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The therapeutic agents that target ATP-sensitive potassium channels Cover

The therapeutic agents that target ATP-sensitive potassium channels

Acta Pharmaceutica
Volume 66 (2016): Issue 1 (March 2016)
By: Hussein N. Rubaiy  
Open Access
|Mar 2016

References

  1. 1. B. Hille, Ion Channels of Excitable Membranes, Sinauer Associates, Sunderland 2001, p. 814.
    Search in Google Scholar
  2. 2. S. Choe, Potassium channel structures, Nat. Rev. Neurosci. 3 (2002) 115–121; DOI: 10.1038/nrn727.10.1038/nrn727
    Search in Google Scholar
  3. 3. C. C. Shieh, M. Coghlan, J. P. Sullivan and M. Gopalakrishnan, Potassium channels: molecular defects, diseases, and therapeutic opportunities, Pharmacol. Rev. 52 (2000) 557–594.
    Search in Google Scholar
  4. 4. C. A. Doupnik, N. Davidson and H. A. Lester, The inward rectifier potassium channel family, Curr. Opin. Neurobiol. 5 (1995) 268–277; DOI: 10.1016/0959-4388(95)80038-7.10.1016/0959-4388(95)80038-7
    Search in Google Scholar
  5. 5. C. G. Nichols and A. N. Lopatin, Inward rectifier potassium channels, Annu. Rev. Physiol. 59 (1997) 171–191; DOI: 10.1146/annurev.physiol.59.1.171.10.1146/annurev.physiol.59.1.171
    Search in Google Scholar
  6. 6. D. Bichet, F. A. Haass and L. Y. Jan, Merging functional studies with structures of inward-rectifier K(+) channels, Nat. Rev. Neurosci. 4 (2003) 957–967; DOI: 10.1038/nrn1244.10.1038/nrn1244
    Search in Google Scholar
  7. 7. D. E. Logothetis, D. Lupyan and A. Rosenhouse-Dantsker, Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding, J. Physiol. 582 (2007) 953–965; DOI: 10.1113/jphysiol.2007.133157.10.1113/jphysiol.2007.133157
    Search in Google Scholar
  8. 8. L. H. Xie, S. A. John, B. Ribalet and J. N. Weiss, Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands, Prog. Biophys. Mol. Biol. 94 (2007) 320–335; DOI: 10.1016/j.pbiomolbio.2006.04.001.10.1016/j.pbiomolbio.2006.04.001
    Search in Google Scholar
  9. 9. A. Noma, ATP-regulated K+ channels in cardiac muscle, Nature305 (1983) 147–148; DOI: 10.1038/305147a0.10.1038/305147a0
    Search in Google Scholar
  10. 10. D. L. Cook and C. N. Hales, Intracellular ATP directly blocks K+ channels in pancreatic B-cells, Nature311 (1984) 271–273; DOI: 10.1038/311271a0.10.1038/311271a0
    Search in Google Scholar
  11. 11. A. E. Spruce, N. B. Standen and P. R. Stanfield, Voltage-dependent ATP-sensitive potassium channels of skeletal muscle membrane, Nature316 (1985) 736–738; DOI: 10.1038/316736a0.10.1038/316736a0
    Search in Google Scholar
  12. 12. S. J. Ashcroft and F. M. Ashcroft, Properties and functions of ATP-sensitive K-channels, Cell. Signal. 2 (1990) 197–214; DOI 10.1016/0898-6568(90)90048-F.10.1016/0898-6568(90)90048-F
    Search in Google Scholar
  13. 13. N. B. Standen, J. M. Quayle, N. W. Davies, J. E. Brayden, Y. Huang and M. T. Nelson, Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle, Science245 (1989) 177–180; DOI: 10.1126/science.2501869.10.1126/science.2501869
    Search in Google Scholar
  14. 14. L. Aguilar-Bryan and J. Bryan, Molecular biology of adenosine triphosphate-sensitive potassium channels, Endocr. Rev. 20 (1999) 101–135; DOI: 10.1210/edrv.20.2.0361.10.1210/edrv.20.2.0361
    Search in Google Scholar
  15. 15. G. E. Billman, The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapy, Pharmacol. Ther. 120 (2008) 54–70; DOI: 10.1016/j.pharmthera.2008.07.004.10.1016/j.pharmthera.2008.07.004
    Search in Google Scholar
  16. 16. S. Isomoto and Y. Kurachi, [Molecular and biophysical aspects of potassium channels], Nihon Rinsho. (Jpn. J. Clin. Med.) 54 (1996) 660–666.
