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Intravascular Ultrasound Imaging-Guided Percutaneous Coronary Intervention: Evidence and Practical Implications Cover

Intravascular Ultrasound Imaging-Guided Percutaneous Coronary Intervention: Evidence and Practical Implications

Open Access
|Oct 2025

Figures & Tables

Table 1

Characteristics of intravascular ultrasound catheters.

CHARACTERISTICSBOSTON SCIENTIFIC OPTICROSSPHILLIPS VOLCANO EAGLE EYEPHILLIPS VOLCANO REVOLUTIONPHILLIPS VOLCANO REFINITYACIST KODAMATERUMO VIEWIT
Transducer frequency40 MHz (50 MHz HD also available)20 MHz45 MHz45 MHz60 MHz40 MHz
Distal shaft profile3.1F3.3F3.2F3F3.2F2.6F
Proximal shaft profile3.1F2.9F3.5F3F3.6F3.2F
Transducer to tip length20 mm10 mm (2.5 mm for short-tip version)30 mm20.5 mm20 mm29 mm
Guiding catheter≥ 5F≥ 5F≥ 6F≥ 5F≥ 6F≥ 5F
Table 2

Characteristics of recent meta-analyses of randomized controlled trials. IVUS: intravascular ultrasound; OCT: optical coherence tomography; MI: myocardial infarction; TLR: target-lesion revascularization

AUTHOR/ YEARNO. OF TRIALS AND PATIENTSOUTCOMES
Khan at al./ 2023420 trials and 11,698 patients comparing intravascular imaging guided PCI vs angiography guided PCICardiac death, MI, stent thrombosis, target vessel revascularization, and TLR
Kuno et al./ 20234432 trials and 22,684 patients comparing intravascular imaging guided, functionally guided vs angiography guided PCITrial defined MACE (composite of cardiovascular death, MI, and TLR)
Giacoppo et al./ 20241324 trials (15,489 patients: IVUS vs angiography, 46.4%; OCT vs angiography: 32.1%; IVUS vs OCT: 21.4%)The two co-primary outcomes were TLR and MI
Stone et al./20243122 trials and 15,694 patients comparing IVUS vs OCT vs angiography-guided PCITLR, defined as the composite of cardiac death, target vessel MI, or TLR
Figure 1

Trends of intravascular ultrasound (IVUS) use in the United States and Japan. To compare the IVUS use rates in percutaneous coronary intervention between the USA and Japan from 2013 to 2019, we extracted data points from provided graphical charts in prior publications.14 For Japan, the data covered up to 2017, which we extrapolated to 2019 using linear extrapolation based on the last observed rate.15 Both datasets were interpolated for smooth transitions between years.

Figure 2

Intravascular ultrasound images of (A) vessel structure and (B) different plaque types.

Figure 3

Stepwise approach of SEE IVUS technique. (1) Angiographic evaluation of lesion in the right coronary artery; (2) identification of stent length using IVUS after evaluating lesion, distal and proximal healthy landing zones; and (3) angiogram after stent placement. IVUS: intravascular ultrasound

Figure 4

Intravascular ultrasound images of coronary stents and complications.

Table 3

Post stenting IVUS criteria used in landmark studies. MSA: minimal stent area; MLA: minimal lumen area

STUDYCRITERIA
MUSIC301. Complete strut apposition
2. Symmetrical stent expansion: minimum/maximum lumen diameter ≥ 0.7
3. Adequate stent expansion
  • If MSA < 9 mm2 then MSA ≥ 90% average reference lumen area or ≥ 100% minimum reference lumen area

  • If MSA > 9 mm2 then MSA > 80% average reference lumen area or ≥ 90% of minimum reference lumen area

IVUS-XPL421. Minimal luminal cross-sectional area greater than the luminal cross-sectional area at the distal reference segment
2. Adequate stent expansion
  • An MLA cross-sectional area greater than the luminal cross-sectional area at the distal reference segment

  • An MLA in the stented segment > 5.0 mm2 or 90% of the MLA at the distal reference segments

ULTIMATE121. An MLA in the stented segment > 5.0 mm2 or 90% of the MLA at the distal reference segments
2. Plaque burden 5 mm proximal or distal to the stent edge < 50%; and
3. No edge dissection involving the media with length more than 3 mm
4. Adequate stent expansion
  • A minimal luminal cross-sectional area greater than the luminal cross-sectional area at the distal reference segment

  • An MLA in the stented segment more than 5.0 mm2 or 90% of the MLA at the distal reference segments

RENOVATE-COMPLEX PCI45Sufficient stent expansion without major stent malapposition to the vessel wall or edge dissection
  • A residual stenosis diameter of < 10% of the reference-vessel diameter for the target lesion as assessed on angiography and an MSA of > 80% of the mean reference lumen area or an absolute MSA of > 5.5 mm2 on IVUS for stenoses in non-left main coronary artery

  • For stenoses in the left main coronary artery, an absolute MSA of > 7 mm2 for the distal left main coronary artery and > 8 mm2 for the proximal left main coronary artery

DOI: https://doi.org/10.14797/mdcvj.1611 | Journal eISSN: 1947-6108
Language: English
Page range: 26 - 36
Submitted on: Apr 7, 2025
Accepted on: May 27, 2025
Published on: Oct 1, 2025
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services

© 2025 Safi U. Khan, Neal S. Kleiman, Alpesh R. Shah, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.