Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits

Franc, Aleš; Kurhajec, Slavomir; Pavloková, Sylvie; Sabadková, Dana; Muselík, Jan

doi:10.1515/acph-2017-0019

Abstract

The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel^® PH 101 and Avicel^® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel^® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH).

References

1. B. Hennig, A. S. Ettinger, R. J. Jandacek, S. Koo, C. McClain, H. Seifried, A. Silverstone, B. Watkins and W. A. Suk, Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases, Environ. Health Perspect. 115 (2007) 493-495; DOI: 10.1289/ehp.9549.10.1289/ehp.9549
Search in Google Scholar Back to article
2. V. Katalinic, M. Milos, T. Kulisic and M. Jukic, Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols, Food Chem. 94 (2006) 550-557; DOI: 10.1016/j.foodchem. 2004.12.004.
Search in Google Scholar Back to article
3. İ. Gülçin, Ş. Beydemir, G. Şat and Ö. İ. Küfrevioğlu, Evaluation of antioxidant activity of cornelian cherry (Cornus mas L.), Acta Aliment. 34 (2005) 193-202; DOI: 10.1556/aalim.34.2005.2.13.10.1556/AAlim.34.2005.2.13
Search in Google Scholar Back to article
4. L. J. McGaw, A. K. Jage and J. Van Staden, Antibacterial, anthelmintic and anti-amoebic activity in South African medicinal plants, J. Ethnopharmacol. 72 (2000) 247-263; DOI: 10.1016/s0378-8741(00)00269-5.10.1016/S0378-8741(00)00269-5
Search in Google Scholar Back to article
5. B. Jayaprakasam, L. K. Olson, R. E. Schutzki, M. H. Tai and M. G. Nair, Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas), J. Agric. Food Chem. 54 (2006) 243-248; DOI: 10.1021/jf0520342.10.1021/jf052034216390206
Search in Google Scholar Back to article
6. S. Asgary, R. Kelishadi, M. Rafieian-Kopaei, S. Najafi, M. Najafi and A. Sahebkar, Investigation of the lipid-modifying and antiinflammatory effects of Cornus mas L. supplementation on dyslipidemic children and adolescents, Pediatr. Cardiol. 34 (2013) 1729-1735; DOI: 10.1007/s00246-013-0693-5.10.1007/s00246-013-0693-523625305
Search in Google Scholar Back to article
7. G. E. Pantelidis, M. Vasilakakis, G. A. Manganaris and G. Diamantidis, Antioxidant capacity, phenol, anthocyanin and ascorbic acid contents in raspberries, blackberries, red currants, gooseberries and Cornelian cherries, Food Chem. 102 (2007) 777-783; DOI: 10.1016/j.foodchem.2006.06.021.10.1016/j.foodchem.2006.06.021
Search in Google Scholar Back to article
8. S. Kurhajec, A. Franc, P. Doležel and D. Sabadková, Quality by design approach: antioxidant activity of the tablets containing cornelian cherry fruits in relation to their composition and physical properties, Pharm. Dev. Technol. Epub (2016); 1-8; DOI: 0.3109/10837450.2015.1135345.
Search in Google Scholar Back to article
9. R. O. B. Wijesekera, The Medicinal Plant Industry, CRC Press, Boca Raton 1991.
Search in Google Scholar Back to article
10. T. Koyuncu, İ. Tosun and Y. Pinar, Drying characteristics and heat energy requirement of cornelian cherry fruits (Cornus mas L.), J. Food Eng. 78 (2007) 735-739; DOI: 10.1016/j.jfoodeng.2005.09.035.10.1016/j.jfoodeng.2005.09.035
Search in Google Scholar Back to article
11. L. Gallo, M. V. Ramírez-Rigo, J. Piña, S. Palma, D. Allemandi and V. Bucalá, Valeriana officinalis dry plant extract for direct compression: preparation and characterization, Sci. Pharm. 80 (2012) 1013; DOI: 10.3797/scipharm.1206-05.10.3797/scipharm.1206-05352805823264947
Search in Google Scholar Back to article
12. European Pharmacopoeia, 8th ed., Council of Europe, Strasbourg 2013; DOI: 0.1007/978-3-211-89836-9_515.
Search in Google Scholar Back to article
13. The United States Pharmacopeia 39, NF 34, U.S. Pharmacopeial Convention, Rockville, MD, 2016.
Search in Google Scholar Back to article
14. R Core Team, A Language and Environment for Statistical Computing (R Foundation for Statistical Computing. R foundation for statistical computing 2012; https://www.r-project.org; access date June 30 2016.
