Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

A. Csanova; D. Jezova

doi:10.1515/afpuc-2016-0009

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Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

European Pharmaceutical Journal

Volume 63 (2016): Issue 1 (September 2016)

By: A. Csanova and D. Jezova

Open Access

|Nov 2016

Abstract

The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites.

References

[1] Connor TJ, Starr N, O’Sullivan JB, Harkin A. Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFNgamma? Neurosci Lett. 2008;441:29-34.10.1016/j.neulet.2008.06.00718584961
Search in Google Scholar Back to article
[2] Corona AW, Huang Y, O’Connor JC, Dantzer R, Kelley KW, Popovich PG, Godbout JP. Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J Neuroinflammation. 2010;7:93.10.1186/1742-2094-7-93301841621167054
Search in Google Scholar Back to article
[3] Daneva T, Spinedi E, Hadid R, Jacquier MC, Giacomini M, Gaillard RC. Transient sex-related changes in the mice hypothalamopituitary- adrenal (HPA) axis during the acute phase of the inflammatory process. Mediators Inflamm. 1993;2:123-127.10.1155/S0962935193000183236539818475514
Search in Google Scholar Back to article
[4] Franklin M, Hlavacova N, Babic S, Pokusa M, Bermudez I, Jezova D. Aldosterone Signals the Onset of Depressive Behaviour in a Female Rat Model of Depression along with SSRI Treatment Resistance. Neuroendocrinology. 2015;102:274-287. 10.1159/00043115225968351
Search in Google Scholar Back to article
[5] Jezova D, Jurankova E, Mosnarova A, Kriska M, Skultetyova I. Neuroendocrine response during stress with relation to gender differences. Acta Neurobiol Exp (Wars). 1996;56:779-785.10.55782/ane-1996-1183
Search in Google Scholar Back to article
[6] Kubesova A, Tejkalova H, Syslova K, Kacer P, Vondrousova J, Tyls F, Fujakova M, Palenicek T, Horacek J. Biochemical, Histopathological and Morphological Profiling of a Rat Model of Early Immune Stimulation: Relation to Psychopathology. PLoS One. 2015;10:e0115439.10.1371/journal.pone.0115439430008125602957
Search in Google Scholar Back to article
[7] Parrott JM, O’Connor JC. Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology. Front Psychiatry. 2015;6:116.10.3389/fpsyt.2015.00116454213426347662
Search in Google Scholar Back to article
[8] Theofylaktopoulou D, Midttun O, Ulvik A, Ueland PM, Tell GS, Vollset SE, Nygard O, Eussen SJ. A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. Clin Exp Immunol. 2013;173:121-130. 10.1111/cei.12092369454223607723
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.1515/afpuc-2016-0009 | Journal eISSN: 2453-6725

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Language: English

Page range: 20 - 22

Submitted on: Aug 1, 2016

Accepted on: Aug 5, 2016

Published on: Nov 23, 2016

Published by: Comenius University in Bratislava, Faculty of Pharmacy

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

Immune challenge,

Kynurenine-3-monooxygenase,

Gender

Related subjects:

Pharmacy,

Pharmacy, other

© 2016 A. Csanova, D. Jezova, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 63 (2016): Issue 1 (September 2016)