    Search in Google Scholar
  17. 17. J. Bryan and L. Aguilar-Bryan, Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channels, Biochim. Biophys. Acta1461 (1999) 285–303; DOI: 10.1016/S0005-2736(99)00164-9.10.1016/S0005-2736(99)00164-9
    Search in Google Scholar
  18. 18. N. Inagaki and S. Seino, ATP-sensitive potassium channels: structures, functions, and pathophysiology, Jpn. J. Physiol. 48 (1998) 397–412; DOI: 10.2170/jjphysiol.48.397.10.2170/jjphysiol.48.39710021494
    Search in Google Scholar
  19. 19. M. Matsuo, K. Tanabe, N. Kioka, T. Amachi and K. Ueda, Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B, J. Biol. Chem. 275 (2000) 28757–28763; DOI: 10.1074/jbc.M004818200.10.1074/jbc.M00481820010893240
    Search in Google Scholar
  20. 20. M. Dean, A. Rzhetsky and R. Allikmets, The human ATP-binding cassette (ABC) transporter superfamily, Genome Res. 11 (2001) 1156–1166; DOI: 10.1101/gr.184901.10.1101/gr.18490111435397
    Search in Google Scholar
  21. 21. L. Aguilar-Bryan, J. P. Clement IV, G. Gonzalez, K. Kunjilwar, A. Babenko and J. Bryan, Toward understanding the assembly and structure of KATP channels, Physiol. Rev. 78 (1998) 227–245.10.1152/physrev.1998.78.1.2279457174
    Search in Google Scholar
  22. 22. B. G. Gabrielsson, A. C. Karlsson, M. Lonn, L. E. Olofsson, J. M. Johansson, J. S. Torgerson, L. Sjostrom, B. Carlsson, S. Eden and L. M. Carlsson, Molecular characterization of a local sulfonylurea system in human adipose tissue, Mol. Cell. Biochem. 258 (2004) 65–71; DOI: 10.1023/B:MCBI.0000012837.11847.c8.10.1023/B:MCBI.0000012837.11847.c8
    Search in Google Scholar
  23. 23. C. F. Higgins, ABC transporters: physiology, structure and mechanism-an overview, Res. Microbiol. 152 (2001) 205–210.
