A malignant tumor is an actively growing tissue composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches. Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells I the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs their niche and metastasis the regulation of cell surface glycan expression in CSCs tumor endothelial cells and metastasis toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment and in surgical cancer metastasis. This monograph is intended as a primary reference on CSC research for physiologists clinical oncologists stem cell researchers and molecular biologists.