Search in Google Scholar Back to article
15. S. Kalia, Cryogenic processing: a study of materials at low temperatures, J. Low Temp. Phys. 158 (2010) 934-945; DOI: 10.1007/s10909-009-0058-x.10.1007/s10909-009-0058-x
Search in Google Scholar Back to article
16. E. Doelker, D. Massuelle, F. Veuillez and P. Humbert-Droz, Morphological, packing, flow and tableting properties of new Avicel types, Drug Dev. Ind. Pharm. 21 (1995) 643-661; DOI: 10.3109/03639049509048132.10.3109/03639049509048132
Search in Google Scholar Back to article
17. M. K. Taylor, J. Ginsburg, A. J. Hickey and F. Gheyas, Composite method to quantify powder flow as a screening method in early tablet or capsule formulation development, AAPS PharmSciTech 1 (2000) 20-30; DOI: 10.1208/pt010318.10.1208/pt010318275034614727904
Search in Google Scholar Back to article
18. K. Seppälä, J. Heinämäki, J. Hatara, L. Seppälä and J. Yliruusi, Development of a new method to get reliable powder flow characteristics using only 1 to 2 g of powder, AAPS PharmSciTech 11 (2010) 402-408; DOI: 10.1208/s12249-010-9397-9.10.1208/s12249-010-9397-9285046720238189
Search in Google Scholar Back to article
19. R. B. Shah, M. A. Tawakkul and M. A. Khan, Comparative evaluation of flow for pharmaceutical powders and granules, AAPS PharmSciTech 9 (2008) 250-258; DOI: 10.1208/s12249-008-9046-8.10.1208/s12249-008-9046-8297691118446489
Search in Google Scholar Back to article
20. E. Lahdenpää, M. Niskanen and J. Yliruusi, Study of some essential physical characteristics of three Avicel® PH grades using a mixture design, Eur. J. Pharm. Biopharm. 42 (1996) 177-182.
Search in Google Scholar Back to article
21. J. K. Prescott and R. Hoodfeld, Maintaining product uniformity and uninterrupted flow to directcompression tableting presses, Pharm. Technol. 18 (1994) 98-98.
Search in Google Scholar Back to article
22. C. Reimann, P. Filzmoser, R. Garret and R. Dutter, Statistical data analysis explained: applied environmental statistics with R, John Wiley & Sons, Chichester 2008; DOI: 10.1002/9780470987605.10.1002/9780470987605
Search in Google Scholar Back to article
23. R. Elbaum, S. Gorb and P. Fratzl, Structures in the cell wall that enable hygroscopic movement of wheat awns, J. Struct. Biol. 164 (2008) 101-107; DOI: 10.1016/j.jsb.2008.06.008.10.1016/j.jsb.2008.06.00818625323
Search in Google Scholar Back to article
24. Y. E. Zhang and J. B. Schwartz, Effect of diluents on tablet integrity and controlled drug release, Drug Dev. Ind. Pharm. 26 (2000) 761-765; DOI: 10.1081/DDC-100101295.10.1081/DDC-100101295
Search in Google Scholar Back to article
25. S. Dawoodbhai and C. T. Rhodes, The effect of moisture on powder flow and on compaction and physical stability of tablets, Drug Dev. Ind. Pharm. 15 (1989) 1577-1600.10.3109/03639048909052504
Search in Google Scholar Back to article
26. Y. Bi, H. Sunada, Y. Yonezawa, K. Danjo, A. Otsuka and K. Iida, Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity, Chem. Pharm. Bull. 44 (1996) 2121-2127.10.1248/cpb.44.21218945778
Search in Google Scholar Back to article
27. WHO, Stability testing of active pharmaceutical ingredients and finished pharmaceutical products. WHO Technical Report Series. 2009; http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q1F/Stability_Guideline_WHO.pdf; access date June 5, 2016.
Search in Google Scholar Back to article
28. J. Vercruysse, A. Burggraeve, M. Fonteyne, P. Cappuyns, U. Delaet, I. Van Assche, T. De Beerc, J. P. Remona and C. Vervaet, Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation, Int. J. Pharm. 479 (2015) 171-180; DOI: 10.1016/j.ijpharm.2014.12.071.10.1016/j.ijpharm.2014.12.07125562758
Search in Google Scholar Back to article

Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits

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