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Potassium channel inhibitors induce oxidative stress in breast cancer cells Cover

Potassium channel inhibitors induce oxidative stress in breast cancer cells

Asian Biomedicine
Volume 11 (2017): Issue 4 (August 2017)
By: Çağri Öner,  Ertuğrul Çolak and  Didem Turgut Coşan  
Open Access
|Mar 2018

Figures & Tables

Figure 1

The effects of voltage-gated potassium channel inhibitors on the total antioxidant, oxidant, and oxidative stress levels of MCF-7 breast cancer cells. (A) The effects of tetraethyl ammonium chloride (TEA), 4-aminopyridine (4-AP), margatoxin (MgTX), or astemizole (AST) on the total antioxidant levels in MCF-7 cells. (B) The effects of TEA, 4-AP, MgTX, or AST on the total oxidant level in MCF-7 cells. (C) The effects of TEA, 4-AP, MgTX, or AST on the oxidative stress level in MCF-7 cells. n = 7 for each experiment group; error bars = 10 standard deviations. ∗P < 0.001
The effects of voltage-gated potassium channel inhibitors on the total antioxidant, oxidant, and oxidative stress levels of MCF-7 breast cancer cells. (A) The effects of tetraethyl ammonium chloride (TEA), 4-aminopyridine (4-AP), margatoxin (MgTX), or astemizole (AST) on the total antioxidant levels in MCF-7 cells. (B) The effects of TEA, 4-AP, MgTX, or AST on the total oxidant level in MCF-7 cells. (C) The effects of TEA, 4-AP, MgTX, or AST on the oxidative stress level in MCF-7 cells. n = 7 for each experiment group; error bars = 10 standard deviations. ∗P < 0.001

Figure 2

The effects of voltage-gated potassium channel inhibitors on the total antioxidant, oxidant and oxidative stress levels of MDA-MB-231 breast cancer cells. (A) The effects of tetraethyl ammonium chloride (TEA), 4-aminopyridine (4-AP), margatoxin (MgTX), and astemizole (AST) on the total antioxidant levels in MDA-MB-231 cells. (B) The effects of TEA, 4-AP, MgTX, and AST on the total oxidant level in MDA-MB-231 cells. (C) The effects of TEA, 4-AP, MgTX, and AST on the oxidative stress level of MDA-MB-231 cells. n = 7 for each experiment group; error bars = 10 standard deviations; ∗P < 0.001
The effects of voltage-gated potassium channel inhibitors on the total antioxidant, oxidant and oxidative stress levels of MDA-MB-231 breast cancer cells. (A) The effects of tetraethyl ammonium chloride (TEA), 4-aminopyridine (4-AP), margatoxin (MgTX), and astemizole (AST) on the total antioxidant levels in MDA-MB-231 cells. (B) The effects of TEA, 4-AP, MgTX, and AST on the total oxidant level in MDA-MB-231 cells. (C) The effects of TEA, 4-AP, MgTX, and AST on the oxidative stress level of MDA-MB-231 cells. n = 7 for each experiment group; error bars = 10 standard deviations; ∗P < 0.001
DOI: https://doi.org/10.1515/abm-2018-0004 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
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Language: English
Page range: 323 - 330
Published on: Mar 21, 2018
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year
Keywords:
4-aminopyridine,
astemizole,
breast cancer,
margatoxin,
oxidative stress,
tetraethylammonium chloride
Related subjects:
Medicine,
Assistive professions, nursing,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other

© 2018 Çağri Öner, Ertuğrul Çolak, Didem Turgut Coşan, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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