Alam J., Blackburn K., Patrick D.: Neflamapimod: Clinical phase 2b-ready oral small molecule inhibitor of p38α to reverse synaptic dysfunction in early Alzheimer’s disease. J. Prev. Alzheimers Dis., 2017; 4: 273–278
Amirrad F., Bousoik E., Shamloo K., Al-Shiyab H., Nguyen V.H., Montazeri Aliabadi H.: Alzheimer’s disease: Dawn of a new era? J. Pharm. Pharm. Sci., 2017; 20: 184–225
Arndt J.W., Qian F., Smith B.A., Quan C., Kilambi K.P., Bush M.W., Walz T., Pepinsky R.B., Bussière T., Hamann S., Cameron T.O., Weinreb P.H.: Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β. Sci. Rep., 2018; 8: 6412
Axon announces positive results from phase II ADAMANT trial for AADvac1 in Alzheimer’s disease. https://www.prnewswire.com/news-releases/axon-announces-positive-results-from-phase-ii-adamant-trial-for-aadvac1-in-alzheimers-disease-300914509.html (03.03.2020)
Bachstetter A.D., Xing B., de Almeida L., Dimayuga E.R., Watterson D.M., Van Eldik L.J.: Microglial p38α MAPK is a key regulator of pro-inflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). J. Neuroinflammation, 2011; 8: 79
Baranowska U., Wiśniewska R.J.: Receptor nikotynowy α7-nACh i jego znaczenie w funkcjonowaniu pamięci oraz wybranych chorobach ośrodkowego układu nerwowego. Postępy Hig. Med. Dośw., 2017; 71: 633–648
Cebers G., Alexander R.C., Haeberlein S.B., Han D., Goldwater R., Ereshefsky L., Olsson T., Ye N., Rosen L., Russell M., Maltby J., Eketjäll S., Kugler A.R.: AZD3293: Pharmacokinetic and pharmacodynamic effects in healthy subjects and patients with Alzheimer’s disease. J. Alzheimers Dis., 2017; 55: 1039–1053
Dominy S.S., Lynch C., Ermini F., Benedyk M., Marczyk A., Konradi A., Nguyen M., Haditsch U., Raha D., Griffin C., Holsinger L.J., Arastu-Kapur S., Kaba S., Lee A., Ryder M.I. i wsp.: Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci. Adv., 2019; 5: eaau3333
Dong Y., Li X., Cheng J., Hou L.: Drug development for Alzheimer’s disease: Microglia induced neuroinflammation as a target? Int. J. Mol. Sci., 2019; 20: 558
Egan M.F., Kost J., Voss T., Mukai Y., Aisen P.S., Cummings J.L., Tariot P.N., Vellas B., van Dyck C.H., Boada M., Zhang Y., Li W., Furtek C., Mahoney E., Harper Mozley L. i wsp.: Randomized trial of verubecestat for prodromal Alzheimer’s disease. N. Engl. J. Med., 2019; 380: 1408–1420
Femminella G.D., Frangou E., Love S.B., Busza G., Holmes C., Ritchie C., Lawrence R., McFarlane B., Tadros G., Ridha B.H., Bannister C., Walker Z., Archer H., Coulthard E., Underwood B.R. i wsp.: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: Study protocol for a randomised controlled trial (ELAD study). Trials, 2019; 20: 191
Ge M., Zhang Y., Hao Q., Zhao Y., Dong B.: Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta-analysis. Brain Behav., 2018; 8: e00982
Ghosh A.K., Cárdenas E.L., Osswald H.L.: The design, development, and evaluation of BACE1 inhibitors for the treatment of Alzheimer’s disease. W: Alzheimer’s Disease II. Topics in Medicinal Chemistry, vol 24, red.: M. Wolfe. Springer International Publishing, Cham 2016, 27–85
Hampel H., Mesulam M.M., Cuello A.C., Farlow M.R., Giacobini E., Grossberg G.T., Khachaturian A.S., Vergallo A., Cavedo E., Snyder P.J., Khachaturian Z.S.: The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain, 2018; 141: 1917–1933
Hull M., Sadowsky C., Arai H., Le Prince Leterme G., Holstein A., Booth K., Peng Y., Yoshiyama T., Suzuki H., Ketter N., Liu E., Ryan J.M.: Long-term extensions of randomized vaccination trials of ACC-001 and QS-21 in mild to moderate Alzheimer’s disease. Curr. Alzheimer Res., 2017; 14: 696–708
Jadhav S., Avila J., Schöll M., Kovacs G.G., Kövari E., Skrabana R., Evans L.D., Kontsekova E., Malawska B., de Silva R., Buee L., Zilka N.: A walk through tau therapeutic strategies. Acta Neuropathol. Commun., 2019; 7: 22
