The book is dedicated to the history and current status of physiologic autoimmunity concept and relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The immune system is a natural componentregulator and direct participant in the physiological activities in a healthy body. The main forms of physiological activity of the immune system are based on the intrinsic abilities of self-identificationself-maintenanceself-regulationand self-reparation - that is recognizing components of the 'self 'i.e. natural autoimmunity. The most ancient and homeostatically important functions of natural autoimmunity are autoclearance as well as construction and support of multicellularity. A considerable number of immune functionsincluding those related to antimicrobial defensederive from these basic ones. Various pathological processes in any organ are usually accompanied by different patterns of cell death andthusby increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonines)which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the aff ected organ. This phenomenon is sanogenic in nature and adaptive in essence. Thereforesecondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. In relation to experimental production and clinical reveal of antibodies towards nuclear antigenspenetrating into living cell nuclei and altering nuclear acid synthesiscell proliferation and functionautoantibodies can be regarded as hormone-like bioregulators of gene expression. Apparentlyimmune system is able to reproduce complementary regulators for various cell receptorsincluding nuclear ones.
Book is uniqueit is a single monograph comprehensively including history and current status of natural autoimmunity problem. It describes a fundamental concept essencial for every branch of Medicine and Pathology. The concept described has broad practical application for Health Carebecause it establishes effective method of early prediction for many different diseasescreates a basis for prophylaxis. Reader has a chance to get rid of old dogmas and acquire new instrument for fruitful theoretical reasoningresearch planning and predictive/preventive practical medical work.
