Heart Failure in Adult Congenital Heart Disease

Jessica N. Richardson; Cindy M. Martin

doi:10.14797/mdcvj.1815

Heart Failure in Adult Congenital Heart Disease

Methodist DeBakey Cardiovascular Journal

Volume 22 (2026): Issue 3

By: Jessica N. Richardson and Cindy M. Martin

Open Access

|Jun 2026

Agasthi P, Van Houten HK, Yao X, et al. Mortality and Morbidity of Heart Failure Hospitalization in Adult Patients With Congenital Heart Disease. J Am Heart Assoc. 2023 Dec 5;12(23):e030649. doi: 10.1161/JAHA.123.030649
Open DOI Search in Google Scholar Back to article
Bozkurt B, Coats AJ, Tsutsui H, et al. Universal Definition and Classification of Heart Failure: A Report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure. J Card Fail. 2021 Apr;27(4):387-413. doi: 10.1016/j.cardfail.2021.01.022
Open DOI Search in Google Scholar Back to article
Chaudhry A, Selwyn J, Adams E, Bradley EA. Heart Failure in Complex Congenital Heart Disease of the Adult. Curr Cardiol Rep. 2022 Nov;24(11):1727-1735. doi: 10.1007/s11886-022-01788-0
Open DOI Search in Google Scholar Back to article
Maegaard Eriksen V, Lim CW, Thuraiaiyah J, et al. Heart failure with preserved ejection fraction in adults with congenital heart disease. Eur Heart J. 2026 Jan 30:ehag017. doi: 10.1093/eurheartj/ehag017
Open DOI Search in Google Scholar Back to article
Smit-Fun VM, Buhre WF. Heart Failure in Adult Patients with Congenital Heart Disease. Anesthesiol Clin. 2019 Dec;37(4):751-768. doi: 10.1016/j.anclin.2019.08.005
Open DOI Search in Google Scholar Back to article
Szugye N. Greater than the sum of its parts: multimodality imaging in adults with congenital heart disease. Cardiovasc Diagn Ther. 2024 Dec 31;14(6):1176-1185. doi: 10.21037/cdt-24-363
Open DOI Search in Google Scholar Back to article
Kempny A, Dimopoulos K, Uebing A, et al. Reference values for exercise limitations among adults with congenital heart disease. Relation to activities of daily life--single centre experience and review of published data. Eur Heart J. 2012 Jun;33(11):1386-1396. doi: 10.1093/eurheartj/ehr461
Open DOI Search in Google Scholar Back to article
Diller GP, Dimopoulos K, Okonko D, et al. Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication. Circulation. 2005 Aug 9;112(6):828-835. doi: 10.1161/CIRCULATIONAHA.104.529800
Open DOI Search in Google Scholar Back to article
Gurvitz M, Krieger EV, Fuller S, et al.; Writing Committee Members. 2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026 Feb 24;153(8):e115-e251. doi: 10.1161/CIR.0000000000001402
Open DOI Search in Google Scholar Back to article
Jone P-N, Ivy DD, Hauck A, et al. Pulmonary Hypertension in Congenital Heart Disease: A Scientific Statement From the American Heart Association. Circ Heart Fail. 2023 Jul;16(7):e00080. doi: 10.1161/HHF.0000000000000080
Open DOI Search in Google Scholar Back to article
Duarte VE, Rajpal S. The Role of Multimodality Imaging in the Evaluation of Heart Failure and Surgical Transplant Planning of Patients with Adult Congenital Heart Disease. Heart Fail Clin. 2024 Apr;20(2):189-198. doi: 10.1016/j.hfc.2024.01.002
Open DOI Search in Google Scholar Back to article
Alonso-Gonzalez R, Lopez-Guarch CJ, Subirana-Domenech MT, et al. Pulmonary hypertension and congenital heart disease: An insight from the REHAP National Registry. Int J Cardiol. 2015 Apr 1:184:717-723. doi: 10.1016/j.ijcard.2015.02.031
Open DOI Search in Google Scholar Back to article
Ghonim S, Voges I, Gatehouse PD, et al. Myocardial Architecture, Mechanics, and Fibrosis in Congenital Heart Disease. Front Cardiovasc Med. 2017 May 23:4:30. doi: 10.3389/fcvm.2017.00030
Open DOI Search in Google Scholar Back to article