    Search in Google Scholar
  24. 24. J. E. Walker, M. Saraste, M. J. Runswick and N. J. Gay, Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold, EMBO J. 1 (1982) 945–951.10.1002/j.1460-2075.1982.tb01276.x5531406329717
    Search in Google Scholar
  25. 25. R. Mannhold, KATP channel openers: structure-activity relationships and therapeutic potential, Med. Res. Rev. 24 (2004) 213–266; DOI: 10.1002/med.10060.10.1002/med.10060
    Search in Google Scholar
  26. 26. J. P. Clement IV, K. Kunjilwar, G. Gonzalez, M. Schwanstecher, U. Panten, L. Aguilar-Bryan and J. Bryan, Association and stoichiometry of K(ATP) channel subunits, Neuron18 (1997) 827–838; DOI: 10.1016/S0896-6273(00)80321-9.10.1016/S0896-6273(00)80321-9
    Search in Google Scholar
  27. 27. D. Enkvetchakul, G. Loussouarn, E. Makhina and C. G. Nichols, ATP interaction with the open state of the K(ATP) channel, Biophys. J. 80 (2001) 719–728; DOI: 10.1016/S0006-3495(01)76051-1.10.1016/S0006-3495(01)76051-1
    Search in Google Scholar
  28. 28. M. A. Burke, R. K. Mutharasan and H. Ardehali, The sulfonylurea receptor, an atypical ATP-bin ding cassette protein, and its regulation of the KATP channel, Circ. Res. 102 (2008) 164–176; DOI: 10.1161/CIRCRESAHA.107.165324.10.1161/CIRCRESAHA.107.165324
    Search in Google Scholar
  29. 29. F. M. Ashcroft and F. M. Gribble, Correlating structure and function in ATP-sensitive K+ channels, Trends Neurosci. 21 (1998) 288–294; DOI: 10.1016/S0166-2236(98)01225-9.10.1016/S0166-2236(98)01225-9
    Search in Google Scholar
  30. 30. S. Seino, Physiology and pathophysiology of K(ATP) channels in the pancreas and cardiovascular system: a review, J. Diabetes Compl. 17 (2003) 2–5; DOI: 10.1016/S1056-8727(02)00274-X.10.1016/S1056-8727(02)00274-X
    Search in Google Scholar
  31. 31. S. Sattiraju, S. Reyes, G. C. Kane and A. Terzic, K(ATP) channel pharmacogenomics: from bench to bedside, Clin. Pharmacol. Ther. 83 (2008) 354–357; DOI: 10.1038/sj.clpt.6100378.10.1038/sj.clpt.6100378271988817957187
    Search in Google Scholar
  32. 32. K. Hussain and K. E. Cosgrove, From congenital hyperinsulinism to diabetes mellitus: the role of pancreatic beta-cell KATP channels, Pediatr. Diabetes6 (2005) 103–113; DOI: 10.1111/j.1399-543X.2005.00109.x.10.1111/j.1399-543X.2005.00109.x15963039
    Search in Google Scholar
  33. 33. N. Deutsch, T. S. Klitzner, S. T. Lamp and J. N. Weiss, Activation of cardiac ATP-sensitive K+ current during hypoxia: correlation with tissue ATP levels, Am. J. Physiol. 261 (1991) H671-6.
    Search in Google Scholar
  34. 34. Y. G. Kwak, S. K. Park, U. H. Kim, M. K. Han, J. S. Eun, K. P. Cho and S. W. Chae, Intracellular ADP-ribose inhibits ATP-sensitive K+ channels in rat ventricular myocytes, Am. J. Physiol. 271 (1996) C464-8.10.1152/ajpcell.1996.271.2.C4648769984
    Search in Google Scholar
  35. 35. H. Yokoshiki, M. Sunagawa, T. Seki and N. Sperelakis, ATP-sensitive K+ channels in pancreatic, cardiac, and vascular smooth muscle cells, Am. J. Physiol. 274 (1998) C25–C37.10.1152/ajpcell.1998.274.1.C259458709
    Search in Google Scholar
  36. 36. J. E. Brayden, Functional roles of KATP channels in vascular smooth muscle, Clin. Exp. Pharmacol. Physiol. 29 (2002) 312–316; DOI: 10.1046/j.1440-1681.2002.03650.x.10.1046/j.1440-1681.2002.03650.x
    Search in Google Scholar
  37. 37. M. Yamada, S. Isomoto, S. Matsumoto, C. Kondo, T. Shindo, Y. Horio and Y. Kurachi, Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel, J. Physiol. 499 (1997) 715–20; DOI: 10.1113/jphysiol.1997.sp021963.10.1113/jphysiol.1997.sp021963
    Search in Google Scholar
