Synthesis and Characterization of Poly(Acrylic Acid)/Organo-Modified Nanohydroxyapatite Nanocomposites: Thermal, Optical and Biocompatibility Properties

Diken, M. E.; Doğan, S.; Turhan, Y.; Doğan, M.

doi:10.1515/adms-2017-0041

Abstract

The aim of this study was to investigate the structural, thermal, optical and biocompatibility properties of poly(acrylic acid)(PAA)/organo-modified nanohydroxyapatite (OM-nHAp) nanocomposites synthesized by solvent intercalation method. The characterization of PAA/OM-nHAp nanocomposites was made by different techniques. SEM and TEM results showed that OM-nHAp particles were dispersed in the nanoscale into PAA matrix and that they were uniformly distributed within film. Glass transition temperature of PAA increased with OM-nHAp content. Ultraviolet (UV) absorbance experiments showed that PAA had a higher UV transmission than its nanocomposites. The biocompatibility of nanocomposites was also examined in simulated body fluid.

References

1. Dutta, J., Hofmann, H. in: H.S. Nalwa (Ed.), in: Encyclopedia of Nanoscience and Nanotechnology, vol. 9, American Scientific Publishers, (2004), 617.
Search in Google Scholar Back to article
2. Sadat-Shojai, M., Khorasani, M.T., Jamshidi, A., Irani, S. Nano-hydroxyapatite reinforced polyhydroxybutyrate composites: A comprehensive study on the structural and in vitro biological properties. Materials Science and Engineering C 33, (2013), 2776–2787.10.1016/j.msec.2013.02.04123623096
Search in Google Scholar Back to article
3. Pon-On, W., Charoenphandhu, N., Tang, I.M., Teerapornpuntakit, J., Thongbunchoo, J., Krishnamra, N. Biocomposite of hydroxyapatite-titania rods (HApTiR): Physical properties and in vitro study. Materials Science and Engineering C 33, (2013), 251–258.10.1016/j.msec.2012.08.03725428069
Search in Google Scholar Back to article
4. Hamad, M., Carretti E., Dei L., Baglioni P., Aqueous polyacrylic acid based gels: physicochemical properties and application the growth of Whitlockite. JCG. 79 (1986), 192-197.
Search in Google Scholar Back to article
5. Batin, G., Popa, C., Brânduşan, L., Vida-Simiti, I. Mechanical properties of Ti/HA functionally graded materials for hard tissue replacement. Powder Metallurgy Progress, 11(3-4) (2011).
Search in Google Scholar Back to article
6. Silva, V.V., Lameiras, F.S., Domingues, R.Z. Microstructural and mechanical study of zirconia-hydroxyapatite (ZH) composite ceramics for biomedical applications. Composites Science and Technology. 61 (2001), 301-310.
Search in Google Scholar Back to article
7. Bertoni, E., Bigi, A., Falini, G., Panzavolta, S., Roveri, N. Hydroxyapatite/polyacrylic acid nanocrystals. J. Mater. Chem. 9 (1999), 779–782.
Search in Google Scholar Back to article
8. Wosek, J. Fabrication of composite polyurethane/hydroxyapatite scaffolds using solvent-casting salt leaching technique. Advances in Materials Science, 15(1) (2015), 14-20.10.1515/adms-2015-0003
Search in Google Scholar Back to article
9. Yilmaz, B., Doğan, S., Kasımoğulları, S.Ç. Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method. International Journal of Polymeric Materials and Polymeric Biomaterials. 67(6) 2018 351-360.10.1080/00914037.2017.1331349
Search in Google Scholar Back to article
10. Diken, M.E., Doğan, S., Turhan, Y., Doğan, M. Biological properties of PMMA/nHAp and PMMA/3-APT-nHAp nanocomposites. International Journal of Polymeric Materials and Polymeric Biomaterials. 67(13) (2018), 783–791.10.1080/00914037.2017.1378885
Search in Google Scholar Back to article
11. Yoshida, A., Miyazaki, T., Ishida, E., Ashizuka, M. Preparation of bioactive chitosan-hydroxyapatite nanocomposites for bone repair through mechanochemical reaction. Materials Transactions. 45(4) (2004), 994-998.10.2320/matertrans.45.994
Search in Google Scholar Back to article
12. Khan, A.S., Wong, F.S.L., McKay, I.J., Whiley, R.A., Rehman, I.U. Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite. J. Appl. Polym. Sci. 130 (2013), 439-447.
Search in Google Scholar Back to article
13. El-Bahy, G.S., Abdelrazek, E.M., Allam, M.A., Hezma, A.M. Characterization of in situ prepared nano-hydroxyapatite/polyacrylic acid (HAp/PAAc) biocomposites. Journal of Applied Polymer Science. 122 (2011), 3270–3276.
Search in Google Scholar Back to article
