Potassium channel inhibitors induce oxidative stress in breast cancer cells

Öner, Çağri; Çolak, Ertuğrul; Coşan, Didem Turgut

doi:10.1515/abm-2018-0004

References

Sosa V, Moline T, Somoza R, Paciucci R, Kondoh H, ME LL. Oxidative stress and cancer: an overview. Ageing Res Rev. 2013; 12:376–90.10.1016/j.arr.2012.10.00423123177
Open DOI Search in Google Scholar Back to article
Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013; 12:931–47.2428778110.1038/nrd4002
Open DOI Search in Google Scholar Back to article
Gupta R, Sikka SC. Prostate cancer and oxidative stress. In: Laher I, editor. Systems biology of free radicals and antioxidants. Berlin: Springer-Verlag; 2014. p. 2835–50.
Search in Google Scholar Back to article
Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C. Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer. 2007; 121:2381–6.1789386810.1002/ijc.23192
Open DOI Search in Google Scholar Back to article
Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer. 2011; 11:85–95.10.1038/nrc298121258394
Open DOI Search in Google Scholar Back to article
Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 2009; 458:780–3.10.1038/nature0773319194462
Open DOI Search in Google Scholar Back to article
Hecht F, Pessoa CF, Gentile LB, Rosenthal D, Carvalho DP, Fortunato RS. The role of oxidative stress on breast cancer development and therapy. Tumour Biol. 2016; 37:4281–91.10.1007/s13277-016-4873-9
Open DOI Search in Google Scholar Back to article
Hernandes MS, Troncone LRP. Glycine as a neurotransmitter in the forebrain: a short review. J Neural Transm (Vienna). 2009; 116:1551–60.10.1007/s00702-009-0326-6
Open DOI Search in Google Scholar Back to article
Leanza L, Zoratti M, Gulbins E, Szabo I. Mitochondrial ion channels as oncological targets. Oncogene. 2014; 33:5569–81.10.1038/onc.2013.57824469031
Open DOI Search in Google Scholar Back to article
Villalonga N, Ferreres JC, Argilés JM, Condom E, Felipe A. Potassium channels are a new target field in anticancer drug design. Recent Pat Anticancer Drug Discov. 2007; 2:212–23.1822106410.2174/157489207782497181
Open DOI Search in Google Scholar Back to article
Leanza L, Managò A, Zoratti M, Gulbins E, Szabo I. Pharmacological targeting of ion channels for cancer therapy: In vivo evidences. Biochim Biophys Acta. 2016; 1863:1385–97.2665864210.1016/j.bbamcr.2015.11.032
Open DOI Search in Google Scholar Back to article
Urrego D, Tomczak AP, Zahed F, Stühmer W, Pardo LA. Potassium channels in cell cycle and cell proliferation. Philos Trans R Soc Lond B Biol Sci. 2014; 369:20130094, 10.1098/rstb.2013.0094.24493742
Open DOI Search in Google Scholar Back to article
Jang SH, Choi SY, Ryu PD, Lee SY. Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo. Eur J Pharmacol. 2011; 651:26–32.2108760210.1016/j.ejphar.2010.10.066
Open DOI Search in Google Scholar Back to article
Borowiec AS, Hague F, Harir N, Guénin S, Guerineau F, Gouilleux F, et al. IGF-1 activates hEAG K⁺ channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation. J Cell Physiol. 2007; 212:690–701.10.1002/jcp.2106517520698
Open DOI Search in Google Scholar Back to article
Brevet M, Ahidouch A, Sevestre H, Merviel P, El Hiani Y, Robbe M, et al. Expression of K⁺ channels in normal and cancerous human breast. Histol Histopathol. 2008; 23:965–72.18498071
Search in Google Scholar Back to article
So EC, Huang Y-M, Hsing C-H, Liao Y-K, Wu S-N. Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines. Eur J Pharmacol. 2015; 758:177–87.2584341410.1016/j.ejphar.2015.03.065
Open DOI Search in Google Scholar Back to article
Leanza L, Venturini E, Kadow S, Carpinteiro A, Gulbins E, Becker KA. Targeting a mitochondrial potassium channel to fight cancer. Cell Calcium. 2015; 58:131–8.10.1016/j.ceca.2014.09.00625443654
Open DOI Search in Google Scholar Back to article
Hu L, Pennington M, Jiang Q, Whartenby KA, Calabresi PA. Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4⁺ T lymphocytes. J Immunol. 2007; 179:4563–70.10.4049/jimmunol.179.7.456317878353
Open DOI Search in Google Scholar Back to article
García-Quiroz J, Camacho J. Astemizole: an old anti-histamine as a new promising anti-cancer drug. Anticancer Agents Med Chem. 2011; 11:307–14.2144350410.2174/187152011795347513
Open DOI Search in Google Scholar Back to article
Kim Y, Kim WJ, Cha EJ. Quercetin-induced growth inhibition in human bladder cancer cells is associated with an increase in Ca²⁺-activated K⁺ channels. Korean J Physiol Pharmacol. 2011; 15:279–83.10.4196/kjpp.2011.15.5.279
Open DOI Search in Google Scholar Back to article
Jang SH, Kang KS, Ryu PD, Lee SY. Kv1.3 voltage-gated K⁺ channel subunit as a potential diagnostic marker and therapeutic target for breast cancer. BMB Rep. 2009; 42:535–9.1971259210.5483/BMBRep.2009.42.8.535
Open DOI Search in Google Scholar Back to article
Chin LS, Park CC, Zitnay KM, Sinha M, DiPatri AJ Jr., Perillán P, et al. 4-Aminopyridine causes apoptosis and blocks an outward rectifier K⁺ channel in malignant astrocytoma cell lines. J Neurosci Res. 1997; 48:122–7.10.1002/(SICI)1097-4547(19970415)48:2<;122::AID-JNR4>3.0.CO;2-E9130140
