Timing and Targeting of Treatment in Left Ventricular Hypertrophy
By: Deokhwa Nam and Erin L. Reineke
References
- Sen S, Kundu BK, Wu HC, Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart. J Am Heart Assoc. 2013 Jun; 2( 3): e004796.
- Dirkx E, da Costa Martins PA, De Windt LJ. Regulation of fetal gene expression in heart failure. Biochim Biophys Acta. 2013 Dec; 1832( 12): 2414– 24.
- Rajabi M, Kassiotis C, Razeghi P, Taegtmeyer H. Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev. 2007 Dec; 12( 3–4): 331– 43.
- Levine M, Cattoglio C, Tjian R. Looping back to leap forward: transcription enters a new era. Cell. 2014 Mar 27; 157( 1): 13– 25.
- Finck BN Kelly DP. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest. 2006 Mar; 116( 3): 615– 22.
- Madrazo JA Kelly DP. The PPAR trio: regulators of myocardial energy metabolism in health and disease. J Mol Cell Cardiol. 2008 Jun; 44( 6): 968– 75.
- Ahuja P, Zhao P, Angelis E, Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. J Clin Invest. 2010 May; 120( 5): 1494– 505.
- Ong SG, Lee WH, Theodorou L, HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. Cardiovasc Res. 2014 Oct 1; 104( 1): 24– 36.
- Huss JM, Torra IP, Staels B, Giguere V, Kelly DP. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol. 2004 Oct; 24( 20): 9079– 91.
- Finck BN. The PPAR regulatory system in cardiac physiology and disease. Cardiovasc Res. 2007 Jan 15; 73( 2): 269– 77.
- Liang H Ward WF. PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ. 2006 Dec; 30( 4): 145– 51.
- Akazawa H Komuro I. Roles of cardiac transcription factors in cardiac hypertrophy. Circ Res. 2003 May; 92( 10): 1079– 88.
- Liang Q, De Windt LJ, Witt SA, Kimball TR, Markham BE, Molkentin JD. The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. J Biol Chem. 2001 Aug 10; 276( 32): 30245– 53.
- van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011 Jul 26; 108( 30): 12331– 6.
- Reineke EL, Benham A, Soibam B, Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function. J Biol Chem. 2014 Jun 20; 289( 25): 17721– 31.
- Reineke EL, York B, Stashi E, SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. PLoS One. 2012; 7( 12): e53395.
- Nissen SE Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007 Jun 14; 356( 24): 2457– 71.
- Nesto RW, Bell D, Bonow RO, Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care. 2004 Jan; 27( 1): 256– 63.
- Gerdes AM Iervasi G. Thyroid replacement therapy and heart failure. Circulation. 2010 Jul 27; 122( 4): 385– 93.
- Morkin E, Ladenson P, Goldman S, Adamson C. Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects. J Mol Cell Cardiol. 2004 Dec; 37( 6): 1137– 46.
- Miller SC, Huang R, Sakamuru S, Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem Pharmacol. 2010 May 1; 79( 9): 1272– 80.
- Gonda TJ Ramsay RG. Directly targeting transcriptional dysregulation in cancer. Nat Rev Cancer. 2015 Nov; 15( 11): 686– 94.
- Song X, Zhang C, Zhao M, Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10( 10): e0140011.
- Wang L, Yu Y, Chow DC, Characterization of a steroid receptor coactivator small molecule stimulator that over-stimulates cancer cells and leads to cell stress and death. Cancer Cell. 2015 Aug 10; 28( 2): 240– 52.
- McKinsey TA, Zhang CL, Lu J, Olson EN. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000 Nov 2; 408( 6808): 106– 11.
- Epstein JA. Currying favor for the heart. J Clin Invest. 2008 Mar; 118( 3): 850– 2.
- Yoon S Eom GH. HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases. Chonnam Med J. 2016 Jan; 52( 1): 1– 11.
- Wang X, Haswell JR, Roberts CW. Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights. Clin Cancer Res. 2014 Jan 1; 20( 1): 21– 7.
- Dang CV. Links between metabolism and cancer. Genes Dev. 2012 May 1; 26( 9): 877– 890.
- Sayed D, Yang Z, He M, Pfleger JM, Abdellatif M. Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription. Circ Heart Fail. 2015 Jan; 8( 1): 138– 48.
- Doenst T Abel ED. Spotlight on metabolic remodelling in heart failure. Cardiovasc Res. 2011 May 1; 90( 2): 191– 3.
DOI: https://doi.org/10.14797/mdcj-13-1-9 | Journal eISSN: 1947-6108
Language: English
Page range: 9 - 14
Published on: Jan 1, 2017
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services
© 2017 Deokhwa Nam, Erin L. Reineke, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.