Have a personal or library account? Click to login
The influence of monoclonal antibodies for cancer treatment on the endocrine system Cover

The influence of monoclonal antibodies for cancer treatment on the endocrine system

Open Access
|May 2021

References

  1. Agata Y., Kawasaki A., Nishimura H., Ishida Y., Tsubata T., Yagita H., Honjo T.: Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol., 1996; 8: 765–772
  2. Arima H., Iwama S., Inaba H., Ariyasu H., Makita N., Otsuki M., Kageyama K., Imagawa A., Akamizu T.: Management of immune-related adverse events in endocrine organs induced by immune checkpoint inhibitors: Clinical guidelines of the Japan Endocrine Society. Endocr. J., 2019; 66: 581–586
  3. Armand P., Chen Y.B., Redd R.A., Joyce R.M., Bsat J., Jeter E., Merryman R.W., Coleman K.C., Dahi P.B., Nieto Y., LaCasce A.S., Fisher D.C., Ng S.Y., Odejide O.O., Freedman A.S., et al.: PD-1 blockade with pembrolizumab for classical Hodgkin lymphoma after autologous stem cell transplantation. Blood, 2019; 134: 22–29
  4. Bavencio – Summary of Product Characteristics. https://www.ema.europa.eu/en//documents/product-information/bavencio-epar-product-information_en.pdf (25.09.2020)
  5. Bhasin S., Brito J.P., Cunningham G.R., Hayes F.J., Hodis H.N., Matsumoto A.M., Snyder P.J., Swerdloff R.S., Wu F.C., Yialamas M.A.: Testosterone therapy in men with hypogonadism: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab., 2018; 103: 1715–1744
  6. Bornstein S.R., Allolio B., Arlt W., Barthel A., Don-Wauchope A., Hammer G.D., Husebye E.S., Merke D.P., Murad M.H., Stratakis C.A., Torpy D.J.: Diagnosis and treatment of primary adrenal insufficiency: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab., 2016; 101: 364–389
  7. Carlé A., Pedersen I.B., Knudsen N., Perrild H., Ovesen L., Andersen S., Laurberg P.: Hypothyroid symptoms fail to predict thyroid insufficiency in old people: A population-based case-control study. Am. J. Med., 2016; 129: 1082–1092
  8. Caturegli P., Di Dalmazi G., Lombardi M., Grosso F., Larman H.B., Larman T., Taverna G., Cosottini M., Lupi I.: Hypophysitis secondary to cytotoxic T-lymphocyte-associated protein 4 blockade: Insights into pathogenesis from an autopsy series. Am. J. Pathol., 2016; 186: 3225–3235
  9. Caturegli P., Newschaffer C., Olivi A., Pomper M.G., Burger P.C., Rose N.R.: Autoimmune hypophysitis. Endocr. Rev., 2005; 26: 599–614
  10. Cha E., Klinger M., Hou Y., Cummings C., Ribas A., Faham M., Fong L.: Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients. Sci. Transl. Med., 2014; 6: 238ra70
  11. Chabner B.A., Roberts T.G. Jr.: Timeline: Chemotherapy and the war on cancer. Nat. Rev. Cancer, 2005; 5: 65–72
  12. Chalan P., Di Dalmazi G., Pani F., De Remigis A., Caturegli P.: Thyroid dysfunctions secondary to cancer immunotherapy. J. Endocrinol. Invest., 2018; 41: 625–638
  13. Chamberlain J.J., Rhinehart A.S., Shaefer C.F. Jr, Neuman A.: Diagnosis and management of diabetes: Synopsis of the 2016 American Diabetes Association standards of medical care in diabetes. Ann. Intern. Med., 2016; 164: 542–552
  14. Chang L.S., Barroso-Sousa R., Tolaney S.M., Hodi F.S, Kaiser U.B., Min L.: Endocrine toxicity of cancer immunotherapy targeting immune checkpoints. Endocr. Rev., 2019; 40: 17–65
