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Does the location of inflammatory lesions in the gastrointestinal tract determine the clinical course of Crohn’s disease?

Open Access
|Jan 2021

Figures & Tables

Fig. 1

The incidence of complications depending on the location
The incidence of complications depending on the location

Location, behaviour and disease activity in the investigated group

Parametern (%)
Gender (M/F)134 (44%)/171 (56%)
Age at diagnosis
A122 (7%)
A2194 (63%)
A389 (29%)

Lesion location:
L1 – ileal46 (15%)
L2 – colonic101 (33%)
L3 – ileocolonic158 (52%)

Disease behaviour
B1134 (44%)
B281 (27%)
B390 (29%)

Extraintestinal symptoms68 (22%)
Cigarette smoking91 (30%)
Appendectomy in the history42 (14%)

Comparison of demographic and clinical features depending on the location of inflammatory lesions

ParameterLocation L2N = 101Location L1 and L3N = 204p
Gender:p>0.05
Female56115
Male4589

Mean age46 ±16.2840 ±13.79p>0.05

Age at diagnosis:p>0.05
A1 (less than 17 years)4 (4%)18 (9%)
A2 (17–40 years)60 (59%)134 (65%)
A3 (more than 40 years)37 (37%)52 (26%)

Strictures21%79%p<0.01

Abscesses24%76%p>0.05

Fistulas33%67%p>0.05

Surgical procedures27%73%p<0.05

Extraintestinal manifestations41%59%p>0.05

Appendectomy19%81%p<0.05

Biological therapy33%67%p>0.05

Azathioprine32%68%p>0.05

Depressive disorder33%67%p>0.05

Cigarette smoking27%73%p>0.05
Language: English
Page range: 12 - 17
Submitted on: Feb 10, 2020
Accepted on: Sep 23, 2020
Published on: Jan 18, 2021
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2021 Julia Banasik, Milena Padysz, Monika Pawłowicz, Anita Gąsiorowska, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.