  38. 38. J. Roper and F. M. Ashcroft, Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones, Pflugers Arch. 430 (1995) 44–54; DOI: 10.1007/BF00373838.10.1007/BF00373838
    Search in Google Scholar
  39. 39. I. M. Stanford and M. G. Lacey, Electrophysiological investigation of adenosine trisphosphate-sensitive potassium channels in the rat substantia nigra pars reticulata, Neuroscience74 (1996) 499–509; DOI: 10.1016/0306-4522(96)00151-0.10.1016/0306-4522(96)00151-0
    Search in Google Scholar
  40. 40. M. L. Ashford, P. R. Boden and J. M. Treherne, Tolbutamide excites rat glucoreceptive ventromedial hypothalamic neurones by indirect inhibition of ATP-K+ channels, Br. J. Pharmacol. 101 (1990) 531–540; DOI: 10.1111/j.1476-5381.1990.tb14116.x.10.1111/j.1476-5381.1990.tb14116.x
    Search in Google Scholar
  41. 41. M. Chien, I. Morozova, S. Shi, H. Sheng, J. Chen, S. M. Gomez, G. Asamani, K. Hill, J. Nuara, M. Feder, J. Rineer, J. J. Greenberg, V. Steshenko, S. H. Park, B. Zhao, E. Teplitskaya, J. R. Edwards, S. Pampou, A. Georghiou, I. C. Chou, W. Iannuccilli, M. E. Ulz, D. H. Kim, A. Geringer-Sameth, C. Goldsberry, P. Morozov, S. G. Fischer, G. Segal, X. Qu, A. Rzhetsky, P. Zhang, E. Cayanis, P. J. De Jong, J. Ju, S. Kalachikov, H. A. Shuman and J. J. Russo, The genomic sequence of the accidental pathogen Legionella pneumophila, Science305 (2004) 1966–1968; DOI: 10.1126/science.1099776.10.1126/science.1099776
    Search in Google Scholar
  42. 42. K. Yamada and N. Inagaki, ATP-sensitive K(+) channels in the brain: sensors of hypoxic conditions, News Physiol. Sci. 17 (2002) 127–30.
    Search in Google Scholar
  43. 43. N. W. Davies, Modulation of ATP-sensitive K+ channels in skeletal muscle by intracellular protons, Nature343 (1990) 375–377; DOI: 10.1038/343375a0.10.1038/343375a0
    Search in Google Scholar
  44. 44. J. J. Nielsen, M. Kristensen, Y. Hellsten, J. Bangsbo and C. Juel, Localization and function of ATP-sensitive potassium channels in human skeletal muscle, Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 (2003) R558-R63; DOI: 10.1152/ajpregu.00303.2002.10.1152/ajpregu.00303.2002
    Search in Google Scholar
  45. 45. S. M. Gopalakrishnan, C. Chen and M. F. Lokhandwala, Identification of alpha 1-adrenoceptor subtypes in rat renal proximal tubules, Eur. J. Pharmacol. 250 (1993) 469–472; DOI: 10.1016/0014-2999(93)90036-H.10.1016/0014-2999(93)90036-H
    Search in Google Scholar
  46. 46. A. P. Babenko, L. Aguilar-Bryan and J. Bryan, A view of sur/KIR6.X, KATP channels, Annu. Rev. Physiol. 60 (1998) 667–687; DOI: 10.1146/annurev.physiol.60.1.667.10.1146/annurev.physiol.60.1.6679558481
    Search in Google Scholar
  47. 47. S. Seino, ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies, Annu. Rev. Physiol. 61 (1999) 337–362; DOI: 10.1146/annurev.physiol.61.1.337.10.1146/annurev.physiol.61.1.337
    Search in Google Scholar
  48. 48. N. Inagaki, T. Gonoi, J. P. Clement IV, N. Namba, J. Inazawa, G. Gonzalez, L. Aguilar-Bryan, S. Seino and J. Bryan, Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor, Science270 (1995) 1166–1170; DOI: 10.1126/science.270.5239.1166.10.1126/science.270.5239.1166
    Search in Google Scholar
  49. 49. S. Isomoto, C. Kondo, M. Yamada, S. Matsumoto, O. Higashiguchi, Y. Horio, Y. Matsuzawa and Y. Kurachi, A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel, J. Biol. Chem. 271 (1996) 24321–24324; DOI: 10.1074/jbc.271.40.24321.10.1074/jbc.271.40.24321
    Search in Google Scholar
