Parallel, multi frequency EIT measurement, suitable for recording impedance changes during epilepsy

Dowrick, T.; Santos, G. Sato Dos; Vongerichten, A.; Holder, D.

doi:10.5617/jeb.2573

Abstract

Electrical Impedance Tomography (EIT) has been proposed as a method for imaging and localising epileptic activity in the brain. No existing EIT system meets all of the requirements for effective imaging of epilepsy. A parallel EIT system, employing frequency division multiplexing, is described, which is optimised for measuring impedance changes during epilepsy. The system is capable of imaging short duration, spontaneous events in a saline filled tank, using as little as 1ms of recorded data. In-vivo impedance measurements recorded during epilepsy in a rat model are presented.

References

Holder DS. Electrical impedance tomography: methods, history, and applications . Institute of Physics Publishing; 2005.
Search in Google Scholar Back to article
Frerichs I. Electrical impedance tomography (EIT) in applications related to lung and ventilation: a review of experimental and clinical activities. Physiol. Meas. 2000:21(2):R1-R21. http://dx.doi.org/10.1088/0967-3334/21/2/2011084718710.1088/0967-3334/21/2/201
Open DOI Search in Google Scholar Back to article
Hahn G, Just A, Dudykevych T, Frerichs I, Hinz J, Quintel M, Hellige, G. Imaging pathologic pulmonary air and fluid accumulation by functional and absolute EIT. Physiol. Meas. 2006:27(5):S187-S198 http://dx.doi.org/10.1088/0967-3334/27/5/S1610.1088/0967-3334/27/5/S16
Open DOI Search in Google Scholar Back to article
Kuen J, Woo EJ, Seo JK. Multi-frequency time-difference complex conductivity imaging of canine and human lungs using the KHU Mark1 EIT system. Physiol. Meas. 2009;30(6):S149-S164. http://dx.doi.org/10.1088/0967-3334/30/6/S1010.1088/0967-3334/30/6/S1019491441
Open DOI Search in Google Scholar Back to article
Beppu T, Ishiko T, Doi K, Matsuda T, Maeda T, Ishihara K, Ogata K, Ogawa M. A promising new treatment strategy for advanced hepatocellular carcinoma –"multi-ablation therapy" consisting of radio-frequency ablation (RFA), microwave coagulation therapy (MCT) and ethanol injection therapy (EIT). Japanese J. Cancer Chemother. 2012;65(1):23-30.
Search in Google Scholar Back to article
You F, Shuai W, Shi X, Fu F, Liu R, Dong X. In vivo monitoring by EIT for the pig's bleeding after liver injury. IFMBE Proc. 2009. p. 110–112. http://dx.doi.org/10.1007/978-3-642-03879-2_31
Search in Google Scholar Back to article
Halter RJ, Hartov A, Paulsen KD. A broadband high-frequency electrical impedance tomography system for breast imaging. IEEE Trans. Biomed. Eng. 2008:55(2):650-659. http://dx.doi.org/10.1109/TBME.2007.903516
Search in Google Scholar Back to article
Holder DS. Electrical impedance tomography (EIT) of brain function. Brain Topogr. Kluwer Academic Publishers-Human Sciences Press; 1992;5(2):87-93.
Search in Google Scholar Back to article
Bagshaw AP, Liston AD, Bayford RH, Tizzard A, Gibson AP, Tidswell AT, Sparkes M, Dehghani H, Binnie C, Holder S. Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method. Neuroimage 2003;202):752-764. http://dx.doi.org/10.1016/S1053-8119(03)00301-X1456844910.1016/S1053-8119(03)00301-X
Open DOI Search in Google Scholar Back to article
Holder D. Electrical impedance tomography in epilepsy. Electron. Eng. Miller Freeman plc; 1998;70(859):69–70.
