Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity
By: L. Slovák, S. Poništ, V. Kuncírová, D. Mihalová, T. Fedorova and K. Bauerová
Abstract
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites.
DOI: https://doi.org/10.1515/afpuc-2016-0001 | Journal eISSN: 2453-6725
Language: English
Page range: 16 - 19
Submitted on: Jun 24, 2016
Accepted on: Jul 20, 2016
Published on: Nov 23, 2016
Published by: Comenius University in Bratislava, Faculty of Pharmacy
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
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© 2016 L. Slovák, S. Poništ, V. Kuncírová, D. Mihalová, T. Fedorova, K. Bauerová, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.