, Alanazi K, Kadaikunnan S, Alobaidi AS. Biosynthesis of silver nanoparticles (Ag-NPs) using Senna alexandrina grown in Saudi Arabia and their bioactivity against multidrug-resistant pathogens and cancer cells. Saudi Pharm J. 2023;31:911–20.
  23. Tatsimo SJN, Tsague VT, Lamshoft M, Sarkar P, Bag PK, Spiteller M. Antibacterial-guided isolation of constituents from Senna alata leaves with a particular reference against Multi-Drug-Resistant Vibrio cholerae and Shigella flexneri. Int J Biol Chem Sci. 2017;11:46–53.
  24. Masoko P, Gololo SS, Mokgotho MP, Eloff JN, Howard R, Mampuru L. Evaluation of the antioxidant, antibacterial, and antiproliferative activities of the acetone extract of the roots of Senna italica (Fabaceae). Afr J Tradit Complementary Altern Med. 2010;7:138–48.
  25. Campos JF, de Castro DTH, Damiao MJ, Vieira Torquato HF, Paredes-Gamero EJ, Carollo CA, et al. Santos ELd. The chemical profile of Senna velutina leaves and their antioxidant and cytotoxic effects. Oxid Med Cell Longev. 2016;2016:8405957.
  26. Aamer HA, Al-Askar AA, Gaber MA, El-Tanbouly R, Abdelkhalek A, Behiry S, et al. Extraction, phytochemical characterization, and antifungal activity of Salvia rosmarinus extract. Open Chem. 2023;21:20230124.
  27. Sultana B, Anwar F, Ashraf M. Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts. Molecules. 2009;14:2167–80.
  28. Marimoutou M, Le Sage F, Smadja J, Lefebvre d’Hellencourt C, Gonthier M-P, Robert-Da Silva C. Antioxidant polyphenol-rich extracts from the medicinal plants Antirhea borbonica, Doratoxylon apetalum and Gouania mauritiana protect 3T3-L1 preadipocytes against H2O2, TNFα and LPS inflammatory mediators by regulating the expression of superoxide dismutase and NF-κB genes. J Inflamm. 2015;12:1–15.
  29. Abbas A, Naqvi SAR, Rasool MH, Noureen A, Mubarik MS, Tareen RB. Phytochemical analysis, antioxidant and antimicrobial screening of Seriphidium oliverianum plant extracts. Dose-response. 2021;19:15593258211004739.
  30. Youssef AMM, Maaty DAM, Al-Saraireh YM. Phytochemical analysis and profiling of antitumor compounds of leaves and stems of calystegia silvatica (Kit.) Griseb. Molecules. 2023;28:630.
  31. Wolfe KL, Liu RH. Apple peels as a value-added food ingredient. J Agric Food Chem. 2003;51:1676–83.
  32. Ordonez A, Gomez J, Vattuone M. Antioxidant activities of Sechium edule (Jacq.) Swartz extracts. Food Chem. 2006;97:452–8.
  33. Tian M, Wu X, Lu T, Zhao X, Wei F, Deng G, et al. Phytochemical analysis, antioxidant, antibacterial, cytotoxic, and enzyme inhibitory activities of Hedychium flavum rhizome. Front Pharmacol. 2020;11:572659.
  34. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55–63.
  35. Alkhudhayri AA, Wahab R, Siddiqui MA, Ahmad J. Selenium nanoparticles induce cytotoxicity and apoptosis in human breast cancer (MCF-7) and liver (HEPG2) cell lines. Nanosci Nanotechnol Lett. 2020;12:324–30.
  36. Ghasemi M, Turnbull T, Sebastian S, Kempson I. The MTT assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis. Int J Mol Sci. 2021;22:12827.
  37. Al-Dhabi NA, Valan Arasu M. Quantification of phytochemicals from commercial Spirulina products and their antioxidant activities. J Evidence-Based Complementary Altern Med. 2016;2016:7631864.
  38. Salem N, Kefi S, Tabben O, Ayed A, Jallouli S, Feres N, et al. Variation in chemical composition of Eucalyptus globulus essential oil under phenological stages and evidence synergism with antimicrobial standards. Ind Crop Products. 2018;124:115–25.
  39. Basri DF, Sandra V. Synergistic interaction of methanol extract from Canarium odontophyllum Miq. Leaf in combination with oxacillin against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33591. Int J Microbiol. 2016;2016:5249534–41.
  40. Aljeldah MM, Yassin MT, Mostafa AA-F, Aboul-Soud MA. Synergistic antibacterial potential of greenly synthesized silver nanoparticles with fosfomycin against some nosocomial bacterial pathogens. Infect Drug Resist. 2022;16:125–42.
  41. Allaqaband S, Dar AH, Patel U, Kumar N, Nayik GA, Khan SA, et al. Utilization of fruit seed-based bioactive compounds for formulating the nutraceuticals and functional food: A review. Front Nutr. 2022;9:902554.
  42. Majeed T, Bhat NA. Health benefits of plant extracts. Plant extracts: applications in the food industry. Elsevier; 2022. p. 269–94.
  43. Ghafoori H, Sariri R, Naghavi M. Study of effect of extraction conditions on the biochemical composition and antioxidant activity of Artemisia absinthium by HPLC and TLC. J Liq Chromatogr Relat Technol. 2014;37:1558–67.
  44. Adjou ES, Koudoro AY, Nonviho G, Ahoussi ED, Sohounhloue DC. Phytochemical profile and potential pharmacological properties of leaves extract of Senna italica Mill. Am J Pharmacol Sci. 2021;9:36–9.