  15. Chau C.H., Steeg P.S, Figg W.D.: Antibody-drug conjugates for cancer. Lancet, 2019; 394: 793–804
  16. Corsello S.M., Barnabei A., Marchetti P., De Vecchis L., Salvatori R., Torino F.: Endocrine side effects induced by immune checkpoint inhibitors. J. Clin. Endocrinol. Metab., 2013; 98: 1361–1375
  17. Darvin P., Toor S.M., Nair V.S., Elkord E.: Immune checkpoint inhibitors: Recent progress and potential biomarkers. Exp. Mol. Med., 2018; 50: 1–11
  18. De Filette J., Andreescu C.E., Cools F., Bravenboer B., Velkeniers B.: A systematic review and meta-analysis of endocrine-related adverse events associated with immune checkpoint inhibitors. Horm. Metab. Res., 2019; 51: 145–156
  19. Dillard T., Yedinak C.G., Alumkal J., Fleseriu M.: Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: Serious immune related adverse events across a spectrum of cancer subtypes. Pituitary, 2010; 13: 29–38
  20. Dyrka K., Miedziaszczyk M., Szałek E., Łącka K.: Drugs used in viral diseases – their mechanism of action, selected adverse effects and safety during pregnancy and lactation. Postępy Hig. Med. Dośw., 2019; 73: 491–507
  21. Emens L.A., Cruz C., Eder J.P., Braiteh F., Chung C., Tolaney S.M., Kuter I., Nanda R., Cassier P.A., Delord J.P., Gordon M.S., ElGabry E., Chang C.W., Sarkar I., Grossman W., et al.: Long-term clinical outcomes and biomarker analyses of atezolizumab therapy for patients with metastatic triple-negative breast cancer: A phase 1 study. JAMA Oncol., 2019; 5: 74–82
  22. Faje A.T., Sullivan R., Lawrence D., Tritos N.A., Fadden R., Klibanski A., Nachtigall L.: Ipilimumab-induced hypophysitis: A detailed longitudinal analysis in a large cohort of patients with metastatic melanoma. J. Clin. Endocrinol. Metab., 2014; 99: 4078–4085
  23. Fassett D.R., Couldwell W.T.: Metastases to the pituitary gland. Neurosurg. Focus., 2004; 16: E8
  24. Ferlay J., Colombet M., Soerjomataram I., Dyba T., Randi G., Bettio M., Gavin A., Visser O., Bray F.: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur. J. Cancer, 2018; 103: 356–387
  25. Ferrari S.M., Fallahi P., Galetta F., Citi E., Benvenga S., Antonelli A.: Thyroid disorders induced by checkpoint inhibitors. Rev. Endocr. Metab. Disord., 2018; 19: 325–333
  26. Freeman-Keller M., Kim Y., Cronin H., Richards A., Gibney G., Weber J.S.: Nivolumab in resected and unresectable metastatic melanoma: Characteristics of immune-related adverse events and association with outcomes. Clin. Cancer Res., 2016; 22: 886–894
  27. Gauci M.L., Laly P., Vidal-Trecan T., Baroudjian B., Gottlieb J., Madjlessi-Ezra N., Da Meda L., Madelaine-Chambrin I., Bagot M., Basset-Seguin N., Pages C., Mourah S., Boudou P., Lebbé C., Gautier J.F.: Autoimmune diabetes induced by PD-1 inhibitor-retrospective analysis and pathogenesis: A case report and literature review. Cancer Immunol. Immunother., 2017; 66: 1399–1410
  28. Gharwan H., Groninger H.: Kinase inhibitors and monoclonal antibodies in oncology: Clinical implications. Nat. Rev. Clin. Oncol., 2016; 13: 209–227
  29. Ha D., Tanaka A., Kibayashi T., Tanemura A., Sugiyama D., Wing J.B., Lim E.L., Teng K.W., Adeegbe D., Newell E.W., Katayama I., Nishikawa H., Sakaguchi S.: Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody. Proc. Natl. Acad. Sci. USA, 2019; 116: 609–618