14. Darder, M., Colilla, M., Ruiz-Hitzky, E. Biopolymer−Clay Nanocomposites Based on Chitosan Intercalated in Montmorillonite. Chem. Mater. 15(20) (2003), 3774–3780.10.1021/cm0343047
Search in Google Scholar Back to article
15. Wang, S.F., Shen, L., Zhang, W-D., Tong, Y-J. Preparation and mechanical properties of chitosan/carbon nanotubes composites. Biomacromolecules, 6(6) (2005), 3067–3072.10.1021/bm050378v16283728
Search in Google Scholar Back to article
16. Turhan, Y., Turan, P., Doğan, M., Alkan, M., Namli, H. and Demirbaş, Ö. Characterization and adsorption properties of chemically modified sepiolite. Industrial & Engineering Chemistry Research. 47(6) (2008), 1883-1895.10.1021/ie070506r
Search in Google Scholar Back to article
17. Doğan, M., Turhan, Y., Alkan, M., Namli, H., Turan, P. and Demirbaş, Ö. Functionalized sepiolite for heavy metal ions adsorption. Desalination. 230(1-3) (2008), 248-268.10.1016/j.desal.2007.11.029
Search in Google Scholar Back to article
18. Kızılduman, B.K., Alkan, M., Doğan, M., Turhan, Y. Al-pillared-montmorillonite (AlPMt)/poly(methyl methacrylate)(PMMA) nanocomposıtes: the effects of solvent types and synthesıs methods. Advances in Materials Science, 17(3) (2017), 5-23.10.1515/adms-2017-0012
Search in Google Scholar Back to article
19. Turhan, Y., Doğan, M. and Alkan, M. Poly(vinyl chloride)/kaolinite nanocomposites: Characterization, Thermal and Optical Properties. Industrial & Engineering Chemistry Research. 49 (2010), 1503-1513.10.1021/ie901384x
Search in Google Scholar Back to article
20. Turhan, Y., Alp, Z.G., Alkan, M., Doğan, M., Preparation and characterization of poly(vinylalcohol)/modified bentonite nanocomposites. Microporous and Mesoporous Materials. 174 (2013), 144-153.10.1016/j.micromeso.2013.03.002
Search in Google Scholar Back to article
21. Belanger, M, Marois, Y. Hemocompatibility, biocompatibility, inflammatory and in vivo studies of primary reference materials low-density polyethylene and polydimethylsiloxane: a review. Journal of Biomedical Materials Research. 58(5) (2001), 467–477.10.1002/jbm.104311505420
Search in Google Scholar Back to article
22. Arsad, S.M., Lee, P.M., Hunk, L.K. Synthesis and characterization of hydroxyapatite nanoparticles and β-TCP particles. International Conference on Biotechnology and Food Science. 7 (2011), 184-188.
Search in Google Scholar Back to article
23. Hojjati, B., Sui, R., Charpentier, P.A. Synthesis of TiO₂/PAA nanocomposite by RAFT polymerization. Polymer. 48 (2007), 5850-5858.
Search in Google Scholar Back to article
24. Dubinsky, S., Grader, G.S., Shter, G.E., Silverstein, M.S. Thermal degradation of poly(acrylic acid) containing copper nitrate. Polymer Degradation and Stability. 86 (2004), 171-178.
Search in Google Scholar Back to article
25. Turhan, Y., Doğan, M., Alkan, M. Characterization and some properties of poly(vinyl chloride)/sepiolite nanocomposites. Advances in Polymer Technology. 32(1) (2013) E65-E82.10.1002/adv.20271
Search in Google Scholar Back to article
26. Corcione, C.E., Frigione, M. Characterization of nanocomposites by thermal analysis. Materials. 5 (2012), 2960-2980.
Search in Google Scholar Back to article
27. Fuente, J.L., Wilhelm, M., Spiess, H.W., Madruga, E.L., Fernandez-Garcia, M. Cerrada, M.L. Thermal, morphological and rheological characterization of poly(acrylic acid-g-styrene) amphiphilic graft copolymers. Polymer. 46 (2005), 4544–4553.
Search in Google Scholar Back to article
28. McGaugh, M.C., Kottle, S. The thermal degradation of poly(acrylic acid). Journal of Polymer Science Part B: Polymer Letters. Journal of Polymer Science Part B: Polymer Letters. 5(9) (1967), 817–820.10.1002/pol.1967.110050916
Search in Google Scholar Back to article
29. Beyli, P.T., Doğan, M., Gündüz, Z., Alkan, M., Turhan, Y. Synthesis, characterization and their antimicrobial activities of boron oxide/poly(acrylic acid) nanocomposites: thermal and antimicrobial properties. Advances in Materials Science, 18(1) (2018), 28-36.10.1515/adms-2017-0025
Search in Google Scholar Back to article
30. Çakir, R. The development of a new culture model to study the toxicity of polymers. MSc Thesis. Yildiz Technical University, Istanbul-Turkey, 2008.
Search in Google Scholar Back to article

Synthesis and Characterization of Poly(Acrylic Acid)/Organo-Modified Nanohydroxyapatite Nanocomposites: Thermal, Optical and Biocompatibility Properties

Abstract

Paradigm

My account