  45. Cosmulescu S, Trandafir I, Nour V. Phenolic acids and flavonoids profiles of extracts from edible wild fruits and their antioxidant properties. Int J Food Prop. 2017;20:3124–34.
  46. Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, et al. Important flavonoids and their role as a therapeutic agent. Molecules. 2020;25:5243.
  47. He M, Yasin K, Yu S, Li J, Xia L. Total flavonoids in Artemisia absinthium L. and evaluation of its anticancer activity. Int J Mol Sci. 2023;24:16348.
  48. Singh J, Prasad R, Kaur HP, Jajoria K, Chahal AS, Verma A, et al. Bioactive compounds, pharmacological properties, and utilization of pomegranate (Punica granatum L.): a comprehensive review. Trop J Nat Prod Res. 2023;7(9):3856–73.
  49. Pérez M, Dominguez-López I, Lamuela-Raventós RM. The chemistry behind the folin–ciocalteu method for the estimation of (poly) phenol content in food: Total phenolic intake in a mediterranean dietary pattern. J Agric Food Chem. 2023;71:17543–53.
  50. Ganesan T, Subban M, Christopher Leslee DB, Kuppannan SB, Seedevi P. Structural characterization of n-hexadecanoic acid from the leaves of Ipomoea eriocarpa and its antioxidant and antibacterial activities. Biomass Convers Biorefin. 2024;14:14547–58.
  51. Shaaban MT, Ghaly MF, Fahmi SM. Antibacterial activities of hexadecanoic acid methyl ester and green‐synthesized silver nanoparticles against multidrug‐resistant bacteria. J Basic Microbiol. 2021;61:557–68.
  52. Martínez-Ceja A, Romero-Estrada A, Columba-Palomares MC, Hurtado-Díaz I, Alvarez L, Teta-Talixtacta R, et al. Bernabé-Antonio A. Anti-inflammatory, antibacterial and antioxidant activity of leaf and cell cultures extracts of Randia aculeata L. and its chemical components by GC-MS. South Afr J Bot. 2022;144:206–18.
  53. Qiu Y, Li A, Lee J, Lee JE, Lee E-W, Cho N, et al. Inhibition of Jurkat T cell proliferation by active components of Rumex japonicus roots via induced mitochondrial damage and apoptosis promotion. J Microbiol Biotechnol. 2020;30:1885.
  54. Dong M, Oda Y, Hirota M. (10E, 12Z, 15Z)-9-hydroxy-10, 12, 15-octadecatrienoic acid methyl ester as an anti-inflammatory compound from Ehretia dicksonii. Biosci Biotechnol Biochem. 2000;64:882–6.
  55. López-Lázaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem. 2009;9:31–59.
  56. Kahrizi D, Mohammadi S. Anticancer, antimicrobial, cardioprotective, and neuroprotective activities of luteolin: A systematic-narrative mini-review. Nano Micro Biosyst. 2023;2:1–9.
  57. Olszowy M, Dawidowicz AL. Is it possible to use the DPPH and ABTS methods for reliable estimation of antioxidant power of colored compounds? Chem Pap. 2018;72:393–400.
  58. Platzer M, Kiese S, Herfellner T, Schweiggert-Weisz U, Miesbauer O, Eisner P. Common trends and differences in antioxidant activity analysis of phenolic substances using single electron transfer based assays. Molecules. 2021;26:1244.
  59. Sun Y, Lenon GB, Yang AW. Rumex japonicus Houtt.: A phytochemical, pharmacological, and pharmacokinetic review. Phytother Res. 2020;34:1198–215.
  60. Purushothaman R, Vishnuram MG, Ramanathan DT. Isolation and identification of N-hexadecanoic acid from excoecaria agallocha L. and its antibacterial and antioxidant activity. J Emerg Technol Innovative Res. 2024;11:332–42.
  61. Rahman MA, Hannan MA, Dash R, Rahman MH, Islam R, Uddin MJ, et al. Phytochemicals as a complement to cancer chemotherapy: pharmacological modulation of the autophagy-apoptosis pathway. Front Pharmacol. 2021;12:639628.
  62. Madkour HM, Ghareeb MA, Abdel-Aziz MS, Khalaf OM, Saad AM, El-Ziaty AK, et al. Gas chromatography-mass spectrometry analysis, antimicrobial, anticancer and antioxidant activities of n-hexane and methylene chloride extracts of Senna italica. J Appl Pharm Sci. 2017;7:023–32.
  63. Silhavy TJ, Kahne D, Walker S. The bacterial cell envelope. Cold Spring Harbor Perspect Biol. 2010;2:a000414.
  64. Breijyeh Z, Jubeh B, Karaman R. Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it. Molecules. 2020;25:1340.
  65. Huang W, Wang Y, Tian W, Cui X, Tu P, Li J, et al. Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants. Antibiotics. 2022;11:1380.
  66. Nishina A, Kubota K, Osawa T. Antimicrobial components, trachrysone and 2-methoxystypandrone, in Rumex japonicus Houtt. J Agric Food Chem. 1993;41:1772–5.
Language: English
Submitted on: Nov 23, 2024
Accepted on: Apr 30, 2025
Published on: Jun 20, 2025
Published by: Sciendo
In partnership with: Paradigm Publishing Services

© 2025 Rasha M. Alzayed, Meaad F. Alaida, Sondos A. Alhajouj, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 License.