Gordon B, González-Fernández V, Dos-Subirà L. Myocardial fibrosis in congenital heart disease. Front Pediatr. 2022 Nov 18:10:965204. doi: 10.3389/fped.2022.965204
Open DOI Search in Google Scholar Back to article
Carazo M. Medical Therapy for Heart Failure in Adult Congenital Heart Disease Patients. Struct Heart. 2024 Apr 10;8(4):100297. doi: 10.1016/j.shj.2024.100297
Open DOI Search in Google Scholar Back to article
Moore JP, Marelli A, Burchill LJ, et al. Management of Heart Failure With Arrhythmia in Adults With Congenital Heart Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022 Dec 6;80(23):2224-2238. doi: 10.1016/j.jacc.2022.09.038
Open DOI Search in Google Scholar Back to article
Greene SJ, Butler J, Albert NM, et al. Medical Therapy for Heart Failure With Reduced Ejection Fraction: The CHAMP-HF Registry. J Am Coll Cardiol. 2018 Jul 24;72(4):351-366. doi: 10.1016/j.jacc.2018.04.070
Open DOI Search in Google Scholar Back to article
Alipour Symakani RS, Van Genuchten WJ, Zandbergen LM, et al. The right ventricle in tetralogy of Fallot: adaptation to sequential loading. Front Pediatr. 2023 Mar 16:11:1098248. doi: 10.3389/fped.2023.1098248
Open DOI Search in Google Scholar Back to article
Panaioli E, Birritella L, Graziani F, et al. RV–PA coupling in repaired ToF with pulmonary regurgitation: Clinical implications. Arch Cardiovasc Dis. 2022 Feb;115(2):67-77. doi: 10.1016/j.acvd.2021.12.006
Open DOI Search in Google Scholar Back to article
Spalart V, Cieplucha A, Budts W, et al. Subpulmonary ventricular function and inflammation are related to clinical heart failure in patients with a systemic right ventricle. Int J Cardiol Congenit Heart Dis. 2024 Jul 31:17:100535. doi: 10.1016/j.ijcchd.2024.100535
Open DOI Search in Google Scholar Back to article
Lewis M, Rosenbaum M. When Should Adult Congenital Heart Disease Patients be Considered for Transplant and Deciding Which Organs to Transplant. Prog Cardiovasc Dis. 2018 Sep-Oct;61(3-4):377-381. doi: 10.1016/j.pcad.2018.09.004
Open DOI Search in Google Scholar Back to article
Yasuhara J, Watanabe K, Watanabe A, et al. Pulmonary vasodilator therapies in pulmonary arterial hypertension associated with CHD: a systematic review and network meta-analysis. Cardiol Young. 2023 Nov;33(11):2297-2311. doi: 10.1017/S1047951123000124
Open DOI Search in Google Scholar Back to article
Filippov AA, Del Nido PJ, Vasilyev NV. Management of Systemic Right Ventricular Failure in Patients With Congenitally Corrected Transposition of the Great Arteries. Circulation. 2016 Oct 25;134(17):1293-1302. doi: 10.1161/CIRCULATIONAHA.116.022106
Open DOI Search in Google Scholar Back to article
Fusco F, Di Salvo G, Nyktari E, et al. Recent advances in congenital heart disease with a systemic right ventricle: new insights for heart failure treatment from last EURO-ACHD Congress 2025. Eur Heart J Suppl. 2026 Jan 30;28(Suppl 1):i42-i49. doi: 10.1093/eurheartjsupp/suaf092
Open DOI Search in Google Scholar Back to article
Piran S, Veldtman G, Siu S, Webb GD, Liu PP. Heart failure and ventricular dysfunction in patients with single or systemic right ventricles. Circulation. 2002 Mar 12;105(10):1189-94. doi: 10.1161/hc1002.105182
Open DOI Search in Google Scholar Back to article
McEachern WA, Slesnick TC. Towards Understanding Deterioration in Systemic Right Ventricular Function in the Setting of Tricuspid Regurgitation: Is There a Point of No Return? CJC Pediatr Congenit Heart Dis. 2024 Aug 29;3(5):200-202. doi: 10.1016/j.cjcpc.2024.08.003
Open DOI Search in Google Scholar Back to article
Piana S, Pozza A, Cavaliere A, et al. The Sub-Pulmonary Left Ventricle in Patients with Systemic Right Ventricle, the Paradoxical Neglected Chamber: A Cardiac Magnetic Resonance Feature Tracking Study. J Clin Med. 2024 Oct 10;13(20):6033. doi: 10.3390/jcm13206033
