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Detection of brain metastases using alternative magnetic resonance imaging sequences: a comparison between SPACE and VIBE sequences Cover

Detection of brain metastases using alternative magnetic resonance imaging sequences: a comparison between SPACE and VIBE sequences

Asian Biomedicine
Volume 14 (2020): Issue 1 (February 2020)
By: Sutasinee Kongpromsuk,  Nantaporn Pitakvej,  Nutchawan Jittapiromsak and  Supada Prakkamakul  
Open Access
|Jul 2020

Figures & Tables

Figure 1

A 58-year-old lung cancer patient with a brain metastasis in the right occipital lobe (white arrow) that was missed by readers on contrast-enhanced 3D T1-weighted VIBE on a separate reading. Axial contrast-enhanced 3D T1-weighted SPACE (A) shows higher contrast enhancement compared with axial contrast-enhanced 3D T1-weighted VIBE (B).

Figure 2

A 76-year-old lung cancer patient with a brain metastasis in the right temporal lobe (white arrow) that was missed by readers on contrast-enhanced 3D T1-weighted SPACE. Axial contrast-enhanced 3D T1-weighted SPACE (A) and contrast-enhanced 3D T1-weighted VIBE (B). The degree of enhancement is similar on both sequences. However, this lesion was missed because it located close to a vessel and was mistaken for an incompletely suppressed vascular signal on contrast-enhanced 3D T1-weighted SPACE (A). Axial contrast-enhanced 3D T1-weighted VIBE (B) clearly distinguishes parenchymal enhancing lesion and adjacent vascular structure.

Figure 3

A scatter plot demonstrates correlation between the number of enhancing lesions on 3D T1-weighted SPACE and 3D T1-weighted VIBE. The black line represents the line of identity when y = x. The dotted line represents a trend line which was linearly fitted from the raw data. Note that the trend line lies above the line of identity which reflects a systematic difference between the two sequences.

Figure 4

The Bland–Altman plot demonstrates higher variability when the number of the enhancing lesions is large. The dotted line shows value of zero.

Figure 5

A 60-year-old lung cancer patient with a tiny enhancing lesion in the left cerebellar hemisphere (white arrow) that was not visible on contrast-enhanced 3D T1-weighted SPACE in head-to-head analysis. Axial contrast-enhanced 3D T1-weighted VIBE (B) shows a tiny enhancing lesion while contrast-enhanced 3D T1-weighted SPACE (A) shows no visible lesion.

Figure 6

A 53-year-old breast cancer patient with a tiny metastasis in the right frontal lobe (white arrow) that was not visible on contrast-enhanced 3D T1-weighted VIBE in head-to-head analysis. Axial contrast-enhanced 3D T1-weighted SPACE (A) shows a tiny enhancing lesion while contrast-enhanced 3D T1-weighted VIBE (B) shows no visible lesion.

Figure 7

A 62-year-old lung cancer patient with a false-positive lesion in the left temporal lobe (white arrow). Axial contrast-enhanced 3D T1-weighted SPACE (A) and contrast-enhanced 3D T1-weighted VIBE (B). A false-positive lesion is a partial hyperintensity of a blood vessel which mimics enhancing brain metastasis on contrast-enhanced 3D T1-weighted SPACE (A). The linear hyperintensity continues as a vascular structure on contrast-enhanced 3D T1-weighted VIBE (B).

Results of detection of parenchymal enhancing lesions on 3D T1-weighted SPACE and 3D T1-weighted VIBE

ParametersImaging sequence
3D T1-weighted SPACE3D T1-weighted VIBEP
Separate reading
  Total number of enhancing lesions424378
  Median number of enhancing lesions650.008*
  Range1–1221–117
Interquartile range1814
Head-to-head comparison
  Number of truly missed lesions17
  Number of false-positive lesions33
Interobserver reliability
  Intraclass correlation coefficient0.9990.998

Magnetic resonance imaging parameters

Parameters3D T1-weighted SPACE3D T1-weighted VIBE
TR (ms)50020
TE (ms)203.69
Flip angles (degree)Variable12
Reconstructed slice thickness (mm)0.981
Voxel size (mm)0.98 × 0.98 × 0.980.65 × 0.62 × 1.25
Echo-train length35Not applicable
Matrix size256 × 256 × 176320 × 272 (85% of read) × 128 mm (80% of slice per slab)
Field of view250 × 250210 × 171
Partition directionN/AZero-filled with 160 points
Bandwidth (hertz per pixel)621130
Number of acquisition (NEX)11
Acquisition planeSagittalAxial
Acceleration factor22
Fat suppressionNoYes
Acquisition time (min:s)4:474:51
DOI: https://doi.org/10.1515/abm-2020-0005 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
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Language: English
Page range: 27 - 35
Published on: Jul 13, 2020
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year
Keywords:
brain,
diagnostic tests,
magnetic resonance imaging,
neoplasm metastasis
Related subjects:
Medicine,
Assistive professions, nursing,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other

© 2020 Sutasinee Kongpromsuk, Nantaporn Pitakvej, Nutchawan Jittapiromsak, Supada Prakkamakul, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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