Baseline characteristics of HIV-infected children with severe anemia
| Characteristics | Number (%) |
|---|---|
| Age (years) | |
| <1 | 19 (14.6%) |
| 1 to 5 | 66 (50.8%) |
| 6 to 10 | 32 (24.6%) |
| >10 | 13 (10.0%) |
| Median (IQR) | 3.48 (1.67 to 6.32) |
| Height-for-age z-score n = 114 | |
| > –1.5 | 9 (7.9%) |
| –1.5 to –2.5 | 24 (21.1%) |
| < –2.5 | 81 (71.0%) |
| Median (IQR) | –-3.2 (–4.2 to –2.3) |
| Weight-for-age z-score n = 126 | |
| > –1.5 | 9 (7.1%) |
| –1.5 to –2.5 | 13 (10.3%) |
| < –2.5 | 104 (82.5%) |
| Median (IQR) | –4.3 (–6.4 to –2.9) |
| CD4 cell percentage n = 116 | |
| >25 | 7 (6.0%) |
| 15 to 24 | 21 (18.1%) |
| 10 to 14 | 18 (15.5%) |
| <10 | 70 (60.4%) |
| Median (IQR) | 5.9 (1.0 to 13.9) |
| WHO category | |
| 1 or 2 | 24 (18.5%) |
| 3 | 63 (48.5%) |
| 4 | 43 (33.1%) |
| Year of ART initiation | |
| 2003 to 2005 | 40 (30.8%) |
| 2006 to 2008 | 49 (37.7%) |
| 2009 to 2013 | 41 (31.5%) |
Outcomes of children initiated on (a) AZT-containing regimens (n = 18) and (b) d4T-containing regimens (n = 111) over 36 months of follow-up
| Months of antiretroviral therapy | 0 | 6 | 12 | 18 | 24 | 30 | 36 |
|---|---|---|---|---|---|---|---|
| (a) Children on AZT, number | 18 | 9 | 8 | 7 | 6 | 6 | 6 |
| Cumulative AZT modifications | 0 | 2 | 3 | 3 | 3 | 3 | 3 |
| Deaths | 0 | 4 | 4 | 5 | 5 | 5 | 5 |
| Loss to follow-up 3.6 (95% CI 0.9–14.4) per 100 patient-years | 0 | 2 | 2 | 2 | 2 | 2 | 2 |
| Censored | 0 | 1 | 1 | 1 | 2 | 2 | 2 |
| (b) Children on d4T, number | 111 | 102 | 85 | 74 | 64 | 54 | 46 |
| Cumulative d4T modifications | 0 | 0 | 9 | 16 | 22 | 30 | 36 |
| Deaths | 0 | 7 | 10 | 12 | 13 | 13 | 13 |
| Loss to follow-up 2.6 (95% CI 1.5–4.4) per 100 patient-years | 0 | 1 | 3 | 3 | 4 | 5 | 6 |
| Censored | 0 | 1 | 1 | 6 | 8 | 9 | 10 |