  30. Haanen J.B., Carbonnel F., Robert C., Kerr K.M., Peters S., Larkin J., Jordan K., ESMO Guidelines Committee: Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 2017; 28: iv119–iv142
  31. Haanen J.B., Robert C.: Immune checkpoint inhibitors. Prog. Tumor Res., 2015; 42: 55–66
  32. Hafeez U., Gan H.K., Scott A.M.: Monoclonal antibodies as immunomodulatory therapy against cancer and autoimmune diseases. Curr. Opin. Pharmacol., 2018; 41: 114–121
  33. Hodi F.S., Chesney J., Pavlick A.C., Robert C., Grossman K.F., McDermott D.F., Linette G.P., Meyer N., Giguere J.K., Agarwala S.S., Shaheen M., Ernstoff M.S., Minor D.R., Salama A.K., Taylor M.H., et al.: Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial. Lancet Oncol., 2016; 17: 1558–1568
  34. Horn L., Mansfield A.S., Szczęsna A., Havel L., Krzakowski M., Hochmair M.J., Huemer F., Losonczy G., Johnson M.L., Nishio M., Reck M., Mok T., Lam S., Shames D.S., Liu J., et al.: First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer. N. Engl. J. Med., 2018; 379: 2220–2229
  35. Iglesias P.: Cancer immunotherapy-induced endocrinopathies: Clinical behavior and therapeutic approach. Eur. J. Intern. Med., 2018; 47: 6–13
  36. Illouz F., Briet C., Cloix L., Le Corre Y., Baize N., Urban T., Martin L., Rodien P.: Endocrine toxicity of immune checkpoint inhibitors: Essential crosstalk between endocrinologists and oncologists. Cancer Med., 2017; 6: 1923–1929
  37. Imfinzi – Summary of Product Characteristics. https://www.ema.europa.eu/en//documents/product-information/imfizi-epar-product-information_en.pdf (25.09.2020)
  38. Iwama S., De Remigis A., Callahan M.K., Slovin S.F., Wolchok J.D., Caturegli P.: Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci. Transl. Med., 2014; 6: 230ra45
  39. Iyer P.C., Cabanillas M.E., Waguespack S.G., Hu M.I., Thosani S.N., Lavis V.R., Busaidy N.L., Subudhi S.K., Diab A., Dadu R.: Immune-related thyroiditis with immune checkpoint inhibitors. Thyroid, 2018; 28: 1243–1251
  40. Joo W.D., Visintin I., Mor G.: Targeted cancer therapy – Are the days of systemic chemotherapy numbered? Maturitas, 2013; 76: 308–314
  41. Joshi M.N., Whitelaw B.C., Palomar M.T., Wu Y., Carroll P.V.: Immune checkpoint inhibitor-related hypophysitis and endocrine dysfunction: Clinical review. Clin. Endocrinol., 2016; 85: 331–339
  42. June C.H., Warshauer J.T., Bluestone J.A.: Is autoimmunity the Achilles’ heel of cancer immunotherapy? Nat. Med., 2017; 23: 540–547
  43. Kalogeras K.T., Nieman L.K., Friedman T.C., Doppman J.L., Cutler G.B. Jr, Chrousos G.P., Wilder R.L., Gold P.W., Yanovski J.A.: Inferior petrosal sinus sampling in healthy subjects reveals a unilateral corticotropin-releasing hormone-induced arginine vasopressin release associated with ipsilateral adrenocorticotropin secretion. J Clin Invest., 1996; 97: 2045–2050
  44. Katzke V.A., Kaaks R., Kühn T.: Lifestyle and cancer risk. Cancer J., 2015; 21: 104–110
  45. Keytruda – Summary of Product Characteristics. https://www.ema.europa.eu/en/documents/product-information/keytruda-epar-product-information_en.pdf (25.09.2020)
  46. Konda B., Nabhan F., Shah M.H.: Endocrine dysfunction following immune checkpoint inhibitor therapy. Curr. Opin. Endocrinol. Diabetes Obes., 2017; 24: 337–347
  47. Lam K.Y., Lo C.Y.: Metastatic tumours of the adrenal glands: A 30-year experience in a teaching hospital. Clin. Endocrinol., 2002; 56: 95–101