  50. 50. P. Proks, F. Reimann, N. Green, F. Gribble and F. Ashcroft, Sulfonylurea stimulation of insulin secretion, Diabetes51 (2002) S368–S376; DOI: 10.2337/diabetes.51.2007.S368.10.2337/diabetes.51.2007.S368
    Search in Google Scholar
  51. 51. F. M. Gribble and F. Reimann, Pharmacological modulation of K(ATP) channels, Biochem. Soc. Trans. 30 (2002) 333–339; DOI: 10.1042/bst0300333.10.1042/bst0300333
    Search in Google Scholar
  52. 52. T. Hamaguchi, T. Hirose, H. Asakawa, Y. Itoh, K. Kamado, K. Tokunaga, K. Tomita, H. Masuda, N. Watanabe and M. Namba, Efficacy of glimepiride in type 2 diabetic patients treated with glibenclamide, Diabetes Res. Clin. Pract. 66 (2004) S129–S132; DOI: 10.1016/j.diabres.2003.12.012.10.1016/j.diabres.2003.12.012
    Search in Google Scholar
  53. 53. N. C. Sturgess, M. L. Ashford, D. L. Cook and C. N. Hales, The sulphonylurea receptor may be an ATP-sensitive potassium channel, Lancet326 (1985) 474–475; DOI: 10.1016/S0140-6736(85)90403-9.10.1016/S0140-6736(85)90403-9
    Search in Google Scholar
  54. 54. F. M. Gribble, S. J. Tucker and F. M. Ashcroft, The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation, J. Physiol. 504 (1997) 35–45; DOI: 10.1111/j.1469-7793.1997.00035.x.10.1111/j.1469-7793.1997.00035.x11599339350615
    Search in Google Scholar
  55. 55. F. M. Gribble and F. M. Ashcroft, Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide, Diabetologia42 (1999) 845–848; DOI: 10.1007/s001250051236.10.1007/s00125005123610440127
    Search in Google Scholar
  56. 56. F. Reimann, P. Proks and F. M. Ashcroft, Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel, Br. J. Pharmacol. 132 (2001) 1542–1548; DOI: 10.1038/sj.bjp.0703962.10.1038/sj.bjp.0703962157269711264248
    Search in Google Scholar
  57. 57. Y. Sunaga, T. Gonoi, T. Shibasaki, K. Ichikawa, H. Kusama, H. Yano and S. Seino, The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide, Eur. J. Pharmacol. 431 (2001) 119–125; DOI: 10.1016/S0014-2999(01)01412-1.10.1016/S0014-2999(01)01412-1
    Search in Google Scholar
  58. 58. F. M. Ashcroft and F. M. Gribble, Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels, J. Diabetes Compl. 14 (2000) 192–196; DOI: 10.1016/S1056-8727(00)00081-7.10.1016/S1056-8727(00)00081-7
    Search in Google Scholar
  59. 59. S. Hu, S. Wang and B. E. Dunning, Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and beta-cell K(ATP) channels, J. Pharmacol. Exp. Ther. 291 (1999) 1372–1379.
    Search in Google Scholar
  60. 60. A. Melander, Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes: brief overview, Diabetes53 (2004) S151–S155; DOI: 10.2337/diabetes.53.suppl_3.S151.10.2337/diabetes.53.suppl_3.S151
    Search in Google Scholar
  61. 61. R. I. Shorr, W. A. Ray, J. R. Daugherty and M. R. Griffin, Individual sulfonylureas and serious hypoglycemia in older people, J. Am. Geriatr. Soc. 44 (1996) 751–755; DOI: 10.1111/j.1532-5415.1996.tb03729.x.10.1111/j.1532-5415.1996.tb03729.x
    Search in Google Scholar
  62. 62. A. Jonsson, T. Rydberg, G. Ekberg, B. Hallengren and A. Melander, Slow elimination of glyburide in NIDDM subjects, Diabetes Care17 (1994) 142–145; DOI: 10.2337/diacare.17.2.142.10.2337/diacare.17.2.142
    Search in Google Scholar
  63. 63. A. Holstein, A. Plaschke and E. H. Egberts, Lower incidence of severe hypoglycaemia in patients with type 2 diabetes treated with glimepiride versus glibenclamide, Diabetes Metab. Res. Rev. 17 (2001) 467–473; DOI: 10.1002/dmrr.235.10.1002/dmrr.235
    Search in Google Scholar
  64. 64. A. Basit, M. Riaz and A. Fawwad, Glimepiride: evidence-based facts, trends, and observations, Vasc. Health Risk Manag. 8 (2012) 463–472; DOI: 10.2147/HIV.S33194.
