Prediction of acute kidney injury in mechanically ventilated patients with COVID-19-related septic shock: An exploratory analysis of non-renal organ dysfunction markers
References
- Molitoris BA. Low-Flow Acute Kidney Injury: The Pathophysiology of Prerenal Azotemia, Abdominal Compartment Syndrome, and Obstructive Uropathy. Clin J Am Soc Nephrol 2022; 17: 1039–1049.
- Lee SA, Cozzi M, Bush EL, et al. Distant Organ Dysfunction in Acute Kidney Injury: A Review. Am J Kidney Dis 2018; 72: 846–856.
- Lysak N, Bihorac A, Hobson C. Mortality and cost of acute and chronic kidney disease after cardiac surgery. Curr Opin Anaesthesiol 2017; 30: 113–117.
- Matsuura R, Doi K, Hamasaki Y, et al. RRT Selection for AKI Patients With Critical Illness. Semin Nephrol 2020; 40: 498–505.
- Kuwabara S, Goggins E, Okusa MD. The Pathophysiology of Sepsis-Associated AKI. Clin J Am Soc Nephrol 2022; 17: 1050–1069.
- Achanti A, Szerlip HM. Acid-Base Disorders in the Critically Ill Patient. Clin J Am Soc Nephrol 2023; 18: 102–112.
- Chávez-Iñiguez JS, Sánchez-Villaseca SJ, García-Macías LA. [Cardiorenal syndrome: classification, pathophysiology, diagnosis and management. Literature review]. Arch Cardiol Mex 2022; 92: 253–263.
- Matsuura R, Doi K, Rabb H. Acute kidney injury and distant organ dysfunction-network system analysis. Kidney Int 2023; 103: 1041–1055.
- Inker LA, Titan S. Measurement and Estimation of GFR for Use in Clinical Practice: Core Curriculum 2021. Am J Kidney Dis 2021; 78: 736–749.
- Claure-Del Granado R, Macedo E, Chávez-Íñiguez JS. Biomarkers for Early Diagnosis of AKI: Could It Backfire? Kidney360 2022; 3: 1780–1784.
- Chávez-Íñiguez JS, Maggiani-Aguilera P, Pérez-Flores C, et al. Nephrologist Interventions to Avoid Kidney Replacement Therapy in Acute Kidney Injury. Kidney Blood Press Res 2021; 46: 629–638.
- Cheruku SR, Raphael J, Neyra JA, et al. Acute Kidney Injury after Cardiac Surgery: Prediction, Prevention, and Management. Anesthesiology 2023; 139: 880–898.
- Schwager E, Ghosh E, Eshelman L, et al. Accurate and interpretable prediction of ICU-acquired AKI. J Crit Care 2023; 75: 154278.
- von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 2008; 61: 344–9.
- Benchimol EI, Smeeth L, Guttmann A, et al. The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. PLoS Med 2015; 12: e1001885.
- Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract 2012; 120: c179–84.
- Levey AS. Defining AKD: The Spectrum of AKI, AKD, and CKD. Nephron 2022; 146: 302–305.
- Wang X, Guo Z, Chai Y, et al. Application Prospect of the SOFA Score and Related Modification Research Progress in Sepsis. J Clin Med; 12. Epub ahead of print 16 May 2023. DOI: 10.3390/jcm12103493.
- Cecconi M, Evans L, Levy M, et al. Sepsis and septic shock. Lancet 2018; 392: 75–87.
- Chen L, Rackley CR. Diagnosis and Epidemiology of Acute Respiratory Failure. Crit Care Clin 2024; 40: 221–233.
- Kurmani S, Squire I. Acute Heart Failure: Definition, Classification and Epidemiology. Curr Heart Fail Rep 2017; 14: 385–392.
- Vasques F, Cavazza A, Bernal W. Acute liver failure. Curr Opin Crit Care 2022; 28: 198–207.
- Flechet M, Guiza F, Schetz M, et al. AKIpredictor, an online prognostic calculator for acute kidney injury in adult critically ill patients: development, validation and comparison to serum neutrophil gelatinase-associated lipocalin. Intensive Care Med 2017; 43: 764–773.
- Erdfelder F, Grigutsch D, Hoeft A, et al. Dynamic prediction of the need for renal replacement therapy in intensive care unit patients using a simple and robust model. J Clin Monit Comput 2017; 31: 195–204.
- Bagshaw SM, George C, Bellomo R. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008; 12: R47.
- Bhadade R, De’Souza R, Harde MJ, et al. A Prospective Study of Acute Kidney Injury According to KDIGO Definition and its Mortality Predictors. J Assoc Physicians India 2016; 64: 22–28.
- Thakar C V, Christianson A, Freyberg R, et al. Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study. Crit Care Med 2009; 37: 2552–8.
- Ronco C, Bellomo R, Kellum J. Understanding renal functional reserve. Intensive Care Med 2017; 43: 917–920.
- Sharma A, Mucino MJ, Ronco C. Renal Functional Reserve and Renal Recovery after Acute Kidney Injury. Nephron Clin Pract 2014; 127: 94–100.
- Zhou T, Fang Y-L, Tian T-T, et al. Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies. World J Diabetes 2024; 15: 1111–1121.
- Silva PL, Chiumello D, Pozzi T, et al. Beyond the Lungs: Extrapulmonary Effects of Non-Invasive and Invasive Ventilation Strategies. J Clin Med; 14. Epub ahead of print 13 February 2025. DOI: 10.3390/jcm14041242.
- Hua Y, Ding N, Jing H, et al. Association between SOFA score and risk of acute kidney injury in patients with diabetic ketoacidosis: an analysis of the MIMIC-IV database. Front Endocrinol (Lausanne) 2024; 15: 1462330.
- Zhuang C, Hu R, Li K, et al. Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation. Front Med (Lausanne) 2024; 11: 1483710.
- Zhou Y, Liu S. Threshold heterogeneity of perioperative hemoglobin drop for acute kidney injury after noncardiac surgery: a propensity score weighting analysis. BMC Nephrol. 2022 Jun 11;23(1):206. doi: 10.1186/s12882-022-02834-3. PMID: 35690725; PMCID: PMC9188693.
- Han SS, Baek SH, Ahn SY, Chin HJ, Na KY, Chae DW, Kim S. Anemia Is a Risk Factor for Acute Kidney Injury and Long-Term Mortality in Critically Ill Patients. Tohoku J Exp Med. 2015 Dec;237(4):287–95. doi: 10.1620/tjem.237.287. PMID: 26607258.
- Chávez-Íñiguez JS, Cano-Cervantes JH, Maggiani-Aguilera P, Lavelle-Góngora N, Marcial-Meza J, Camacho-Murillo EP, Moreno-González C, Tanaka-Gutiérrez JA, Villa Zaragoza AP, Rincón-Souza KE, Muñoz-López S, Montoya-Montoya O, Navarro-Blackaller G, Sánchez-Cedillo A, Morales-Buenrostro LE, García-García G. Mortality and evolution between community and hospital-acquired COVID-AKI. PLoS One. 2021 Nov 4;16(11):e0257619. doi: 10.1371/journal.pone.0257619. PMID: 34735451; PMCID: PMC8568145.
Language: English
Page range: 176 - 185
Submitted on: Jun 14, 2025
Accepted on: Jan 18, 2026
Published on: Apr 30, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
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© 2026 Jose J. Zaragoza, Jonathan S. Chávez-Iñiguez, Armando Vazquez-Rangel, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.