Figure 1
Figure 2
Endothelial biomarkers and flow mediated dilatation (FMD) between exercise treadmill test (ETT) results
| Endothelial biomarkers | ETT (–) N = 30 | ETT (+) N = 30 | P |
|---|---|---|---|
| Lp-PLA2 (IU/ml) | 296.64 (223.59-365.43) | 173,86 (124.92-305.07) | 0.009 |
| Oxidized LDL (ng/ml) | 66.22 (62.55-93.48) | 63.88 (57.90-102.31) | NS |
| hs-CRP (mg/L) | 1.54 (0.86-3.06) | 1.11 (0.56-2.26) | 0.07 |
| Nitric oxide (µM) | 55.67 + 13.43 | 46.76 + 13.53 | 0.06 |
| Sialic acid (mg/ml) | 43.15 + 10.92 | 45.04 + 10.35 | NS |
| FMD1 (%) | 48.48 (32.21-65.78) | 35.27 (16. 99-62.54) | NS |
| FMD2 (%) | 56.37 + 39.54 | 51.41 + 33.18 | NS |
Clinical characteristics of patients between exercise treadmill test (ETT) results
| Clinical Characteristics | ETT (–) N = 30 | ETT (+) N = 30 | P |
|---|---|---|---|
| Age (years) | 48 ± 7 | 56 ± 7 | <0.05 |
| Men/women (number) | 17/13 | 20/10 | 0.057 |
| BMI (kg/m2) | 27.8 ± 3.6 | 26.2 ± 2.8 | NS |
| Systolic blood pressure (mmHg) | 130 ±20 | 140 ± 10 | 0.08 |
| Diastolic blood pressure (mmHg) | 80 ± 10 | 80 ± 10 | NS |
| Diabetic (%) | 10 | 16.7 | NS |
| Triglyceride (mg/dL) | 154 ± 77 | 141 ± 64 | NS |
| Total cholesterol (mg/dL) | 215 ± 46 | 191 ± 28 | 0.017 |
| LDL cholesterol (mg/dL) | 140 ± 37 | 136 ± 30 | NS |
| HDL cholesterol (mg/dL) | 53 ± 17 | 46 ± 8 | 0.07 |
| Glucose (mg/dL) | 102 ± 32 | 102 ± 14 | NS |
| Blocked vessel (%) | 0% | 23, 3% | 0.005 |
Patient characteristics and endothelial biomarkers across FMD tertiles
| 1st tertile (<16%) | 2nd tertile (16%-54%) | 3rd tertile(>54%) | P | |
|---|---|---|---|---|
| Age | 51 ± 8 | 52 ± 9 | 53 ± 8 | NS |
| BMI | 28.4 ± 3.9 | 26.3 ± 2.8 | 26.5 ± 3.3 | NS |
| Smoking (%) | 20% (2) | 40% (4) | 40% (4) | NS |
| Family history (%) | 44% (4) | 33% (3) | 22% (2) | NS |
| Systolic BP (mmHg) | 134 ± 17 | 130 ± 14 | 131 ± 12 | NS |
| Diastolic BP (mmHg) | 80 ± 6 | 80 ± 5 | 80 ± 8 | NS |
| Triglyceride (mg/dl) | 149 (101-237) | 123 (82-165) | 127 (89-199) | NS |
| Total cholesterol (mg/dl) | 214 ± 45 | 191 ± 32 | 203 ± 39 | NS |
| LDL cholesterol (mg/dl) | 144 ± 36 | 130 ± 28 | 141 ± 36 | NS |
| HDL cholesterol (mg/dl) | 51 ± 18 | 47 ± 10 | 50 ± 12 | NS |
| Glucose (mg/dl) | 96 (87-104) | 103 (91-109) | 94 (87-117) | NS |
| Lp-PLA2 (IU/ml) | 274.9 (193.9-365.8) | 269.6 (147.3-369.6) | 254.8 (141.1-310.7) | NS |
| Oxidized LDL (ng/ml) | 66.9 (63.2-82.4) | 63.9 (60.5-69.1) | 64.9 (59.9-168.7) | NS |
| hs-CRP (mg/L) | 1.4 (0.8-4.7) | 1.3 (0.7-2.2) | 1.5 (0.4-2.4) | NS |
| Nitric oxide (µM) | 53 ± 12 | 47 ± 14 | 54 ± 15 | NS |
| Sialic acid (mg/ml) | 43.5 ± 10.7 | 43.2 ± 10.9 | 45.6 ± 10.5 | NS |