Lacosta A.M., Pascual-Lucas M., Pesini P., Casabona D., Pérez-Grijalba V., Marcos-Campos I., Sarasa L., Canudas J., Badi H., Monleón I., San-José I., Munuera J., Rodríguez-Gómez O., Abdelnour C., Lafuente A. i wsp.: Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: A randomised, double-blind, placebo-controlled, phase I trial. Alzheimers Res. Ther., 2018; 10: 12
Lee J.K., Kim N.J.: Recent advances in the inhibition of p38 MAPK as a potential strategy for the treatment of Alzheimer’s disease. Molecules, 2017; 22: 1287–1310
Lopez Lopez C., Caputo A., Liu F., Riviere M.E., Rouzade-Dominguez M.L., Thomas R.G., Langbaum J.B., Lenz R., Reiman E.M., Graf A., Tariot P.N.: The Alzheimer’s Prevention Initiative Generation Program: Evaluating CNP520 efficacy in the prevention of Alzheimer’s disease. J. Prev. Alzheimers Dis., 2017; 4: 242–246
Novak P., Schmidt R., Kontsekova E., Kovacech B., Smolek T., Katina S., Fialova L., Prcina M., Parrak V., Dal-Bianco P., Brunner M., Staffen W., Rainer M., Ondrus M., Ropele S. i wsp.: FUNDAMANT: An interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease. Alzheimers Res. Ther., 2018; 10: 108
Panza F., Lozupone M., Watling M., Imbimbo B.P.: Do BACE inhibitor failures in Alzheimer patients challenge the amyloid hypothesis of the disease? Expert Rev. Neurother., 2019; 19: 599–602
Pasinetti G.M., Wang J., Ho L., Zhao W., Dubner L.: Roles of resveratrol and other grape-derived polyphenols in Alzheimer’s disease prevention and treatment. Biochim. Biophys. Acta, 2015; 1852: 1202–1208
Petrov A.M., Lam M., Mast N., Moon J., Li Y., Maxfield E., Pikuleva I.A.: CYP46A1 Activation by efavirenz leads to behavioral improvement without significant changes in amyloid plaque load in the brain of 5XFAD mice. Neurotherapeutics, 2019; 16: 710–724
Sanabria-Castro A., Alvarado-Echeverría I., Monge-Bonilla C.: Molecular pathogenesis of Alzheimer’s disease: An update. Ann. Neurosci., 2017; 24: 46–54
Shaikh S., Rizvi S.M., Shakil S., Riyaz S., Biswas D., Jahan R.: Forxiga (dapagliflozin): Plausible role in the treatment of diabetes-associated neurological disorders. Biotechnol. Appl. Biochem., 2016; 63: 145–150
Siopi E., Llufriu-Dabén G., Cho A.H., Vidal-Lletjós S., Plotkine M., Marchand-Leroux C., Jafarian-Tehrani M.: Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuro-protection following traumatic brain injury in mice. Neuropharmacology, 2013; 67: 183–192
Smith A.: Positive results for UB-311 Alzheimer’s vaccine. http://www.pharmatimes.com/news/positive_results_for_ub-311_alzheimers_vaccine_1275579 (03.03.2020)
The New Chinese Alzheimer’s Drug (GV-971) Making its Way to Global Trials: Material Science or Marketing?. https://www.trialsitenews.com/the-new-chinese-alzheimers-drug-gv-971-making-its-way-to-global-trials-material-science-or-marketing/ (25.05.2020)
Traneurocin Phase 2A Trial Results Show Improvements for People With Mild Cognitive Impairment. https://practicalneurology.com/index.php/news/traneurocin-phase-2a-trial-results-show-improvements-for-people-with-mild-cognitive-impairment (03.03.2020)
Wang X., Sun G., Feng T., Zhang J., Huang X., Wang T., Xie Z., Chu X., Yang J., Wang H., Chang S., Gong Y., Ruan L., Zhang G., Yan S. i wsp.: Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression. Cell Res., 2019; 29: 787–803
Xicota L., Rodriguez-Morato J., Dierssen M., de la Torre R.: Potential role of (-)-epigallocatechin-3-gallate (EGCG) in the secondary prevention of Alzheimer disease. Curr. Drug Targets, 2017; 18: 174–195
Zhang C., Griciuc A., Hudry E., Wan Y., Quinti L., Ward J., Forte A.M., Shen X., Ran C., Elmaleh D.R., Tanzi R.E.: Cromolyn reduces levels of the Alzheimer’s disease-associated amyloid β-protein by promoting microglial phagocytosis. Sci. Rep., 2018; 8: 1144