Open DOI Search in Google Scholar Back to article
Ru Q, Tian X, Wu YX, Wu RH, Pi MS, Li CY. Voltage-gated and ATP-sensitive K⁺ channels are associated with cell proliferation and tumorigenesis of human glioma. Oncol Rep. 2014; 31:842–8.10.3892/or.2013.287524284968
Open DOI Search in Google Scholar Back to article
Liu J, Feng S, Zhang L, Wu Z, Chen Q, Cheng W, et al. [Expression and properties of potassium channels in human mammary epithelial cell line MCF10A and its possible role in proliferation]. Sheng Li Xue Bao [Acta Physiologica Sinica]. 2010; 62:203–9. [in Chinese, English abstract].20571736
Search in Google Scholar Back to article
Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, et al. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med. 2012; 4:577–93.2249611710.1002/emmm.201200235
Open DOI Search in Google Scholar Back to article
de Guadalupe Chávez-Lòpez M, Hernández-Gallegos E, Vázquez-Sánchez AY, Gariglio P, Camacho J. Antiproliferative and proapoptotic effects of astemizole on cervical cancer cells. Int J Gynecol Cancer. 2014; 24:824–8.10.1097/IGC.000000000000015124819656
Open DOI Search in Google Scholar Back to article
Ouadid-Ahidouch H, Le Bourhis X, Roudbaraki M, Toillon RA, Delcourt P, Prevarskaya N. Changes in the K⁺ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h.ether-á-gogo K⁺ channel. Receptors Channels. 2001; 7:345–56.
Search in Google Scholar Back to article
Breier A, Gibalova L, Seres M, Barancik M, Sulova Z. New insight into p-glycoprotein as a drug target. Anticancer Agents Med Chem. 2013; 13:159–70.2293141310.2174/187152013804487380
Open DOI Search in Google Scholar Back to article
Jahchan NS, Dudley JT, Mazur PK, Flores N, Yang D, Palmerton A, et al. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 2013; 3:1364–77.10.1158/2159-8290.CD-13-018324078773
Open DOI Search in Google Scholar Back to article
García-Quiroz J, García-Becerra R, Santos-Martínez N, Barrera D, Ordaz-Rosado D, Avila E, et al. In vivo dual targeting of the oncogenic Ether-á-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors. BMC Cancer. 2014; 14:745, 10.1186/1471-2407-14-745.25280486
Open DOI Search in Google Scholar Back to article
Venturini E. Kv1.3 inhibitors in the treatment of glioma and melanoma [doctoral dissertation]. Germany: Universität Duisburg-Essen; 2015.
Search in Google Scholar Back to article
Stone JR, Yang S. Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal. 2006; 8:243–70.10.1089/ars.2006.8.24316677071
Open DOI Search in Google Scholar Back to article
Dyugovskaya L, Lavie P, Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med. 2002; 165:934–9.1193471710.1164/ajrccm.165.7.2104126
Open DOI Search in Google Scholar Back to article
Chattopadhyay MK, Tabor CW, Tabor H. Polyamine deficiency leads to accumulation of reactive oxygen species in a spe2Δ mutant of Saccharomyces cerevisiae. Yeast. 2006; 23:751–61.10.1002/yea.1393
Open DOI Search in Google Scholar Back to article
Hermann A, Sitdikova GF, Weiger TM. Oxidative stress and maxi calcium-activated potassium (BK) channels. Biomolecules. 2015; 5:1870–911.10.3390/biom503187026287261
Open DOI Search in Google Scholar Back to article
Agostinelli E, Tempera G, Viceconte N, Saccoccio S, Battaglia V, Grancara S, et al. Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach. Amino Acids. 2010; 38:353–68.10.1007/s00726-009-0431-820012114
Open DOI Search in Google Scholar Back to article
Szabó I, Bock J, Grassmé H, Soddemann M, Wilker B, Lang F, et al. Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci U S A. 2008; 105:14861–6.1881830410.1073/pnas.0804236105
Open DOI Search in Google Scholar Back to article
Jakhar R, Paul S, Bhardwaj M, Kang SC. Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis. Cancer Lett. 2016; 372:89–100.2673906110.1016/j.canlet.2015.12.024
Open DOI Search in Google Scholar Back to article
Woodfork KA, Wonderlin WF, Peterson VA, Strobl JS. Inhibition of ATP-sensitive potassium channels causes reversible cell-cycle arrest of human breast cancer cells in tissue culture. J Cell Physiol. 1995; 162:163–71.782242710.1002/jcp.1041620202
Open DOI Search in Google Scholar Back to article
Ouadid-Ahidouch H, Roudbaraki M, Delcourt P, Ahidouch A, Joury N, Prevarskaya N. Functional and molecular identification of intermediate-conductance Ca²⁺-activated K⁺ channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol. 2004; 287:C125–34.1498523710.1152/ajpcell.00488.2003
Open DOI Search in Google Scholar Back to article
Zhang P, Yang X, Yin Q, Yi J, Shen W, Zhao L, et al. Inhibition of SK4 potassium channels suppresses cell proliferation, migration and the epithelial–mesenchymal transition in triple-negative breast cancer cells. PLoS One. 2016; 11:e0154471, 10.1371/journal.pone.0154471.27124117
Open DOI Search in Google Scholar Back to article

Potassium channel inhibitors induce oxidative stress in breast cancer cells

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