Search in Google Scholar Back to article
Vongerichten A, Sato dos Santos G, Avery J, Walker M, Holder D. Electrical impedance tomography (EIT) of epileptic seizures in rat models – a potential new tool for diagnosis of seizures. Clin. Neurophysiol. 2014;125(supp. 1):282-283. http://dx.doi.org/10.1016/s1388-2457(14)50924-810.1016/S1388-2457(14)50924-8
Open DOI Search in Google Scholar Back to article
Meinardi H, Scott RA, Reis R, On Behalf Of The Ilae Commission on JWASS. The Treatment Gap in Epilepsy: The Current Situation and Ways Forward. Epilepsia. 2001;42(1):136-149. http://dx.doi.org/10.1046/j.1528-1157.2001.32800.x
Search in Google Scholar Back to article
Duncan JS. Selecting patients for epilepsy surgery: synthesis of data. Epilepsy Behav. 2011;20(2):230–232. http://dx.doi.org/10.1016/j.yebeh.2010.06.0402070960110.1016/j.yebeh.2010.06.040
Open DOI Search in Google Scholar Back to article
Aristovich KY, dos Santos GS, Packham BC, Holder DS. A method for reconstructing tomographic images of evoked neural activity with electrical impedance tomography using intracranial planar arrays. Physiol. Meas. 2014;35(6):2095-1109. http://dx.doi.org/10.1088/0967-3334/35/6/1095
Search in Google Scholar Back to article
Vulliemoz S, Lemieux L, Daunizeau J, Michel CM, Duncan JS. The combination of EEG source imaging and EEG-correlated functional MRI to map epileptic networks. Epilepsia. 2010;51(4):491–505. http://dx.doi.org/10.1111/j.1528-1167.2009.02342.x10.1111/j.1528-1167.2009.02342.x19817805
Open DOI Search in Google Scholar Back to article
Zhao M, Suh M, Ma H, Perry C, Geneslaw A, Schwartz TH. Focal increases in perfusion and decreases in hemoglobin oxygenation precede seizure onset in spontaneous human epilepsy. Epilepsia. 2007;48(11):2059-2067. http://dx.doi.org/10.1111/j.1528-1167.2007.01229.x1766607110.1111/j.1528-1167.2007.01229.x
Open DOI Search in Google Scholar Back to article
Suh M, Bahar S, Mehta AD, Schwartz TH. Temporal dependence in uncoupling of blood volume and oxygenation during interictal epileptiform events in rat neocortex. J. Neurosci. 2005;25(1):68-77. http://dx.doi.org/10.1523/JNEUROSCI.2823-04.200510.1523/JNEUROSCI.2823-04.200515634768
Open DOI Search in Google Scholar Back to article
Ahn S, Oh TI, Jun SC, Seo JK, Woo EJ. Validation of weighted frequency-difference EIT using a three-dimensional hemisphere model and phantom. Physiol. Meas. 2011;32(10):1663–1680. http://dx.doi.org/10.1088/0967-3334/32/10/0132190402210.1088/0967-3334/32/10/013
Open DOI Search in Google Scholar Back to article
Bahar S, Suh M, Zhao M, Schwartz TH. Intrinsic optical signal imaging of neocortical seizures: the "epileptic dip". Neuroreport. 2006;27(6):499-503. http://dx.doi.org/10.1097/01.wnr.0000209010.78599.f5
Search in Google Scholar Back to article
McCann H, Ahsan ST, Davidson JL, Robinson RL, Wright P, Pomfrett CJD. A portable instrument for high-speed brain function imaging: FEITER. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2011:7029-7032. http://dx.doi.org/10.1109/IEMBS.2011.6091777
Search in Google Scholar Back to article
Wi H, Sohal H, McEwan AL, Woo EJ, Oh TI. Multi-frequency electrical impedance tomography system with automatic self-calibration for long-term monitoring. IEEE Trans. Biomed. Circuits Syst. 2014;8(1):119-128. http://dx.doi.org/10.1109/TBCAS.2013.22567852468192510.1109/TBCAS.2013.2256785
Open DOI Search in Google Scholar Back to article
