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Selenium and cancer or adenoma related to the large bowel*

Open Access
|Jun 2021

Figures & Tables

Fig. 1

Search strategy
Search strategy

Fig. 2

Food sources of selenium in diet and content of selenium in different products. 1 ounce = 28.35 g; 1 cup = 150 g
Food sources of selenium in diet and content of selenium in different products. 1 ounce = 28.35 g; 1 cup = 150 g

Fig. 3

Observational studies on CRC and selenium – an overview.1all-cause mortality among patients with nonmetastatic colorectal cancer2calculated from original paper: ≥7 servings of milk/week vs <1 serving of milk/week (1 serving of milk=1 cup of milk=200 g of milk; 100 g of milk = 2 µg Se358.89 µg/day – a cut off point of total selenium4OR (95% CI) – odds ratio and 95% confidence intervalCC – colon cancer; AP – adenomatous polyps; CA – colorectal adenoma.CC – colon cancer; AP – adenomatous polyps; CA – colorectal adenoma
Observational studies on CRC and selenium – an overview.1all-cause mortality among patients with nonmetastatic colorectal cancer2calculated from original paper: ≥7 servings of milk/week vs <1 serving of milk/week (1 serving of milk=1 cup of milk=200 g of milk; 100 g of milk = 2 µg Se358.89 µg/day – a cut off point of total selenium4OR (95% CI) – odds ratio and 95% confidence intervalCC – colon cancer; AP – adenomatous polyps; CA – colorectal adenoma.CC – colon cancer; AP – adenomatous polyps; CA – colorectal adenoma

Fig. 4

Experimental studies on CRC and selenium – an overview.*advanced colorectal adenoma characteristics: size ≥10 mm, villous component, high-grade dysplasia**odds ratio as in original paper***HR with 95% CI was calculated from the original HR 1.05 99% CI (0.66–1.67)1tablets: 200 µg Se with 30 mg zinc, 2 mg vitamin A, 180 mg vitamin C, 30 mg vitamin E2200 µg yeast tablets (191–201 µg selenium content)3coctail: 4 g calcium carbonate, 101 µg selenium (from 170 µg sodium selenite), 15 mg β-carotene, 75 mg α-tocopherol, 150 mg ascorbic acid4200 µg of Se supplied in a 0.5-g high selenium baker’s yeast tablet5200 µg Se/day from L-selenomethionine6hazard ratio/risk ratio and 95% confidence interval
Experimental studies on CRC and selenium – an overview.*advanced colorectal adenoma characteristics: size ≥10 mm, villous component, high-grade dysplasia**odds ratio as in original paper***HR with 95% CI was calculated from the original HR 1.05 99% CI (0.66–1.67)1tablets: 200 µg Se with 30 mg zinc, 2 mg vitamin A, 180 mg vitamin C, 30 mg vitamin E2200 µg yeast tablets (191–201 µg selenium content)3coctail: 4 g calcium carbonate, 101 µg selenium (from 170 µg sodium selenite), 15 mg β-carotene, 75 mg α-tocopherol, 150 mg ascorbic acid4200 µg of Se supplied in a 0.5-g high selenium baker’s yeast tablet5200 µg Se/day from L-selenomethionine6hazard ratio/risk ratio and 95% confidence interval

Daily seleniuim intake through different geographic regions

Geographic differences in a daily selenium intakes (µg/day)
RegionSelenium intake (Mean ± standard error or range)
China, disease-free area13.3± 3.1
China, Keshan disease area3–11
China, seleniferous area1338
South Sweden, conventional diets40± 4
Finland, before selenium fertilization26
Finland, after selenium in fertilization56
Slovakia27± 8
Poland30–40
United Kingdom, 197460
United Kingdom, 199533
Italy41
Germany38–48
France47
India, conventional diet48
Canada98–224
United States, all80± 37
United States, seleniferous area216
Venezuela80–500

Quality of observational studies measured with a use of a Newcastle Ottawa Scale (NOS)

Observational studiesName of studyPopulationSample sizeNumber of earned stars in a Newcastle Ottawa Scale (NOS)
Lener M. et al. 2013 [20]case-controlno data available on cases recruitment; controls were selected from Polish and Estonian registers338(169 colorectal cancer patients; 169 controls)6
Connelly-Frost A. et al. 2009 [6]case-controlcases from North Carolina cancer registry; population-based control (selected from 33-county area in central North Carolina)1691(643 cases; 1048 controls)5
Fernández-Bañares F. et al. 2002 [8]case-controlhospital-based cases; controls belonging to a big survey performed in Spain were included in the study87(52 cases; 35 controls)6
Hughes D.J. et al. 2015 [14]nested case-controlcases were identified during EPIC follow-up with a use of population cancer registries (Denmark, Italy, Netherlands, Spain, United Kingdom) and other methods: health insurance records, pathology registries, active contact of study subjects; controls were matched 1:1 by a study center, but no other data were available on the control’s recruitment1932(966 cases; 966 controls)7
Peters U. et al. 2006 [27]nested case-controlcases and controls were randomly selected from 42 037 participants in the screening group of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial1525(772 cases; 777 controls)6
Wallace K. et al. 2003 [36]nested case-controlcases and controls were recruited (including special criteria) from participants of the placebo-controlled trial (those have been chosen at six clinical centers in the U.S.)552(276 cases; 276 controls)5
Takata Y. et al. 2011 [31]nested case-controlcases were recruited mostly with a use of mass mailing which were age-targeted and media announcements in areas surrounding the 40 WHI clinical centers across the U.S.; controls were selected from all eligible women in the WHI study who were alive and had not been diagnosed with CRC at the time of the case’s diagnosis;1609(804 cases; 805 controls)5
Ghadirian P. et al. 2000 [10]case-controlmainly hospital-based cases, identified through the admission offices of 5 major teaching hospitals; population-based controls (modified random-digit dialing method)1736(1048 cases, 688 controls)4
Kune G., Watson L. 2006 [18]case-controlcases from the etiological arm of population-based investigation; controls were randomly chosen from community, Melbourne, Australia1442(715 cases; 727 controls)5
Yang B. et al. 2014 [39]cohortparticipants from Cancer Prevention Study II Nutrition Cohort. II Nutrition Cohort was selected as a subgroup of larger CPS cohort in which approximately 1.2 million of people were enrolled by volunteers in all 50 states, the District of Columbia and Puerto Rico22846
Williams C.D. et al. 2010 [38]nested case-controlcases were chosen from the North Carolina Central Cancer Registry; controls <65 years were selected by using lists provided by the North Carolina Division of Motor Vehicles and the Center for Medicaid and Medicare Services for those 65 and older; controls were selected from subjects (African American or White) resided in one of 33 counties in central and eastern North Carolina. A randomized recruitment procedure was used for identifying cases and controls2076(1057 cases; 1019 controls)4
Hansen R.D. et al. 2013 [12]cohortpopulation-based cohort, which based on 54 208 members of the Diet, Cancer and Health Cohort Study54 2085

Quality of intervention studies measured with a use of a Jadad Scale

Intervention studiesNumber of points in a Jadad Scale
Bonelli L. et al. 2013 [3]3
Thompson P.A. et al. 2016 [32]2
Hofstad B. et al. 1998 [13]3
Duffield-Lillico A.J. et al. 2002 [7]5
Lippman S.M. et al. 2009 [23]4
Language: English
Page range: 426 - 436
Submitted on: May 4, 2020
Accepted on: Oct 19, 2020
Published on: Jun 16, 2021
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2021 Małgorzata Augustyniak, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.