Collision of vascular malignancies: Kaposi sarcoma and spindle-cell angiosarcoma in a HIV-negative patient
Abstract
Introduction
It is very uncommon for Kaposi sarcoma (KS) and angiosarcoma (AS) to occur simultaneously at the same anatomical site, especially in immunocompetent, HIV-negative people. Due to variations in prognosis and treatment, it is crucial to identify dual vascular malignancies.
Case Presentation
A 66-year-old man presented with a large exophytic tumor of the left foot at the site of previously diagnosed KS. Amputation of the second, third, and fourth toes was necessary for surgical treatment. At histopathological examination, a malignant spindle-cell vascular with strong positivity for endothelial markers was observed, with negative human herpesvirus 8 (HHV-8) staining, confirming a new vascular neoplasm, AS, in a patient with an initial KS lesion.
Conclusions
This case demonstrates that both KS and a distinct high-grade AS can develop in the same area in patients who are HIV-negative. Since multiple primary vascular tumours may coexist and substantially impact diagnosis, prognosis, and treatment.
© 2026 Denis Suciaghi, Andreea-Raluca Cozac-Szőke, Patrik-Marian Szekely, Andreea-Cătălina Tinca, Ovidiu-Simion Cotoi, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
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