  48. Lee Y.T., Tan Y.J, Oon C.E.: Molecular targeted therapy: Treating cancer with specificity. Eur. J. Pharmacol., 2018; 834: 188–196
  49. Liu M., Guo F.: Recent updates on cancer immunotherapy. Precis Clin. Med., 2018; 1: 65–74
  50. Lupi I., Zhang J., Gutenberg A., Landek-Salgado M., Tzou S.C., Mori S., Caturegli P.: From pituitary expansion to empty sella: Disease progression in a mouse model of autoimmune hypophysitis. Endocrinology, 2011; 152: 4190–4198
  51. Manohar S., Kompotiatis P., Thongprayoon C., Cheungpasitporn W., Herrmann J., Herrmann S.M.: Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: Meta-analysis. Nephrol. Dial. Transplant., 2019; 34: 108–117
  52. Marin-Acevedo J.A., Soyano A.E., Dholaria B., Knutson K.L., Lou Y.: Cancer immunotherapy beyond immune checkpoint inhibitors. J. Hematol. Oncol., 2018; 11: 8
  53. Min L., Hodi F.S., Giobbie-Hurder A., Ott P.A., Luke J.J., Donahue H., Davis M., Carroll R.S., Kaiser U.B.: Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: A retrospective cohort study. Clin. Cancer Res., 2015; 21: 749–755
  54. Molitch M.E., Clemmons D.R., Malozowski S., Merriam G.R., Vance M.L., Endocrine Society: Evaluation and treatment of adult growth hormone deficiency: An Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab., 2011; 96: 1587–1609
  55. Ni J., Qiu L.J., Zhang M., Wen P.F., Ye X.R., Liang Y., Pan H.F., Ye D.Q.: CTLA-4 CT60 (rs3087243) polymorphism and autoimmune thyroid diseases susceptibility: A comprehensive meta-analysis. Endocr. Res., 2014; 39: 180–188
  56. Oelkers W.: Hyponatremia and inappropriate secretion of vasopressin (antidiuretic hormone) in patients with hypopituitarism. N. Engl. J. Med., 1989; 321: 492–496
  57. Opdivo – Summary of Product Characteristics. https://www.ema.europa.eu/en/documents/product-information/opdivo-epar-product-information_en.pdf (25.09.2020)
  58. Parakh S., King D., Gan H.K., Scott A.M.: Current development of monoclonal antibodies in cancer therapy. Recent Res. Cancer Res., 2020; 214: 1–70
  59. Pardoll D.M.: The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer, 2012; 12: 252–264
  60. Persani L., Ferretti E., Borgato S., Faglia G., Beck-Peccoz P.: Circulating thyrotropin bioactivity in sporadic central hypothyroidism. J. Clin. Endocrinol. Metab., 2000; 85: 3631–3635
  61. Peters C., Brown S.: Antibody-drug conjugates as novel anti-cancer chemotherapeutics. Biosci. Rep., 2015; 35: e00225
  62. Piranavan P., Li Y., Brown E., Kemp E.H., Trivedi N.: Immune checkpoint inhibitor-induced hypoparathyroidism associated with calcium-sensing receptor-activating autoantibodies. J. Clin. Endocrinol. Metab., 2019; 104: 550–556
  63. Puar T.H., Stikkelbroeck N.M., Smans L.C., Zelissen P.M., Hermus A.R.: Adrenal crisis: Still a deadly event in the 21st century. Am. J. Med., 2016; 129: 339.e1–9
  64. Raghavan R., Brady M.L., Sampson J.H.: Delivering therapy to target: Improving the odds for successful drug development. Ther. Deliv., 2016; 7: 457–481
  65. Rakoff-Nahoum S.: Why cancer and inflammation? Yale J. Biol. Med., 2006; 79: 123–130
  66. Ruggeri R.M., Campennì A., Giuffrida G., Trimboli P., Giovanella L., Trimarchi F., Cannavò S.: Endocrine and metabolic adverse effects of immune checkpoint inhibitors: An overview (what endocrinologists should know). J. Endocrinol. Invest., 2019; 42: 745–756