Fabrizi L, Sparkes M, Horesh L, Perez-Juste Abascal JF, McEwan A, Bayford RH, Elwes R, Binnie C, Holder D. Factors limiting the application of electrical impedance tomography for identification of regional conductivity changes using scalp electrodes during epileptic seizures in humans. Physiol. Meas. 2006:27(5):S163-S174. http://dx.doi.org/10.1088/0967-3334/27/5/S1410.1088/0967-3334/27/5/S1416636408
Open DOI Search in Google Scholar Back to article
Liston A, Bayford R, Holder D. A cable theory based biophysical model of resistance change in crab peripheral nerve and human cerebral cortex during neuronal depolarisation: implications for electrical impedance tomography of fast neural activity in the brain. Med. Biol. Eng. Comput. 2012;50(5):425-437. http://dx.doi.org/10.1007/s11517-012-0901-02248466210.1007/s11517-012-0901-0
Open DOI Search in Google Scholar Back to article
Rao, A, Gibson. A.P., Holder DS. EIT images of electrically induced epileptic activity in anaesthetised rabbits. Med. Biol. Eng. Comput. 1997;35(1):327.
Search in Google Scholar Back to article
Fabrizi L, Yerworth R, McEwan A, Gilad O, Bayford R, Holder DS. A method for removing artefacts from continuous EEG recordings during functional electrical impedance tomography for the detection of epileptic seizures. Physiol. Meas. 2010;31(8):S57-S72. http://dx.doi.org/10.1088/0967-3334/31/8/S0510.1088/0967-3334/31/8/S0520647617
Open DOI Search in Google Scholar Back to article
Granot Y, Ivorra A, Rubinsky B. Frequency-division multiplexing for electrical impedance tomography in biomedical applications. Int. J. Biomed. Imaging. 2007;2007:1-9.
Search in Google Scholar Back to article
Gracia J, Seppa VP, Viik J, Hyttinen J. Multilead measurement system for the time-domain analysis of bioimpedance magnitude. IEEE Trans. Biomed. Eng. 2012;59(8):2273-2280. http://dx.doi.org/10.1109/TBME.2012.22023182269286310.1109/TBME.2012.2202318
Open DOI Search in Google Scholar Back to article
McEwan A, Tapson J, van Schaik A, Holder DS. Code-division-multiplexed electrical impedance tomography spectroscopy. IEEE Trans. Biomed. Circuits Syst. 2009;3(5):332-338. http://dx.doi.org/10.1109/TBCAS.2009.203215910.1109/TBCAS.2009.203215923853272
Open DOI Search in Google Scholar Back to article
Tucker AS, Fox RM, Sadleir RJ. Biocompatible, high precision, wideband, improved Howland current source with lead-lag compensation. IEEE Trans. Biomed. Circuits Syst. 2013;7(1):63-70. http://dx.doi.org/10.1109/TBCAS.2012.21991142385328010.1109/TBCAS.2012.2199114
Open DOI Search in Google Scholar Back to article
Vauhkonen M, Vadâsz D, Karjalainen PA, Somersalo E, Kaipio JP. Tikhonov regularization and prior information in electrical impedance tomography. IEEE Trans. Med. Imaging . 1998;17(2):285-293. http://dx.doi.org/10.1109/42.70074010.1109/42.7007409688160
Open DOI Search in Google Scholar Back to article
Vongerichten A. Imaging Physiological and Pathological Activity in the Brain using Electric Impedance Tomography. PhD thesis, UCL, 2014.
Search in Google Scholar Back to article
Schuettler M, Ordonez JS, Henle C, Oh D, Gilad O, Holder DS. A Flexible 29 Channel Epicortical Electrode Array. IFESS 2008 - 13th Annu. Int. FES Soc. Conf. 2008.
Search in Google Scholar Back to article

Parallel, multi frequency EIT measurement, suitable for recording impedance changes during epilepsy

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