    Search in Google Scholar
  65. 65. J. A. Hirst, A. J. Farmer, A. Dyar, T. W. Lung and R. J. Stevens, Estimating the effect of sulfonylurea on HbA1c in diabetes: a systematic review and meta-analysis, Diabetologia56 (2013) 973–984; DOI: 10.1007/s00125-013-2856-6.10.1007/s00125-013-2856-6
    Search in Google Scholar
  66. 66. K. Kaku, Y. Inoue and T. Kaneko, Extrapancreatic effects of sulfonylurea drugs, Diabetes Res. Clin. Pract. 28 (1995) S105–S108; DOI: 10.1016/0168-8227(95)01078-R.10.1016/0168-8227(95)01078-R
    Search in Google Scholar
  67. 67. A. Terzic, A. Jahangir and Y. Kurachi, Cardiac ATP-sensitive K+ channels: regulation by intracellular nucleotides and K+ channel-opening drugs, Am. J. Physiol. 269 (1995) C525–C545.10.1152/ajpcell.1995.269.3.C5257573382
    Search in Google Scholar
  68. 68. J. P. Arena and R. S. Kass, Activation of ATP-sensitive K channels in heart cells by pinacidil: dependence on ATP, Am. J. Physiol. 257 (1989) H2092–2096.
    Search in Google Scholar
  69. 69. G. Edwards, T. Ibbotson and A. H. Weston, Levcromakalim may induce a voltage-independent K-current in rat portal veins by modifying the gating properties of the delayed rectifier, Br. J. Pharmacol. 110 (1993) 1037–1048; DOI: 10.1111/j.1476-5381.1993.tb13918.x.10.1111/j.1476-5381.1993.tb13918.x21758028298792
    Search in Google Scholar
  70. 70. M. Schwanstecher, C. Sieverding, H. Dorschner, I. Gross, L. Aguilar-Bryan, C. Schwanstecher and J. Bryan, Potassium channel openers require ATP to bind to and act through sulfonylurea receptors, EMBO J. 17 (1998) 5529–5535; DOI: 10.1093/emboj/17.19.5529.10.1093/emboj/17.19.5529
    Search in Google Scholar
  71. 71. S. Shyng, T. Ferrigni and C. G. Nichols, Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor, J. Gen. Physiol. 110 (1997) 643–654; DOI: 10.1085/jgp.110.6.643.10.1085/jgp.110.6.643
    Search in Google Scholar
  72. 72. F. M. Gribble, F. Reimann, R. Ashfield and F. M. Ashcroft, Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A, Mol. Pharmacol. 57 (2000) 1256–1261.
