Metabolic Control of Cardiomyocyte Cell Cycle

Ivan Menendez-Montes; Daniel J. Garry; Jianyi (Jay) Zhang; Hesham A. Sadek

doi:10.14797/mdcvj.1309

Metabolic Control of Cardiomyocyte Cell Cycle

Methodist DeBakey Cardiovascular Journal

Volume 19 (2023): Issue 5

By: Ivan Menendez-Montes , Daniel J. Garry , Jianyi (Jay) Zhang and Hesham A. Sadek

Open Access

|Nov 2023

Abstract

Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

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Articles in this issue

DOI: https://doi.org/10.14797/mdcvj.1309 | Journal eISSN: 1947-6108

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Language: English

Page range: 26 - 36

Submitted on: Oct 28, 2023

Accepted on: Oct 31, 2023

Published on: Nov 16, 2023

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

glycolysis,

oxidative phosphorylation,

cardiomyocyte proliferation,

reactive oxygen species,

uridine diphosphate N-acetylglucosamine (UDP GlycNAC),

cardiac regeneration

© 2023 Ivan Menendez-Montes, Daniel J. Garry, Jianyi (Jay) Zhang, Hesham A. Sadek, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 19 (2023): Issue 5