Have a personal or library account? Click to login
Mini review article. Human herpesvirus-6 and the etiology of multiple sclerosis: a literature review Cover

Mini review article. Human herpesvirus-6 and the etiology of multiple sclerosis: a literature review

Open Access
|Feb 2017

References

  1. 1. Enbom M, Wang F-Z, Fredrikson S, Martin C, Dahl H, Linde A. Similar humoral and cellular immunological reactivities to human herpesvirus 6 in patients with multiple sclerosis and controls. Clin Diagn Lab Immunol. 1999; 6:545-910.1128/CDLI.6.4.545-549.1999
  2. 2. Mancuso R, Delbue S, Borghi E, Pagani E, Calvo MG, Caputo D, et al. Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis. J Med Virol. 2007; 79:192-910.1002/jmv.20777
  3. 3. Challoner PB, Smith KT, Parker JD, Macleod DL, Coulter SN, Rose TN, et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci USA. 1995; 92:7440-4.10.1073/pnas.92.16.7440
  4. 4. Enbom M. Human herpesvirus 6 in the pathogenesis of multiple sclerosis. APMIS. 2001; 109:401-11.10.1034/j.1600-0463.2001.090601.x
  5. 5. Stinissen P, Raus J, Zhang J. Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies. Crit Rev Immunol. 1997; 17:33-75.10.1615/CritRevImmunol.v17.i1.20
  6. 6. Hunter SF, Hafler DA. Ubiquitous pathogens. Links between infection and autoimmunity in MS? Neurology. 2000; 55:164-5.10.1212/WNL.55.2.164
  7. 7. Brown KA. Factors modifying the migration of lymphocytes across the blood-brain barrier. Int Immunopharmacol. 2001; 1:2043-62.10.1016/S1567-5769(01)00129-1
  8. 8. Bruck W. Clinical implications of neuropathological findings in multiple sclerosis. J Neurol. 2005; 252:III/ 10-4.10.1007/s00415-005-2011-516170494
  9. 9. Harbige LS, Sharief MK. Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis. Br J Nutr. 2007; 98:S46-53.10.1017/S000711450783301017922959
  10. 10. Gompels UA, Nicholas J, Lawrence G, Jones M, Thomson BJ, Martin MED, et al. The DNA sequence of human herpes virus-6 structure, coding content and genome evolution. Virology. 1995; 209:29-51.10.1006/viro.1995.12287747482
  11. 11. Sanders VJ, Felisan S, Waddell A, Tourtellotte WW. Detection of herpesviridae in post-mortem multiple sclerosis brain tissue and controls by polymerase chain reaction. J Neurovirol. 1996; 2:249-58.10.3109/13550289609146888
  12. 12. Taus C, Pucci E, Cartechini E, Fie A, Guiliani G, Clementi M, et al. Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis. Acta Neurol Scand. 2000; 101:224-8.10.1034/j.1600-0404.2000.101004224.x
  13. 13. Opsahl ML, Kennedy PGE. Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter. Brain. 2005; 128:516-27.10.1093/brain/awh390
  14. 14. Matute C, Alberdi E, Domercq M, Perez-Cerda F, Perez-Samart☐n A, Sanchez-Gomez MV. The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci. 2001; 24: 224-30.10.1016/S0166-2236(00)01746-X
  15. 15. Miller G. The dark side of glia. Science. 2005; 308: 778-81.10.1126/science.308.5723.77815879185
  16. 16. Farooqui AA, Horrocks LA, Farooqui T. Modulation of inflammation in brain: a matter of fat. J Neurochem. 2007; 101:577-99.10.1111/j.1471-4159.2006.04371.x17257165
  17. 17. Clark DA. Human herpesvirus 6 and multiple sclerosis. Herpes. 1999; 6:73-7.
  18. 18. Gopfert E, Pytlik S, Debuch H. 2′,3′-Cyclic nucleotide 3′-phosphohydrolase and lipids of myelin from multiple sclerosis and normal brains. J Neurochem. 1980; 34: 732-9.10.1111/j.1471-4159.1980.tb11205.x6243698