Open DOI Search in Google Scholar Back to article
Deng LX, Gleason LP, Khan AM, et al. Advance Care Planning in Adults with Congenital Heart Disease: A Patient Priority. Int J Cardiol. 2017 Mar 15:231:105-109. doi: 10.1016/j.ijcard.2016.12.185
Open DOI Search in Google Scholar Back to article
Wang F, Liu A, Brophy JM, et al. Determinants of Survival in Older Adults With Congenital Heart Disease Newly Hospitalized for Heart Failure. Circ Heart Fail. 2020 Aug;13(8):e006490. doi: 10.1161/CIRCHEARTFAILURE.119.006490
Open DOI Search in Google Scholar Back to article
Saef J, Montgomery R, Cedars A, et al. Durable Mechanical Circulatory Support in Adult Congenital Heart Disease: Reviewing Clinical Considerations and Experience. J Clin Med. 2022 Jun 3;11(11):3200. doi: 10.3390/jcm11113200
Open DOI Search in Google Scholar Back to article
Garcia AM, Beatty J-T, Nakano SJ. Heart failure in single right ventricle congenital heart disease: physiological and molecular considerations. Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H947-H965. doi: 10.1152/ajpheart.00518.2019
Open DOI Search in Google Scholar Back to article
Oster ME, Knight JH, Suthar D, Amin O, Kochilas LK. Long-Term Outcomes in Single-Ventricle Congenital Heart Disease. Circulation. 2018 Dec 4;138(23):2718-2720. doi: 10.1161/CIRCULATIONAHA.118.036821
Open DOI Search in Google Scholar Back to article
Givertz MM, Defilippis EM, Landzberg MJ, Pinney SP, Woods RK, Valente AM. Advanced Heart Failure Therapies for Adults With Congenital Heart Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 Nov 5;74(18):2295-2312. doi: 10.1016/j.jacc.2019.09.004
Open DOI Search in Google Scholar Back to article
Ortega-Legaspi JM, Saidi A, Rodriguez FH, et al. Heart Failure Management in Adult Congenital Heart Disease: Part II: Nonpharmacological Therapies. J Card Fail Intersect. 2025 Nov 7:1-10. doi: 10.1016/j.yjcafi.2025.10.009
Open DOI Search in Google Scholar Back to article
Bryant R 3rd, Morales D. Overview of adult congenital heart transplants. Ann Cardiothorac Surg. 2018 Jan;7(1):143-151. doi: 10.21037/acs.2018.01.01
Open DOI Search in Google Scholar Back to article
Heng EE, Krishnan A, Elde S, et al. Multiorgan Transplantation for Adult Congenital Heart Disease. J Heart Lung Transplant. 2025 Apr;44(4):S137. doi: 10.1016/j.healun.2025.02.276
Open DOI Search in Google Scholar Back to article
Monaco J, Khanna A, Khazanie P. Transplant and mechanical circulatory support in patients with adult congenital heart disease. Heart Fail Rev. 2020 Jul;25(4):671-683. doi: 10.1007/s10741-020-09976-2
Open DOI Search in Google Scholar Back to article
Shinkawa T, Ichihara Y, Saito S, Ishido M, Inai K, Niinami H. Ventricular assist device for end-stage adult congenital heart disease patients: Current status. J Cardiol. 2023 Apr;81(4):378-384. doi: 10.1016/j.jjcc.2022.09.007
Open DOI Search in Google Scholar Back to article
Landzberg MJ. Palliative Care in Adult Congenital Heart Disease-Associated Advanced Heart Disease. Heart Fail Clin. 2024 Apr;20(2):237-243. doi: 10.1016/j.hfc.2023.12.005
Open DOI Search in Google Scholar Back to article

Authors

Metrics

Articles in this issue

DOI: https://doi.org/10.14797/mdcvj.1815 | Journal eISSN: 1947-6108

Journal RSS Feed

Language: English

Page range: 124 - 135

Submitted on: Mar 2, 2026

Accepted on: Apr 17, 2026

Published on: Jun 30, 2026

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

adult congenital heart disease,

heart failure,

systemic ventricle,

ventricular dysfunction,

heart transplantation,

mechanical circulatory support,

echocardiography,

cardiovascular magnetic resonance

© 2026 Jessica N. Richardson, Cindy M. Martin, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 22 (2026): Issue 3