Fig. 1.
Flowchart of study population
Legend: SAH – Subarachnoid Hemorrhage; TBI– Traumatic Brain Injury.
Table 1.
Demographic and Baseline Patients' Characteristics (n=15)
| Gender, male n (%) | 5 (33) |
| Age, median (P25-P75) | 58 (37–62) |
| LOS in ICU, median (P25-P75) | 23 (15–29) |
| LOS in hospital, median (P25-P75) | 40 (29–64) |
| SAPS II, median (P25-P75) | 47 (28–56) |
| SAPS II mortality %, median (P25-P75) | 39 (9–60) |
| GCS at first aid, median (P25-P75) | 13 (8–15) |
| GCS at hospital, median (P25-P75) | 12 (3–14) |
| SAH H&H, n (%) | |
| I | 0 (0) |
| II | 5 (33) |
| III | 3 (20) |
| IV | 2 (13) |
| V | 5 (33) |
| SAH Fisher, n (%) | |
| 1 | 0 (0) |
| 2 | 0 (0) |
| 3 | 0 (0) |
| 4 | 15 (100) |
| SAH vasospasm, n (%) | 8 (53) |
| Mortality at ICU discharge, n (%) | 2 (13) |
| Creatinine Clearance at admission (ml/min/1.73 m2), median (P25-P75) | |
| MCC | 139 (120–243) |
| CG | 104 (75–155) |
| MDRD | 127 (89–173) |
| CKD-EPI | 112 (83–131) |
| Vasopressors on day 1 (Noradrenaline) Dose (mcg/kg/min), median (P25-P75) | 0.19 (0.07–0.32) |
| Number of patients on diuretics on day 1, n (%) | 2 (15) |
[i] GCS – Glasgow Coma Scale; LOS – length of stay; MCC–Measured Creatinine Clearance; SAH H&H – Hunt and Hess classification for Spontaneous Subarachnoid hemorrhage (SAH); SAH Fisher – Fisher classification for SAH; SAPS II – Simplified Acute Physiology Score; MDRD – abbreviated Modification of Diet in Renal Disease Study Equation; CKD-EPI – Chronic Kidney Disease Epidemiology Collaboration
Fig. 2.
Global Median MCC evolution during the first 14 days of ICU stay
Legend: MCC – Measured Creatinine Clearance (mL/min/1.73 m2); Time – length of stay in ICU (days).
Fig. 3.
Correlation between MCC and PRx
Legend: MCC – Measured Creatinine Clearance (mL/min/1.73 m2); PRx – Pressure reactivity index
Table 2.
Factors associated with creatinine clearance
| Fixed-effect factor | |||
|---|---|---|---|
| Coefficient | CI 95% | p-value | |
| Gender – Female | 15.18 | −43.79;74.07 | 0.615 |
| Age | −1.33 | −2.81;0.15 | 0.080 |
| Number of days (Time) | 0.51 | −1.61;2.64 | 0.635 |
| CPP | 0.64 | −0.30;1.59 | 0.185 |
| PRx | −18.39 | −61.48;23.64 | 0.393 |
| CPP-optCPPPRx | −0.71 | −1.74;0.30 | 0.169 |
| Noradrenaline | −37.15 | −90.77;16.95 | 0.175 |
| Fluid balance | −0.002 | −0.009;0.000 | 0.632 |