  19. 19. Martin C, Enbom M, Soderstrom M, Fredrikson S, Dahl H, Lycke J, et al. Absence of seven human herpesviruses, Including HHV-6, by polymerase chain reaction in CSF and blood from patients with multiple sclerosis and optic neuritis. Acta Neurol Scand. 1997; 95:280-3. 10.1111/j.1600-0404.1997.tb00210.x9188902
  20. 20. Franciotta D, Bestetti A, Sala S, Perucca P, Jarius S, Price RW, et al. Broad screening for human herpesviridae DNA in multiple sclerosis cerebrospinal fluid and serum. Acta Neurol Belg. 2009; 109:277-82.
  21. 21. Alvarez-Lafuente R, Garcia-Montojo M, De Las Heras V, Dominguez-Mozo MI, Bartolome M, Benito- Martin MS, et al. Herpesviruses and human endogenous retroviral sequences in the cerebrospinal fluid of multiple sclerosis patients. Mult Scler. 2008; 14:595-601.10.1177/135245850708642518566025
  22. 22. Mancuso R, Hernis A, Cavarretta R, Caputo D, Calabrese E, Nemni R, et al. Detection of viral DNA sequences in the cerebrospinal fluid of patients with Multiple Sclerosis. J Med Virol. 2009; 82:1051-7.10.1002/jmv.2176420419821
  23. 23. Sotelo J, Ordonez G, Pineda B, Flores J. The participation of varicella zoster virus in relapses of multiple sclerosis. Clin Neurol Neurosurg. 2014; 119: 44-8.10.1016/j.clineuro.2013.12.02024635924
  24. 24. van Nierop GP, Hintzen RQ, Verjans GMGM. Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands. J. Neurovirol. 2014; DOI 10.1007/s13365-014-0248-4.10.1007/s13365-014-0248-424671719
  25. 25. Mechelli R, Vittori D, Coarelli G, Aimati L, De Luca O, Romano S, et al. Screening for neurotropic viruses in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. MSJ. 2014; 20:638.10.1177/135245851350123323959710
  26. 26. Ahram M, El-Omar A, Baho Y, Lubad MA. Association between human herpesvirus 6 and occurrence of multiple sclerosis among Jordanian patients. Acta Neurol Scand. 2009; 120:430-5.10.1111/j.1600-0404.2009.01187.x19519805
  27. 27. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: Results of an international survey. Neurology. 1996; 46:907-11.10.1212/WNL.46.4.9078780061
  28. 28. Reipert B. Multiple sclerosis: a short review of the disease and its differences between men and women. J Men’s Health Gen. 2004; 1:334-40.10.1016/j.jmhg.2004.10.005
  29. 29. Secchiero P, Zella D, Crowley RW, Gallo RC, Lusso P. Quantitative PCR for human herpesviruses 6 and 7. J Clin Microbiol. 1995; 33:2124-30.10.1128/jcm.33.8.2124-2130.19952283477559960
  30. 30. Chapenko S, Millers A, Nora Z, Logina I, Kukaine R, Murovska M. Correlation between HHV-6 reactivation and multiple sclerosis disease activity. J Med Virol. 2003; 69:111-7.10.1002/jmv.1025812436486
  31. 31. Alvarez-Lafuente R, Martin-Estefania C, de Las Heras V, Castrillo C, Picazo JJ, Varela de Seijas E, et al. Active human herpesvirus 6 infection in patients with multiple sclerosis. Arch Neurol. 2002; 59:929-33.10.1001/archneur.59.6.92912056928
  32. 32. Behzad-Behbahani A, Hadi Mikaeili M, Entezam M, Mojiri A, Pour GY, Arasteh MM, et al. Human herpesvirus-6 viral load and antibody titer in serum samples of patients with multiple sclerosis. J Microbiol Immunol Infect. 2011; 44:247-51.10.1016/j.jmii.2010.08.00221524958
  33. 33. Ohyashiki JH, Takaku T, Ojima T, Abe K, Yamamoto K, Zhang Y, et al. Transcriptional profiling of human herpesvirus type B (HHV-6B) in an adult T cell leukemia cell line as an in vitro model for persistent infection. Biochem Biophys Res Commun. 2005; 329:11-7.10.1016/j.bbrc.2005.01.090