    Search in Google Scholar
  73. 73. C. Moreau, A. L. Prost, R. Derand and M. Vivaudou, SUR, ABC proteins targeted by KATP channel openers, J. Mol. Cell Cardiol. 38 (2005) 951–963; DOI: 10.1016/j.yjmcc.2004.11.030.10.1016/j.yjmcc.2004.11.030
    Search in Google Scholar
  74. 74. A. P. Babenko, G. Gonzalez and J. Bryan, Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers, J. Biol. Chem. 275 (2000) 717–720; DOI: 10.1074/jbc.275.2.717.10.1074/jbc.275.2.717
    Search in Google Scholar
  75. 75. I. Uhde, A. Toman, I. Gross, C. Schwanstecher and M. Schwanstecher, Identification of the potassium channel opener site on sulfonylurea receptors, J. Biol. Chem. 274 (1999) 28079–28082; DOI: 10.1074/jbc.274.40.28079.10.1074/jbc.274.40.28079
    Search in Google Scholar
  76. 76. G. Edwards and A. H. Weston, Potassium channel openers and vascular smooth muscle relaxation, Pharmacol. Ther. 48 (1990) 237–258; DOI: 10.1016/0163-7258(90)90082-D.10.1016/0163-7258(90)90082-D
    Search in Google Scholar
  77. 77. A. H. Weston, J. Longmore, D. T. Newgreen, G. Edwards, K. M. Bray and S. Duty, The potassium channel openers: a new class of vasorelaxants, Blood Vessels. 27 (1990) 306–313; DOI 10.1159/000158823.
    Search in Google Scholar
  78. 78. J. C. Clapham, In Vivo Vascular Effects of Potassium Channel Activation in Isolated Blood Vessels, in Potassium Channels and Their Modulators (Ed. J. M. Evans), 1st ed., Taylor & Francis, London 1996, pp. 448.
    Search in Google Scholar
  79. 79. M. Burian, M. Piske, D. Petkovic and V. Mitrovic, Lack of anti-ischemic efficacy of the potassium channel opener bimakalim in patients with stable angina pectoris, Cardiovasc. Drugs Ther. 18 (2004) 37–46; DOI: 10.1023/B:CARD.0000025754.08942.03.10.1023/B:CARD.0000025754.08942.03
    Search in Google Scholar
  80. 80. H. Ueda, Y. Nakayama, K. Tsumura, K. Yoshimaru, T. Hayashi and J. Yoshikawa, Intravenous nicorandil can reduce the occurrence of ventricular fibrillation and QT dispersion in patients with successful coronary angioplasty in acute myocardial infarction, Can. J. Cardiol. 20 (2004) 625–629.
    Search in Google Scholar
  81. 81. I. S. Group, Effect of nicorandil on coronary events in patients with stable angina: the impact of nicorandil in angina (IONA) randomised trial, Lancet359 (2002) 1269–1275; DOI: 10.1016/S0140-6736(02)08265-X.10.1016/S0140-6736(02)08265-X
    Search in Google Scholar
  82. 82. D. J. Milligan and A. M. Fields, Levosimendan: calcium sensitizer and inodilator, Anesthesiol. Clin. 28 (2010) 753–760; DOI: 10.1016/j.anclin.2010.08.003.10.1016/j.anclin.2010.08.003
    Search in Google Scholar
  83. 83. F. Follath, J. G. F. Cleland, H. Just, J. G. Y. Papp, H. Scholz, K. Peuhkurinen, V. P. Harjola, V. Mitrovic, M. Abdalla, E.-P. Sandell and L. Lehtonen, for the Steering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study, Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial, Lancet360 (2002) 196–202; DOI: 10.1016/S0140-6736(02)09455-2.10.1016/S0140-6736(02)09455-2
    Search in Google Scholar
  84. 84. V. S. Moiseyev, P. Poder, N. Andrejevs, M. Y. Ruda, A. P. Golikov, L. B. Lazebnik, Z. D. Kobalava, L. A. Lehtonen, T. Laine, M. S. Nieminen, K. I. Lie and RUSSLAN Study Investigators, Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double-blind study (RUSS-LAN), Eur. Heart J. 23 (2002) 1422–1432.10.1053/euhj.2001.315812208222
    Search in Google Scholar
DOI: https://doi.org/10.1515/acph-2016-0006 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
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Language: English
Page range: 23 - 34
Accepted on: Sep 15, 2015
Published on: Mar 7, 2016
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
ATP-sensitive potassium channels,
therapeutic agents,
diabetes,
cardiovascular,
inwardly rectifying potassium channels,
sulphonylurea receptor
Related subjects:
Pharmacy,
Pharmacy, other

© 2016 Hussein N. Rubaiy, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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