  67. Scott E.S., Long G.V., Guminski A., Clifton-Bligh R.J., Menzies A.M., Tsang V.H.: The spectrum, incidence, kinetics and management of endocrinopathies with immune checkpoint inhibitors for metastatic melanoma. Eur. J. Endocrinol., 2018; 178: 173–180
  68. Socinski M.A., Jotte R.M., Cappuzzo F., Orlandi F., Stroyakovskiy D., Nogami N., Rodríguez-Abreu D., Moro-Sibilot D., Thomas C.A., Barlesi F., Finley G., Kelsch C., Lee A., Coleman S., Deng Y., et al.: Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC. N. Engl. J. Med., 2018; 378: 2288–2301
  69. Song M., Giovannucci E.: Preventable incidence and mortality of carcinoma associated with lifestyle factors among white adults in the United States. JAMA Oncol., 2016; 2: 1154–1161
  70. Suzuki M., Kato C., Kato A.: Therapeutic antibodies: Their mechanisms of action and the pathological findings they induce in toxicity studies. J. Toxicol. Pathol., 2015; 28: 133–139
  71. Tecentriq – Summary of Product Characteristics. https://www.ema.europa.eu/en//documents/product-information/tecentriq-epar-product-information_en.pdf (25.09.2020)
  72. Tolcher A.W.: Antibody drug conjugates: Lessons from 20 years of clinical experience. Ann. Oncol., 2016; 27: 2168–2172
  73. Toporcov T.N., Wünsch Filho V.: Epidemiological science and cancer control. Clinics, 2018; 73: e627s
  74. Torino F., Corsello S.M., Salvatori R.: Endocrinological side-effects of immune checkpoint inhibitors. Curr. Opin. Oncol., 2016; 28: 278–287
  75. U.S. Cancer Statistics Working Group. 1999–2013 Incidence and mortality web-based report. www.cdc.gov/uscs (25.09.2020)
  76. Venetsanaki V., Boutis A., Chrisoulidou A., Papakotoulas P.: Diabetes mellitus secondary to treatment with immune checkpoint inhibitors. Curr. Oncol., 2019; 26: e111–e114
  77. Weber J.S., Postow M., Lao C.D., Schadendorf D.: Management of adverse events following treatment with anti-programmed death-1 agents. Oncologist, 2016; 21: 1230–1240
  78. Weiner L.M., Surana R., Wang S.: Monoclonal antibodies: Versatile platforms for cancer immunotherapy. Nat. Rev. Immunol., 2010; 10: 317–327
  79. Win M.A., Thein K.Z., Qdaisat A., Yeung S.C.: Acute symptomatic hypocalcemia from immune checkpoint therapy-induced hypoparathyroidism. Am. J. Emerg. Med., 2017; 35: 1039.e5–1039.e7
  80. World Health Organization. Cancer fact sheet. http://www.who.int/mediacentre//factsheets/fs297/en/ (25.09.2020)
  81. Yamazaki N., Kiyohara Y., Uhara H., Fukushima S., Uchi H., Shibagaki N., Tsutsumida A., Yoshikawa S., Okuyama R., Ito Y., Tokudome T.: Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma. Cancer Chemother. Pharmacol., 2015; 76: 997–1004
  82. Yervoy-Summary of Product Characteristics. https://www.ema.europa.eu/en/documents/product-information/yervoy-epar-product-information_en.pdf (25.09.2020)
  83. Zhao C., Tella S.H., Del Rivero J., Kommalapati A., Ebenuwa I., Gulley J., Strauss J., Brownell I.: Anti-PD-L1 treatment induced central diabetes insipidus. J. Clin. Endocrinol. Metab., 2018; 103: 365–369
Language: English
Page range: 317 - 327
Submitted on: Nov 15, 2020
Accepted on: Feb 26, 2021
Published on: May 18, 2021
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 times per year

© 2021 Kamil Dyrka, Daria Witasik, Agata Czarnywojtek, Katarzyna Łącka, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.