  34. 34. Adams CWM. Pathology of multiple sclerosis: progression of the lesion. Br Med Bull. 1977; 33:15-20.10.1093/oxfordjournals.bmb.a071388
  35. 35. Hay KA, Tenser RB. Leukotropic herpesviruses in multiple sclerosis. Mult Scler. 2000; 6:66-8.10.1177/135245850000600202
  36. 36. Sotelo J, Ordonez G, Pineda B. Varicella-zoster virus at relapses of multiple sclerosis. J Neurol. 2007; 254: 493-500.10.1007/s00415-006-0402-x
  37. 37. Hon GM, Erasmus RT, Matsha T. Low prevalence of human herpesvirus-6 and varicella zoster virus in blood of multiple sclerosis patients, irrespective of inflammatory status or disease progression. J Clin Neurosci. 2014; doi: 10.1016/j.jocn.2013.10.027. [Epub ahead of print]
  38. 38. Fredj NB, Rotola A, Nefzi F, Chebel S, Rizzo R, Caselli E, et al. Identification of human herpesviruses 1 to 8 in Tunisian multiple sclerosis patients and healthy blood donors. J Neurovirol. 2006; 18:12-9.10.1007/s13365-011-0056-z
  39. 39. Mameli G, Astone V, Arru G, Marconi S, Lovato L, Serra C, et al. Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not human herpesvirus 6. J Gen Virol. 2007; 88:264-74.10.1099/vir.0.81890-0
  40. 40. Alvarez-Lafuente R, Martin-Estefania C, de las Heras V, Castrillo C, Cour I, Picazo JJ, et al. Prevalence of herpesvirus DNA in MS patients and healthy blood donors. Acta Neurol Scand. 2002; 105:95-9.10.1034/j.1600-0404.2002.1o050.x
  41. 41. Ablashi DV, Eastman HB, Owen CB, Roman MM, Friedman J, Zabriskie JB, et al. Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients. J Clin Virol. 2000; 16: 179-91.10.1016/S1386-6532(99)00079-7
  42. 42. Ben-Fredj N, Ben-Selma W, Rotola A, Nefzi F, Benedetti S, Frih-Ayed M, et al. Prevalence of human herpesvirus U94/REP antibodies and DNA in Tunisian multiple sclerosis patients. J Neurovirol. 2013; 19:42-7.10.1007/s13365-012-0138-623179681
  43. 43. Alvarez-Lafuente R, de las Heras V, Bartolome M, Picazo JJ, Arroyo R. Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection. Arch Neurol. 2004; 61:1523-7.10.1001/archneur.61.10.1523
  44. 44. Schippling S, Heesen C, Zander A, Martin R. Stem cell transplantation in multiple sclerosis. J Neurol. 2008; 255:43-7.10.1007/s00415-008-6008-8
  45. 45. Compston A, Coles A. Multiple sclerosis. Lancet. 2002; 359:1221-31.10.1016/S0140-6736(02)08220-X
  46. 46. Chatzimanolis N, Kraus J, Bauer R, Engelhardt B, Bregenzer T, Kuehne BS, et al. CD45RA + ICAM-3 + lymphocytes in interferon-β1b-treated and -untreated patients with relapsing-remitting multiple sclerosis. Acta Neurol Scand. 2004; 110:377-85.10.1111/j.1600-0404.2004.00346.x15527450
  47. 47. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS), Neurology. 1983; 33:1444-52.10.1212/WNL.33.11.14446685237
  48. 48. Gustafsson R, Reitsma R, Stralfors A, Lindholm A, Press R, Fogdell-Hahn A. Incidence of human herpesvirus 6 in clinical samples from Swedish patients with demyelinating diseases. J Microbiol Immunol Infect. 2013; doi: 10.1016/j.jmii.2013.03.009. [Epub ahead of print]
DOI: https://doi.org/10.5372/1905-7415.0803.294 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
Language: English
Page range: 303 - 313
Published on: Feb 4, 2017
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year

© 2017 Gloudina M. Hon, Rajiv T. Erasmus, Tandi E. Matsha, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.