Genotype distributions of CYP2C9 and VKORC1 in southern Thais and their association with warfarin maintenance dose in patients with cardiac surgery

Figures & Tables

Gene symbol and variants	dbSNP rs No.	MAF in Asians*	Remarks
*CYP2C9*
CYP2C9*2 (c.430 C>T, p.Arg144Cys)	rs1799853	EAS 0.00	Variants detected in Indian-Malaysians [11]
		SAS 0.03
CYP2C9*3 (c.1075 A>C, p.Ile359Leu)	rs1057910	EAS 0.03
		SAS 0.11
*VKORC1*
–1639G>A	rs9923231	EAS 0.88
		SAS 0.15
1173C>T	rs9934438	EAS 0.88	Complete linkage disequilibrium with
		SAS 0.15	rs9923231 in a recent study from Bangkok [8]

	Number (cases)	Average warfarin dose (mg/week)	P
All	154	31	–
Sex			0.46
Male	59 (38.3%)	31.9
Female	95 (61.7%)	30.4
Age			< 0.01
<45 years	81 (52.6%)	35
≥45 years	73 (47.4%)	26.5
Body mass index			0.31
<23.4 kg/m²	90 (58.4%)	30.2
≥23.4 kg/m²	64 (41.6%)	32.2
Body surface area			0.02
<1.7 m²	103 (66.8%)	29.4
≥1.7 m²	51 (33.1%)	34.3
Uric acid food consumption			0.74
Never/seldom	144 (93.5%)	30.9
Usually	10 (6.5%)	32.3
Green vegetable food consumption		0.77
Never/seldom	57 (37.3%)	31.5
Usually	96 (62.7%)	30.9
Medication used			0.01* (List-1)
None	102 (66.2%)	32.7
List-1	50 (32.5%)	27.6
List-2	2 (1.3%)	29.8
rs9923231 (VKORC1)			<0.01**
AA	74 (48.1%)	23.8
AG	64 (41.6%)	35.3
GG	16 (10.4%)	47.3
rs1057910 (CYP2C9)			<0.01
AA (11)	144 (93.5%)	31.7
AC (13)	10 (6.5%)	20.7