![[1,2,4]triazyny – potencjalne leki w chemioterapii nowotworów Cover](/_next/image?url=https%3A%2F%2Fsciendo-parsed.s3.eu-central-1.amazonaws.com%2F647088b271e4585e08a9f607%2Fcover-image.png&w=384&q=75)
Ryc. 1
![Wzory strukturalne triazyn. A-[1,2,3]triazyny, B-[1,2,4]triazyny, C-[1,3,5]triazyny]”](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_001.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=2f295dfc141f69a79e3c812465d1db509a086f4a1c6ec782e518c5523031f225&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Ryc. 2
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Ryc. 5
![Wzór strukturalny najbardziej aktywnej pochodnej 3,7-diarylo-5-(3,4,5-trimetoksyfenylo)-pirazolo[4,3-e][1,2,4]triazyny – związku 3](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_005.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=f2922f41184d270c1b281f030c2bfbff4d86142c1e6efee3079a06cd51a885d2&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
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Ryc. 7
![Wzór strukturalny pochodnych 1,5-diarylo-3-(3,4,5-trihydroksyfenylo)-1H-pirazolo[4,3-e][1,2,4]triazyny (4a-4i)](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_007.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=de5b95fff4a2bd6471283cd5ecd42fd1cec53332a8520877ba4c3888de98ab3e&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Ryc. 8
Ryc. 9
![Wzory strukturalne sulfonamidowych pochodnych pirazolo[4,3-e][1,2,4]triazyny (9a-9j)](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_009.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=e268a1ba5f68efd10612c99ba92940bb8619b1e6a48163d97801545eacfd4ba6&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
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Ryc. 12
![Wzór strukturalny związku (3-(4-(2-(dietyloamino)etoksy)fenylo)-1,6-dimetylopirymido[5,4-e]-1,2,4]triazyn-7,7(1H,6H)dion](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_012.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=cd08c64187f1bc8d23b14febf265f3ff3f3bd76c76c8bcf518f96aefc31de3f7&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
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Ryc. 15
![Wzory strukturalne pochodnych benzo[1,2,4]triazyn-7-onów](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_015.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=292da66994755f99e5960a4c42781347e0a9543b2ad6a301bea3b8e1fbfee1cf&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Ryc. 16
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Ryc. 20
![Wzory strukturalne pochodnych 6-winylo-[1,2,4]triazyn-5-onów](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_020.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=7c0d7d60e1010cf93a1306d7256b7d6de6957075871ef5e2bc4a14ec7748da7a&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Ryc. 21
![Wzory strukturalne pochodnych benzo[1,2,4]triazyn-7-onów](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_021.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=0a01b84b67979d91a710ec921b217a2704b5a0f13aade6e4687e962aca89567a&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Ryc. 22
Ryc. 23
![Wzory strukturalne nowo zsyntetyzowanych fluorowych pochodnych [1,2,4]triazynonów](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_023.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=4233339819066c3c297208b8656f42237ace2104e2b2957e8d5fc90b8b3ac263&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Ryc. 24
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Ryc. 27
![Wzory strukturalne C-nukleozydowych pochodnych zawierające układ pirolo[2,1-f][1,2,4]triazyno-4-aminowy](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_027.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=bf440a3bf0804c249bcf22b097066189e5d3d82f7ff76828971083bf48af6664&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
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Ryc. 30
![Pochodne pirydazyno[3′,4′:5,6][1,2,4]triazyno[3,4-b][1,3,4]tiadiazyny](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_030.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=ad1a030337e26315489146f7b7b140fb80aa19724ef9f3b02e740110dff2a956&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Ryc. 31
![Wzory strukturalne pochodnych układu 3-(2-arylidenehydrazynylo)-5,6-bis(4-metoksyfenylo)[1,2,4]triazyny](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7145_fig_031.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251008%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251008T015118Z&X-Amz-Expires=3600&X-Amz-Signature=15d05bca19798073902fa6863aec471f7f4bbaeb50ce3b4b130324003007e4cc&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
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Wzory strukturalne najbardziej aktywnych pochodnych
| Numer związku | Wzór związku | Podstawnik R | |
|---|---|---|---|
| 28 | a | O | |
| b | S | ||
Wzory strukturalne nowych pochodnych benzo[e][1,2,4]triazyno[2,3-c][1,2,3]triazyn-2-onów
| Wzór | Podstawniki | |||
|---|---|---|---|---|
| R1 | R2 | R3 | ||
| a | CH3 | H | H | |
| b | C6H5 | H | H | |
| c | 4-CH3-C6H4 | H | H | |
| d | 4-iPr-C6H4 | H | H | |
| e | 4-tBu-C6H4 | H | H | |
| f | 4-OCH3-C6H4 | H | H | |
| g | 4-F-C6H4 | H | H | |
| h | C6H5 | CH3 | H | |
| i | C6H5 | H | Br | |
| j | 4-F-C6H4 | H | Br | |
Nazwy grup funkcyjnych R1 i R2
| Nr związku | R1 | R2 |
|---|---|---|
| 4a | fenylowa | 2-hydroksyfenylowa |
| 4b | fenylowa | 3-hydroksyfenylowa |
| 4c | fenylowa | 4-hydroksyfenylowa |
| 4d | 4-chlorofenylowa | 2-hydroksyfenylowa |
| 4e | 4-chlorofenylowa | 3-hydroksyfenylowa |
| 4f | 4-chlorofenylowa | 4-hydroksyfenylowa |
| 4g | 4-chlorofenylowa | 4-chlorofenylowa |
| 4h | 4-chlorofenylowa | 3,4,5-trihydroksyfenylowa |
| 4i | 3,4,5-trihydroksyfenylowa | 3,4,5-trihydroksyfenylowa |
Wzory strukturalne podstawników
| PODSTAWNIK | ||||||
|---|---|---|---|---|---|---|
| a | b | c | d | e | f | |
| R= | - | - | ||||
| R1= | -H | -OH | -OCH3 | -Cl | -Br | -NO2 |
Wzór ogólny disulfonowych pochodnych układu [1,2,4]triazyny i nazwy podstawników R we wzorze 15
| Wzór ogólny | Podstawniki | |
|---|---|---|
| a: R= izopropylowa | h: R= fenylowa | |
| b: R= n-butylowa | i: R= p-toluenowa | |
| c: R= tert-butylowa | j: R= 4-metoksyfenylowa | |
| d: R= izobutylowa | k: R= 4-chlorofenylowa | |
| e: R= n-pentylowa | l: R= 4-nitrofenylowa | |
| f: R= dodecylowa | m: R= 2,4-dinitrofenylowa | |
| g: R=1-hydroksyundecylowa | n: R= 2-benzotiazolowa |
Wzory strukturalne pochodnych pirazolo[4,3-e]triazolo[4,5-b] [1,2,4]triazyny
| Podstawnik - R | ||
| a | -H | |
| b | -CH3 | |
| c | -CH2Cl | |