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Translational Animal Models in Drug Discovery and Development Cover

Translational Animal Models in Drug Discovery and Development

Publisher:Bentham Science
By: Xinkang Wang  
Paid access
|Oct 2012
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Description
Animal models of diseases play a pivotal role in drug discovery and development not only for proof of the concept studies of efficacy PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics physiology anatomy gene expression heterogeneity of disease conditions etc.) not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore partly due to the lack of congruency between animal and human disease models several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs including inflammation neurological diseases cardiovascular and metabolic diseases and oncology.

This e-book is therefore of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.
PDF ISBN: 978-1-60805-469-5
Publisher: Bentham Science
Copyright owner: © 2012 Bentham Science Publishers
Publication date: 2012
Language: English
Pages: 287
Related subjects:
Life sciences,
Molecular biology

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