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Immunotherapeutic efficacy of a Lactobacillus casei lysate as an adjuvant combined with a heated-4T1 mammary carcinoma cell lysate in a murine model of breast cancer Cover

Immunotherapeutic efficacy of a Lactobacillus casei lysate as an adjuvant combined with a heated-4T1 mammary carcinoma cell lysate in a murine model of breast cancer

Asian Biomedicine
Volume 10 (2016): Issue 4 (August 2016)
By: Ruhollah Dorostkar,  Mohammad Sadegh Hashemzadeh,  Sajjad Jafari,  Mahdi Tat,  Majdedin Ghalavand,  Mohammad Hossein Asghari and  Milad Moloudizargari  
Open Access
|Jan 2017

Figures & Tables

Figure 1

Comparison of lung weight (upper left), tumor necrosis factor (TNF)-α levels (upper right), tumor size (lower left), and tumor weight (lower right), and after immunization with a heated-4T1-cell lysate alone (hatched bar), the L. casei lysate alone (open bar), and their combination (crosshatchedbar). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P< 0.0001.
Comparison of lung weight (upper left), tumor necrosis factor (TNF)-α levels (upper right), tumor size (lower left), and tumor weight (lower right), and after immunization with a heated-4T1-cell lysate alone (hatched bar), the L. casei lysate alone (open bar), and their combination (crosshatchedbar). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P< 0.0001.

Figure 2

Levels of IL-2 (upper left), IL-12 (upper right), IL-13 (lower left), and IL-17 (lower right) after immunization with a heated-4T1-cell lysate alone (hatched bar), the L. casei lysate alone (open bar), and their combination (crosshatchedbar). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
Levels of IL-2 (upper left), IL-12 (upper right), IL-13 (lower left), and IL-17 (lower right) after immunization with a heated-4T1-cell lysate alone (hatched bar), the L. casei lysate alone (open bar), and their combination (crosshatchedbar). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
DOI: https://doi.org/10.5372/1905-7415.1004.494 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
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Language: English
Page range: 327 - 334
Published on: Jan 31, 2017
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year
Keywords:
Cancer immunotherapy,
HSP,
Lactobacillus casei,
TNF-α,
tumor,
vaccine
Related subjects:
Medicine,
Assistive professions, nursing,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other

© 2017 Ruhollah Dorostkar, Mohammad Sadegh Hashemzadeh, Sajjad Jafari, Mahdi Tat, Majdedin Ghalavand, Mohammad Hossein Asghari, Milad Moloudizargari, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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