Chemical profile of Senna italica and Senna velutina seed and their pharmacological properties

Figures & Tables

Peak	Retention time (min)	Area (Ab*s)	Area%	Hit name	Molecular formula	Molecular weight (amu)
1	7.766	631,469	8.11	Cyclododecyne	C₁₂H₂₀	164.157
2	11.112	397,355	5.11	Benzofuran, 2,3-dihydro-	C₈H₈O	120.058
3	15.147	489,738	6.29	l-Mannose, 6-deoxy-	C₆H₁₂O₅	164.068
4	19.119	271,125	3.48	‘Catechin	C₁₅H₁₄O₆	194.08
5	19.67	710,840	9.13	Luteolin	C₁₅H₁₀O₆	270.256
6	20.014	368,308	4.73	n-Hexadecanoic acid	C₁₆H₃₂O₂	256.24
7	21.409	908,989	11.68	2-Pentadecanone, 6,10,14-trimethyl-	C₁₈H₃₆O	268.277
8	21.74	2,350,092	30.21	2-Methoxystypandrone	C₁₄H₁₂O₅	260.24
9	22.691	315,893	4.06	9,12-Octadecadienoic acid (Z,Z)-	C₁₈H₃₂O₂	280.24
10	24.217	139,704	1.79	Kaempferol 3-O-rutinoside	C₂₇H₃₀O₁₅	266.225
11	24.311	259,712	3.33	cis,cis-7,10,-Hexadecadienal	C₁₆H₂₈O	236.214
12	25.093	622,846	8.01	Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester	C₁₉H₃₈O₄	330.277
13	26.231	311,334	4.01	9-Octadecenoic acid (Z)-, 2-hydroxyethyl ester	C₂₀H₃₈O₃	326.282

Peak	Retention time (min)	Area (Ab*s)	Area%	Hit name	Molecular formula	Molecular weight (amu)
1	18.719	633,215	6.04	Bicyclo[3.1.1]heptane, 2,6,6-trimethyl-, [1R-(1.alpha., 2.beta., 5.alpha.)]-	C₁₀H₁₈	138.141
2	18.825	134,340	1.28	2-Pentadecanone, 6,10,14-trimethyl-	C₁₈H₃₆O	268.277
3	18.994	117,647	1.12	3-Eicosyne	C₂₀H₃₈	278.297
4	19.188	246,133	2.34	3,7,11,15-Tetramethyl-2-hexadecen-1-ol	C₂₀H₄₀O	296.308
5	19.67	707,885	6.75	Hexadecanoic acid, methyl ester	C₁₇H₃₄O₂	270.256
6	20.126	3,402,460	32.48	n-Hexadecanoic acid	C₁₆H₃₂O₂	256.24
7	21.421	974,978	9.30	7,10,13-Hexadecatrienoic acid, methyl ester	C₁₇H₂₈O₂	264.209
8	21.527	973,232	9.29	1-Hexadecen-3-ol, 3,5,11,15-tetramethyl-	C₂₀H₄₀O	296.308
9	21.878	1,952,413	18.63	9,12,15-Octadecatrienoic acid, (Z,Z,Z)-	C₁₈H₃₀O₂	278.225
10	23.723	495,935	4.73	Cyclododecyne	C₁₂H₂₀	164.157
11	25.049	511,866	4.88	Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester	C₁₉H₃₈O₄	330.277
12	27.27	325,433	3.10	Squalene	C₃₀H₅₀	410.391

Bacterium/dilution	Positive control	1,000 μg/mL	500 μg/mL	250 μg/mL	125 μg/mL	MIC (μg/mL)	MBC (μg/mL)
S. aureus	31 ± 0.00	20 ± 0.00*	18 ± 0.00*	14 ± 0.00*	13 ± 0.00*	31.25 ± 0.00	62.5 ± 0.00
S. epidermidis	33 ± 0.00	21 ± 0.00*	17 ± 0.00*	12 ± 0.00*	10 ± 0.00*	15.62 ± 0.00	31.25 ± 0.00
B. subtilis	29 ± 0.00	20 ± 0.00*	18 ± 0.00*	11 ± 0.00*	9 ± 0.00*	15.62 ± 0.00	31.25 ± 0.00
E. coli	30 ± 0.00	24 ± 0.00*	18 ± 0.00*	12 ± 0.00*	10 ± 0.00*	31.25 ± 0.00	62.5 ± 0.00
K. pneumoniae	29 ± 0.00	23 ± 0.00*	20 ± 0.00*	14 ± 0.00*	11 ± 10.00*	31.25 ± 0.00	62.5 ± 0.00
P. aeruginosa	18 ± 0.00	17 ± 0.00	11 ± 0.00*	9 ± 0.00*	8 ± 0.00*	62.5 ± 0.00	125 ± 0.00

Bacterium/dilution	Positive control	1,000 μg/mL	500 μg/mL	250 μg/mL	125 μg/mL	MIC (μg/mL)	MBC (μg/mL)
S. aureus	31 ± 0.00	21 ± 0.00*	18 ± 0.00*	16 ± 0.00*	14 ± 0.00*	15.62 ± 0.00	31.25 ± 0.00
S. epidermidis	33 ± 0.00	24 ± 0.00*	20 ± 0.00*	17 ± 0.00*	14 ± 0.00*	7.81 ± 0.00	15.62 ± 0.00
B. subtilis	29 ± 0.00	22 ± 0.00*	18 ± 0.00*	11 ± 0.00*	9 ± 0.00*	15.62 ± 0.00	31.25 ± 0.00
E. coli	30 ± 0.00	23 ± 0.00*	18 ± 0.00*	10 ± 0.00*	8 ± 0.00*	31.25 ± 0.00	62.5 ± 0.00
K. pneumoniae	29 ± 0.00	15 ± 0.00*	11 ± 0.00*	9 ± 0.00*	7 ± 10.00	31.25 ± 0.00	62.5 ± 0.00
P. aeruginosa	18 ± 0.00	22 ± 0.00*	19 ± 0.00*	15 ± 0.00*	10 ± 0.00*	15.62 ± 0.00	31.25 ± 0.00